Malignant Melanoma in Children

Ruiz-Maldonado, Ramon

doi:10.1001/archderm.1997.03890390103014

Cited by 54 publications

(16 citation statements)

References 108 publications

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“…[1][2][3][4] Although melanoma in children remains rare, accounting for only approximately 1-3% of all malignancies in children, 5 incidence increases markedly from the teenage years and in Australia, melanoma is now the most common cancer in those between 15-44 years of age. 6 Most studies of melanoma in adolescents have been descriptive case series [7][8][9][10] and little is known of the causes of melanoma in this age group.…”

mentioning

confidence: 99%

Melanoma in adolescents: A case‐control study of risk factors in Queensland, Australia

Youl

Aitken

Hayward

et al. 2001

Intl Journal of Cancer

111

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The incidence of melanoma increases markedly in the second decade of life but almost nothing is known of the causes of melanoma in this age group. We report on the first population-based case-control study of risk factors for melanoma in adolescents ( Only 2 of 147 cases tested had germline variants or mutations in CDKN2A. There was no association with sunscreen use overall, however, never/rare use of sunscreen at home under the age of 5 years was associated with increased risk (OR ‫؍‬ 2.2, 95%CI ‫؍‬ 0.7-7.1). There was no difference between cases and controls in cumulative sun exposure in this high-exposure environment. Factors indicating genetic susceptibility to melanoma, in particular, the propensity to develop nevi and freckles, red hair, blue eyes, inability to tan and a family history of the disease are the primary determinants of melanoma among adolescents in this high solar radiation environment. Lack of association with reported sun exposure is consistent with the high genetic susceptibility in this group.

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mentioning

confidence: 99%

Melanoma in adolescents: A case‐control study of risk factors in Queensland, Australia

Youl

Aitken

Hayward

et al. 2001

Intl Journal of Cancer

111

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“…Perhaps the most fundamental problem in the treatment of pediatric melanoma is the ambiguity of the diagnosis [1,3,7,10]. Many dermatological entities resemble melanoma in the pediatric population.…”

Section: Discussionmentioning

confidence: 99%

“…However, its utilization in pediatric melanoma is seldom reported and even more rare in the region of head and neck [3,6]. With a recent increase in the incidence of adolescent melanoma [7,8], the need for an widely accepted therapeutic protocol has also increased. We hope the cases presented here will add to our over-all experience with pediatric melanoma of the head and neck and aid physicians in the future work-up of pediatric melanoma.…”

Section: Introductionmentioning

confidence: 99%

Auricular malignant melanoma of early childhood: the role of sentinel node biopsy

O-Lee

Rowe

2004

International Journal of Pediatric Otorhinolaryngology

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“…O nevo de Spitz é um nevo juncional dérmico ou composto que ocorre freqüentemente em crianças como tumor solitário, pequeno, indolor, róseo, localizado em geral na face, e também pode ter o mesmo comportamento. O nevo azul é uma lesão dérmica de cor uniforme, que varia entre o azul escuro e o negro, de poucos milímetros, bem delimitada, redonda ou oval, plana ou satélite, solitária ou não, comum na face e no dorso da mão, e sua degeneração maligna é excepcional 2,5 .…”

Section: Introductionunclassified

“…Assim, alguns autores recomendam a remoção profilática dos grandes nevos melanocíticos precocemente para eliminar um potencial precursor do melanoma, ressaltando o bom resultado estético e até possíveis benefícios psicológicos 2,4,6 .…”

Section: Introductionunclassified