Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Murase, Takuhei; Nakamura, Shigeo; Tashiro, Kazuhiro; Suchi, Taizan; Hiraga, Junji; Hayasaki, Naoyuki; Kimura, Masayuki; Murakami, Masamoto; Mizoguchi, Yoshikazu; Suzuki, Takashi; Saito, Hidehiko

doi:10.1046/j.1365-2141.1997.4623265.x

Cited by 102 publications

(96 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Splenectomy samples from two patients with AIVL had cut surfaces that were beef red in color and there was a diffuse, large, B-cell lymphoma cell infiltrate in the red pulp [14]. However, the international consensus meeting of intravascular large B-cell lymphoma (IVLBCL) proposed a new definition of IVLBCL, which included cases from both western and Asian countries [39].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

et al. 2008

View full text Add to dashboard Cite

We evaluated six cases of diffuse large B-cell lymphoma (DLBCL) involving the red pulp of the spleen. All had B symptoms and an aggressive clinical course. The lymphoma cells proliferated diffusely and non-cohesively in the cords of the red pulp. The lymphoma involved the bone marrow in four of the five patients and the liver in all four of the patients examined. However, lymph node (LN) involvement was rare at presentation, and systemic LN involvement was not observed even in the terminal phase. The lymphoma cells infiltrated the intrasinusoidal/intravascular and interstitial spaces of the involved tissues and were detected in the peripheral blood in two of the six patients. CD5-expressing lymphoma cells were detected in four of the five patients examined. Because these cases had some unique clinical features and occurred in distinct splenic sites, we proposed that primary splenic DLBCL manifesting in red pulp is a distinct clinicopathological entity.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Based on these features, we propose that DLBCLRP is a distinct clinicopathologic entity. Moreover, we discuss the relationship between DLBCLRP and an Asian variant of intravascular lymphomatosis (IVL) with splenomegaly [14].…”

Section: Introductionmentioning

confidence: 99%

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

et al. 2008

View full text Add to dashboard Cite

show abstract

“…[12][13][14] These include a purportedly distinct variant of intrasinusoidal splenic LBCL occurring primarily in Asians which is associated with histocytic proliferation, prominent hemophagocytosis, and aggressive behavior. [15][16][17] The nature of these latter cases remains unclear and it has been speculated that some may represent a variant of intravascular LBCL.…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases

2005

View full text Add to dashboard Cite

Two unusual cases of large B-cell lymphoma with predominant splenic and bone marrow (BM) involvement and similar clinical and histopathologic features are described. Both patients presented with nonspecific constitutional symptoms, unexplained cytopenias, and splenomegaly. Splenectomy revealed diffuse red pulp involvement by large B-cell lymphoma. The perisplenic lymph nodes were also involved diffusely with effacement of normal nodal architecture, excluding a diagnosis of intravascular large B-cell lymphoma. BM biopsies revealed striking erythroid hyperplasia without overt morphologic evidence of involvement by lymphoma. Immunoperoxidase staining of the marrow biopsies with antibodies to CD20 and erythroidassociated antigens revealed involvement by large B-cell lymphoma morphologically resembling the early pronormoblasts. In both cases there was prominent, but not exclusive, intravascular/intrasinusoidal lymphomatous marrow infiltration. These cases represent an unusual variant of large B-cell lymphoma with distinctive patterns of splenic and BM involvement. Furthermore, they underscore the difficulties in identifying intrasinusoidal marrow infiltration by lymphoma in H&E-stained biopsy slides and demonstrate that this pattern of marrow infiltration may be seen in cases of large B-cell lymphoma distinct from the intravascular variant. Keywords: diffuse large B-cell lymphoma; intravascular lymphoma; spleen; bone marrow; erythroid hyperplasia; non-Hodgkin lymphoma Diffuse large B-cell lymphoma (LBCL) can involve nodal or extranodal sites; however, initial presentation in the spleen occurs infrequently. 1 Typically when diffuse LBCL involves the spleen it forms discrete tumoral masses within the splenic parenchyma. 2 A recent report detailed other less common patterns of splenic involvement by LBCL including diffuse infiltration of the splenic red pulp. 3 The clinicopathologic features of diffuse LBCL with these unusual patterns of splenic involvement have yet to be fully elucidated. Described herein are the distinctive clinical and histopathologic features of two cases of splenic LBCL with diffuse red pulp infiltration and concurrent involvement of lymph nodes and bone marrow (BM). These cases had strikingly similar clinical presentations chiefly characterized by dyspnea, unexplained cytopenias, and splenomegaly. In both instances, splenectomy performed to alleviate the cytopenias revealed diffuse, homogeneous involvement of the splenic red pulp by diffuse LBCL. Although the pattern of splenic red pulp involvement and the clinical features raised the possibility of intravascular LBCL, in both cases there was parenchymal involvement of splenic hilar lymph nodes, excluding this diagnosis as defined by the most recent WHO criteria. 4 Furthermore, both cases had prominent BM involvement by lymphoma, which was difficult to detect by routine morphologic evaluation of hematoxylin and eosin (H&E)-stained biopsy slides. This difficulty was due both to the presence of prominent erythroid hyperplasia as well as a predominan...

show abstract

“…A new variant of IVL, termed the Asian Variant of IVL (AIVL), is proposed by the authors. This variant is characterized by hemophagocytic syndrome (HPS), usually associated with bone marrow and hepatosplenic invasion, but rarely with neurological abnormalities and skin lesions (3). This distinct subgroup of IVL seems to be prevalent in eastern Asia and maymerit separate consideration because of the problems posed in initial diagnosis and subsequent therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

Asian Variant of CD5+ Intravascular Large B-cell Lymphoma with Splenic Infarction.

Tokura¹,

Murase²,

Toriyama³

et al. 2003

Intern. Med.

Self Cite

View full text Add to dashboard Cite

A 57-year-old man was admitted with fever and epigastralgia, and presented with splenomegaly and pancytopenia. A CTscan revealed splenic infarctions. There were no lymphadenopathies, skin lesions, or neurological abnormalities. A splenectomy was performed. Bone marrow involvement with hemophagocytosis was noted. The diagnosis of Asian variant of intravascular diffuse large B-cell lymphomawas based on intravascular and sinusoidal distribution of large CD5+B cells. The patient died of the disease ll months after onset. To our knowledge, this is the first report of AIVL that presented with splenic infarction. This distinct lymphoma should be included in the differential diagnosis of splenic infarction. (Internal Medicine 42: 105-109, 2003)

show abstract

Malignant histiocytosis‐like B‐cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature

Cited by 102 publications

References 21 publications

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

Primary splenic diffuse large B-cell lymphoma manifesting in red pulp

Diffuse large B-cell lymphoma with distinctive patterns of splenic and bone marrow involvement: clinicopathologic features of two cases

Asian Variant of CD5+ Intravascular Large B-cell Lymphoma with Splenic Infarction.

Contact Info

Product

Resources

About