Malignant melanoma arising in a cystic teratoma of the ovary

O'Leary, A. J.; Tejura, H.

doi:10.1080/01443610500243984

Cited by 9 publications

(7 citation statements)

References 11 publications

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“…6 To date, only 46 cases have been reported in the literature, of which one report is a compilation of 20 cases. [1][2][3][4][8][9][10][11][12] Differentiation of primary from metastatic melanoma in the ovary is challenging for pathologists. 13 This differentiation is mostly based on the criteria proposed by Cronje and Woodruff, 14 which is provided in Box 1.…”

Section: Discussionmentioning

confidence: 99%

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Hulikal

BanothManilal

GangasaniRevanth

et al. 2015

Journal of Gynecologic Surgery

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Background: Primary melanoma of the ovary is very rare; fewer than 50 cases have been reported to date. The diagnosis is challenging and is usually one of exclusion of the more-common metastatic diseases. This article describes such a case in detail and reviews relevant literature. Case: A 58-year-old perimenopausal woman presented with a 2-month history of pain and distension of the abdomen. On evaluation, she was found to have bilateral ovarian complex cysts with ascites. In view of her elevated CA 125 level and positive ascitic fluid cytology, she underwent a staging laparotomy. The final histopathology was reported as a malignant melanoma of the left ovary within a cystic teratoma with metastatic involvement of the right ovary, peritoneum, omentum, and mesentery. Results: Following surgery, this patient was evaluated with a whole body F18 flourodeoxyglucose positron emission tomography/computed tomography scan to look for any probable site of primary or other metastatic areas that had not revealed any other sites of disease. She was referred to the medical oncology services of the Sri Venkateswara Institute of Medical Sciences, in Tirupathi, Chittoor District, AP, India, for further treatment. As of this writing, she had completed two cycles of temozolomide chemotherapy with few side-effects. Conclusions: Primary malignant melanoma of the ovary is difficult to diagnose without a component of teratoma. Even with teratomatous elements, this is a diagnosis that involves excluding more-common metastatic disease from a more-common cutaneous primary. ( J GYNECOL SURG 31:166)

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Section: Discussionmentioning

confidence: 99%

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Hulikal

BanothManilal

GangasaniRevanth

et al. 2015

Journal of Gynecologic Surgery

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“…A comprehensive literature review revealed 37 cases of malignant melanoma originating from ovary. The first case dates back to 1901 (6)(7)(8)(9)(10)(11)(12). Cronge and Wooduff accepted absence of an extra-ovarian focus of malignant melanoma, presence of a focus of malignant melanoma in the same ovary harboring teratoma, and showing melanocyte junctional activity as diagnostic criteria for a primary ovarian malignant melanoma (17).…”

Section: Discussionmentioning

confidence: 99%

“…Primary ovarian malignant melanoma was first reported in 1901 (5). A total of 37 cases have been reported so far in the english literature (6)(7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Synchronous primary endometrial carcinoma and metastatic malignant melanoma in an ovarian cystic teratoma

Genç¹,

Sivrikoz²,

Genç³

et al. 2014

TJPATH

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ABSTRACTmalignant transformation of a benign cystic teratoma of the ovary is only rarely seen. A review of the english literature revealed no reports of a malignant melanoma developing from concurrent primary endometrial carcinoma and ovarian cystic teratoma. We report herein a 54-year-old nulliparous woman who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for a pelvic mass and was diagnosed by histopathological examination to have a malignant melanoma developing from concurrent primary endometrial carcinoma and ovarian cystic teratoma. No foci of primary malignant melanoma except for the ovary were found upon clinical examination. The patient received postoperative interferon alpha 2B and radiotherapy. She was still asymptomatic at 12 months of follow-up.Key Words: melanoma, Ovary, Teratoma, endometrial neoplasms ÖZOverin benign kistik teratomunun malign transformasyonu oldukça nadirdir. İngiliz literatürünün gözden geçirilmesinde eş zamanlı primer endometrial karsinom ve overde kistik teratomda gelişen malign melanom olgusuna rastlanmamıştır. Burada 54 yaşında doğum yapmamış, total abdominal histerektomi ve bilateral salpingo ooferektomi sonrasında primer endometrial karsinom ve ovaryan kistik teratomda gelişen malign melanom tanısı alan bir olgu sunuyoruz. Klinik muayenede over dışında melanom saptanmadı. Hasta operasyon sonrası interferon-alpha (IFN-α) 2B ve radyoterapi tedavisi aldı. Tedavi sonrası 12 ay boyunca izlenen hasta asemptomatiktir.

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“…[1] Only 31 cases have been reported, including a compilation of 20 cases [1] and individual case reports. [2][3][4][5][6][7][8][9][10][11] A 50-year-old woman, P 3+0+3+3, presented with pain and distension of the lower abdomen for one month. Her present and previous menstrual cycles were normal and there was no other symptom.…”

Section: Primary Malignant Melanoma In Cystic Teratoma Of Ovarymentioning

confidence: 99%

“…[8] The literature consisting of case reports and case series reveals the aggressive behavior of the tumor with 50% survival, at the end of two years. [1][2][3][4][5][6][7][8][9][10][11][12] The pattern of the spread is similar to an epithelial ovarian tumor and the prognosis is worse than the squamous cell cancer in a dermoid cyst. [5] The present case was stage IA ovarian cancer and received postoperative chemotherapy, considering the poor prognosis of the tumor.…”

Section: Primary Malignant Melanoma In Cystic Teratoma Of Ovarymentioning

confidence: 99%

Primary malignant melanoma in cystic teratoma of ovary

et al. 2009

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Sir,The study by Somdatta et al. is an eye opener. [1] Even as the west is trying to detect breast cancer as early as possible using self examination of breast, we in India are still tackling a gross lack of awareness about even the existence of disease. Even more distressing is the prevalent belief regarding breast feeding being responsible for breast cancer. Studies have documented an even greater lack of awareness as also the lack of screening for cervical carcinoma in India. [2] Situation is no different for other cancers including tobacco related tumours.Even as India continues to battle infectious diseases, focus should not be lost of the cancer related morbidity and mortality. The problems vis-a-vis India are multifold-an acute lack of awareness amongst community, self-neglect and late presentation, prevalence of alternative systems and quacks, prevalent tobacco use, poverty and resource crunch. This calls for a complete overhaul of the national cancer control programme with strong emphasis on primary prevention of major cancers in the country. There is a dire need to educate the general public about the common presentations and the need for early treatment. This can be through involvement of mass media including television, radio and the print media. Other health programmes like the Reproductive and child health programme etc can be utilised as opportunities to educate the public about presentation and early detection of cancers. As has been mentioned, community based educational interventions can increase community awareness about cancer and can yield a positive change in practice of strategy for early detection of cancer. [3] Tobacco related legislation should be implemented in letter and spirit as tobacco is singularly responsible for more than half of cancer related mortality. The youth of the nation, including the school children should be educated about cancers and the causative factors like tobacco. As far as prevention of cancer related mortality is concerned, awareness is life.

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Malignant melanoma arising in a cystic teratoma of the ovary

Cited by 9 publications

References 11 publications

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Metastasizing Primary Malignant Melanoma of the Ovary: A Diagnostic Enigma

Synchronous primary endometrial carcinoma and metastatic malignant melanoma in an ovarian cystic teratoma

Primary malignant melanoma in cystic teratoma of ovary

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