Asian Variant of CD5+ Intravascular Large B-cell Lymphoma with Splenic Infarction.

Abstract

A 57-year-old man was admitted with fever and epigastralgia, and presented with splenomegaly and pancytopenia. A CTscan revealed splenic infarctions. There were no lymphadenopathies, skin lesions, or neurological abnormalities. A splenectomy was performed. Bone marrow involvement with hemophagocytosis was noted. The diagnosis of Asian variant of intravascular diffuse large B-cell lymphomawas based on intravascular and sinusoidal distribution of large CD5+B cells. The patient died of the disease ll months after onset. To our knowledge, this is the first report of AIVL that presented with splenic infarction. This distinct lymphoma should be included in the differential diagnosis of splenic infarction. (Internal Medicine 42: 105-109, 2003)

Intravascular large B cell lymphoma: proposed of the strategy for early diagnosis and treatment of patients with rapid deteriorating condition

“…(2) Most of patients are elderly and have poor PS, which make it difficult to administer sufficient chemotherapy. (3) Majority of IVL cases are CD5-positive [13,27] and non-GCB type [27], which are known to be associated with poor prognosis [39,45,46].…”

Divergence and heterogeneity of neoplastic PD‐L1 expression: Two autopsy case reports of intravascular large B‐cell lymphoma

“…The clinicopathologic findings and prognoses of our patients have been already documented in details as separate case reports and are briefly summarized in Table .…”

“…Cases #1 and 2 exhibited typical histopathologic features of IVLBCL with CD5 and CD10 positivity on their tumor cells, respectively …”

“…We initially surveyed 10 autopsy cases with IVLBCL (male: female = 5:5, a median onset age of 61 years [51–99 years]) by immunostaining the FFPE sections with three anti‐PD‐L1 antibodies (SP142, 1:50, Spring Bioscience, Fremont, CA, USA; E1J2J, 1:50, Cell Signaling Technology, Danvers, MA, USA; and 28‐8, 1:50, Abcam, Cambridge, UK), but only two previously reported cases presented with successful antigen retrieval . The eight remaining cases showed no positivity in the neoplastic cells or cells in the tumor microenvironment probably due to the prolonged formalin fixation.…”

Intravascular large B-cell lymphoma: Remission after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisolone chemotherapy

“…7 The Asian variant of IVL is characterized by hemophagocytosis, fever, anemia, thrombocytopenia, respiratory disturbances, disseminated intravascular coagulation, hepatosplenomegaly, and, in particular, bone-marrow involvement without lymphadenopathy. 10,21 The clinical course and good therapeutic response in our case suggests that our patient had the cutaneous form of IVL. However, the nature of the pulmonary involvement remains uncertain, as the patient refused further evaluation.…”