Malignant Melanoma Appearing in Seborrheic Keratosis

Yakar, Jona Ben; Sagi, Amiram; Mahler, Dan; Zirkin, Howard J.

doi:10.1111/j.1524-4725.1984.tb00481.x

Cited by 27 publications

(17 citation statements)

References 8 publications

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“…There are several reports of this association, but most authors believe that it is a coincidence rather than an example of malignant transformation. [4][5][6] In contrast, some reports identify a series of malignant neoplasms associated with seborrheic keratoses. The presence of a concurrent neoplasm, including melanoma, with a seborrheic keratosis raises the possibility of a pathogenic relationship in lesional development.…”

Section: Discussionmentioning

confidence: 81%

Seborrheic keratosis with basal clear cells: A distinctive microscopic mimic of melanoma in situ

Neuhaus¹,

LeBoit

McCalmont

2006

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 81%

Seborrheic keratosis with basal clear cells: A distinctive microscopic mimic of melanoma in situ

Neuhaus¹,

LeBoit

McCalmont

2006

Journal of the American Academy of Dermatology

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“…The most frequent neoplasms associated with SK are basal cell carcinoma, squamous cell carcinoma and melanoma [4, 5, 6, 7, 8, 9]. The predominant histologic subtype of basal cell carcinoma found to be associated with SK is the superficial type in which foci of malignant neoplastic germinative cells emanate from the basal layer of the epidermis.…”

Section: Discussionmentioning

confidence: 99%

Seborrheic Keratosis with Compound Nevus, Junctional Nevus and Basal Cell Carcinoma in the Same Lesion

et al. 2001

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Seborrheic keratosis can be associated with different neoplasms such as basal cell carcinomas, squamous cell carcinomas and melanomas. We describe an unusual case of a man who presented with a brown plaque on his back. The clinical diagnosis was melanoma. Histopathologic examination of the lesion revealed four neoplasms: a compound nevus, a junctional nevus, a superficial basal cell carcinoma and a seborrheic keratosis. Although this association most likely represents a chance phenomenon, we discuss the possibility that the seborrheic keratosis developed from the nevus, and that subsequently the junctional nevus and the basal cell carcinoma developed from the seborrheic keratosis.

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“…In addition to melanocytic nevi, malignant neoplasms arising within or adjacent to seborrheic keratoses have been previously documented [1,2,4–7]. Cascajo et al performed a retrospective analysis of 54 malignant neoplasms in conjunction with seborrheic keratoses, most of them corresponding to basal cell carcinomas, followed in number by squamous cell carcinomas and two malignant melanomas [1].…”

Section: Answer and Explanationmentioning

confidence: 99%

“…Cascajo et al performed a retrospective analysis of 54 malignant neoplasms in conjunction with seborrheic keratoses, most of them corresponding to basal cell carcinomas, followed in number by squamous cell carcinomas and two malignant melanomas [1]. In addition to the cases reported by Cascajo et al, a handful of cases of melanoma arising in seborrheic keratoses have been reported in the literature [2,4–7]. This association is believed to be more than a simple coincidental collision between tumors, and the term compound tumor is proposed as the most appropriate appellation [1,2].…”

Section: Answer and Explanationmentioning

confidence: 99%