Malignant interstitial cell testicular tumor

Mahon, Frank B.; Gosset, F; Trinity, R. G.; Madsen, Paul O.

doi:10.1002/1097-0142(197305)31:5<1208::aid-cncr2820310525>3.0.co;2-6

Cited by 36 publications

(10 citation statements)

References 8 publications

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“…[29,30] We made significant efforts to rule out metastasis and other possible causes of hyperprolactinemia. Therefore, in the absence of any identifiable factors that could explain the maintenance of high levels of Prolactin we suspected it was secondary to the persistent effect of hyperoestrogenaemia and hypogonadism coexisting in patients with LCT postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Leydig cell tumor of the testis presenting with gynaecomastia due to hyperprolactinemia after orchiectomy

Rivera

Rwegerera

Chowdhury

et al. 2017

CRIM

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Leydig cell tumors (LCT) are rare and represent 1% to 3% of all tumors of the testis. LCTs can either be benign or malignant with clinical presentation varying from testicular mass associated with endocrinal manifestations to metastatic lesions in case of malignant tumors. We describe a 25-year-old man who presented with an isolated painless mass of the left testes which was confirmed by ultrasonography. An orchiectomy was subsequently performed and the histopathological analysis revealed a leydig cell tumor. Three months after surgery, the patient presented with bilateral gynaecomastia; estradiol, testosterone and gonadotropin levels as well as tumor markers (carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP) and human chorionic gonadotropin (β-HCG) were within normal ranges but prolactin was high in two different measurements. No evidence of tumor recurrence or metastases was found and different underlying causes of hyperprolactinemia including use of drugs, pituitary adenoma, hypothyroidism and renal failure were ruled out. After 6 month of treatment with Cabergoline the prolactin level and breast size were remarkably reduced. Patients with benign LCT have a favourable prognosis but in order to rule out tumor recurrence or a persistent effect of their hormonal disorder, follow-up should include regular hormonal and imaging studies.

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Section: Discussionmentioning

confidence: 99%

Leydig cell tumor of the testis presenting with gynaecomastia due to hyperprolactinemia after orchiectomy

Rivera

Rwegerera

Chowdhury

et al. 2017

CRIM

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“…It must be stressed that Leydig cell tumours of the testis are extremely rare, accounting for 2% of testicular tumours. Unlike the majority of testicular tumours, they have occurred in patients aged between 2 and 90 years (mean 60) (Mahon et al, 1973). In the pre-pubertal group they may present with precocious puberty, macrogenitosomia and hirsutism.…”

Section: Discussionmentioning

confidence: 99%

Gynaecomastia and Occult Leydig Cell Tumour of the Testis

Mellor

McCUTCHAN²

1989

British Journal of Urology

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Two patients with Leydig cell tumours of the testis are described. Both presented with gynaecomastia, but on initial examination had apparently normal testes. The causative tumour did not become obvious for some months, despite being carefully sought. Review of the literature suggests that gynaecomastia preceding a readily palpable tumour is a recognised problem. The detection and management of Leydig cell tumours of the testis are discussed.

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“…Interstitial cell tumours of the testis are usually benign (Mahon et al, 1973). However malignancy does occur and the metastases were observed in 9"; of all adult patients over the age of 60 (Mahon et al, 1973). Malignancy has not been described in children (Gittes et al, 1970).…”

Section: Discussionmentioning

confidence: 99%