Leydig Cell Tumour of the Testis With Gynaecomastia and Elevated Oestrogen, Progesterone and Prolactin Levels: Case Report

Pérez, Concepción Barroso; Novoa, José Miguel López; Alcañiz, J; Salto, L; Barceló, B

doi:10.1111/j.1365-2265.1980.tb03404.x

Cited by 14 publications

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Characterization of a feminizing testicular leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture

Czernobilsky

Schneider

et al. 1985

Cancer

View full text Add to dashboard Cite

A patient with gynecomastia and a nonpalpable testicular Leydig cell tumor is presented. Estradiol and progesterone levels were elevated whereas serum testosterone was reduced. Following removal of the tumor the hormonal values returned to normal with reduction of gynecomastia. Tumor tissue was maintained in culture for 9 days during which high estradiol levels as well as lesser quantities of testosterone and progesterone were demonstrated in the culture medium. Elevation of progesterone supports a block of 17 alpha-hydroxylase activity caused by increased endogenous estradiol. This is the first case of a cultured feminizing testicular Leydig cell tumor in which hormone production was demonstrated. The freshly removed tumor as well as the cultured tissue material were studied by immunocytochemical methods and biochemical analysis of cytoskeletal proteins. These methods revealed vimentin as the exclusive type intermediate sized filament in both. This is the first demonstration of vimentin in a Leydig cell tumor, in agreement with its occurrence in normal Leydig cells.

show abstract

Characterization of a feminizing testicular leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture

Czernobilsky

Schneider

et al. 1985

Cancer

View full text Add to dashboard Cite

show abstract

Ectopic prolactin secretion from a gonadoblastoma

Hoffman

Gala

Kovács

et al. 1987

Cancer

View full text Add to dashboard Cite

A 6.5-year-old girl developed isosexual, pseudoprecocious puberty secondary to a gonadoblastoma. The tumor was found to produce and secrete both immunoassayable and boiassayable prolactin based on immunohistochemical techniques and the presence of a prolactin gradient between the tumor vein and peripheral vein. The source of the prolactin was a Sertoli-like cell. Neither growth hormone nor growth hormone-releasing hormone was detected within the tumor. This case confirms the ectopic production of prolactin by neoplastic tissue.

show abstract

The Testis

Federman¹

1985

Contemporary Endocrinology

View full text Add to dashboard Cite

Leydig Cell Tumour of the Testis With Gynaecomastia and Elevated Oestrogen, Progesterone and Prolactin Levels: Case Report

Cited by 14 publications

References 12 publications

Characterization of a feminizing testicular leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture

Characterization of a feminizing testicular leydig cell tumor by hormonal profile, immunocytochemistry, and tissue culture

Ectopic prolactin secretion from a gonadoblastoma

The Testis

Contact Info

Product

Resources

About