Malignant granular cell tumor of the esophagus

The aim of the study was to consider the qualifications necessary for the procedure, the surgical treatment, and the long-term results. Material and methods. During the period between 1990 and 2005, twenty-five patients with benign esophageal tumors underwent treatment. Clinical symptoms, the size and localization of the tumor, and histological type were considered in cases of patients qualified for surgical intervention. Not all patients with esophageal leiomyomas were subjected to preoperative verification. Intraoperative endoscopic examinations identified the pathology, especially in cases of small lesions. Results. Patients diagnosed with esophageal leiomyomas were subjected to tumor enucleation. In cases of Abrikosow's tumor (three patients), the tumor was removed with the esophageal wall. Four patients underwent endoscopic resection. Esophageal fistulas during the perioperative period were not observed. Mortality was not observed during patient hospitalization. None of the cases presented recurrence or malignant transformation. Conclusions. Surgical treatment is the method of choice for treating benign esophageal tumors. During the postoperative period, neither disease recurrence nor malignant transformation was observed.

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“…The tumor rarely accompanies esophageal carcinoma (24,25). This tumor is most often localized to the lower third of the esophagus (26).…”

Section: Discussionmentioning

confidence: 99%

Benign Esophageal Tumors

Włodarczyk¹,

Olechnowicz²,

Kocoń³

2008

Polish Journal of Surgery

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“…1,2 Granular cell tumors typically present as subdermal or submucosal masses of unclear cellular origin in the skin, breast, or tongue. [7][8][9][10] Only about 1% to 9% of all granular cell tumors affect the gastrointestinal tract, and only 2% of those are found in the esophagus. [7][8][9][10] Most esophageal lesions (90%) are solitary and tend to arise in the distal esophagus.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10] Only about 1% to 9% of all granular cell tumors affect the gastrointestinal tract, and only 2% of those are found in the esophagus. [7][8][9][10] Most esophageal lesions (90%) are solitary and tend to arise in the distal esophagus. 8 Granular cell tumors arise most commonly during the fourth to sixth decades of life and are most common in women and in blacks.…”

Section: Discussionmentioning

confidence: 99%

“…Tissue diagnosis is confirmed by immunohistochemical expression of S-100 protein. 7,9,10 Malignant transformation of granular cell tumors is quite rare (ie, 2% to 4%) with only 4 cases reported. [8][9][10] Endoscopically assisted enucleation is currently the preferred management strategy, although some investigators have recommended conservative management of asymptomatic lesions with serial imaging, with surgical resection reserved for large lesions (> 1 cm) or those that are symptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…7,9,10 Malignant transformation of granular cell tumors is quite rare (ie, 2% to 4%) with only 4 cases reported. [8][9][10] Endoscopically assisted enucleation is currently the preferred management strategy, although some investigators have recommended conservative management of asymptomatic lesions with serial imaging, with surgical resection reserved for large lesions (> 1 cm) or those that are symptomatic. 8 In both cases reported herein, the tumors were symptomatic and were large enough and involved enough of the surrounding tissue to necessitate surgical intervention and segmental or partial resection of the cervical esophagus.…”

Section: Discussionmentioning

confidence: 99%

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Isolated cervical esophageal reconstruction for rare esophageal tumors

Marin¹,

Yu²,

Weber³

2006

Head & Neck

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Background. Isolated defects in the cervical esophagus in patients who have not undergone total laryngectomy are uncommon. We report 2 cases of rare esophageal tumors requiring reconstruction of the cervical esophagus after tumor resection.Methods and Results. The patients were a 51-year-old woman with an esophageal granular cell tumor and a 54-yearold woman with an esophageal schwannoma. Both defects were reconstructed with a radial forearm flap. A small subclinical leak developed in 1 patient and healed spontaneously within 2 weeks. At 1 year and 2 years of follow-up, both patients were consuming a normal diet and had normal voices.Conclusions. A thin and well-vascularized flap such as the radial forearm flap is essential for reconstructing an isolated cervical esophageal defect so as to maximize functional outcome. Keywords: cervical esophagus; esophageal reconstruction; granular cell tumor of the esophagus; schwannoma of the esophagus; radial forearm flap Schwannomas and granular cell tumors rarely arise in the esophagus. They usually do not cause clinical symptoms that prompt medical intervention. In many cases, such tumors can be enucleated without the need for esophageal resection. There have been no reports in the literature of reconstruction of the cervical esophagus with free tissue transfers after resection of esophageal schwannomas or granular cell tumors. Reconstruction of the esophagus in patients with an intact larynx and trachea is technically more difficult because of limited exposure. We present 2 cases of rare, symptomatic cervical esophageal tumors that required free flap reconstruction to restore esophageal integrity.CASE REPORTS Case 1. The patient was a 51-year-old woman who initially presented with a history of dysphagia that had lasted several months. Further workup revealed a hyperfunctioning thyroid nodule that was removed in a right thyroid lobectomy. The procedure was uncomplicated, and pathologic examination revealed a benign thyroid adenoma. The patient recovered well postoperatively but returned 1 year later with progressively worsening dysphagia Correspondence to: P. Yu

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Endoscopic mucosal biopsy – histopathological interpretation

Montgomery¹,

Kalloo²

2015

Yamada' S Textbook of Gastroenterology

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Malignant granular cell tumor of the esophagus

Cited by 40 publications

References 7 publications

Benign Esophageal Tumors

Benign Esophageal Tumors

Isolated cervical esophageal reconstruction for rare esophageal tumors

Endoscopic mucosal biopsy – histopathological interpretation

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