Malignant Glomus tumour of the head and neck–A review

Jayaraj, Gifrina; Sherlin, Herald J; Ramani, Pratibha; K.R, Don; Santhanam, Archana; Gheena, S; Ramasubramanian, Abilasha

doi:10.1016/j.ajoms.2018.12.009

Cited by 5 publications

(4 citation statements)

References 25 publications

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“…The glomus tumor is a benign vascular neoplasm arising from the glomus body, a mesenchymal derived neuromyoarterial structure found within the reticular dermis of the skin 1,2 . It serves to control blood pressure and temperature by regulating blood flow in the vessels supplying the skin 1 .…”

Section: Introductionmentioning

confidence: 99%

“…The glomus tumor is a benign vascular neoplasm arising from the glomus body, a mesenchymal derived neuromyoarterial structure found within the reticular dermis of the skin. 1,2 It serves to control blood pressure and temperature by regulating blood flow in the vessels supplying the skin. 1 The glomus tumor was first described within the literature as a distinct clinical entity in 1812 by Wood, with the histopathological description established in 1924 by Masson.…”

Section: Introductionmentioning

confidence: 99%

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A case of cutaneous malignant glomus tumor

Senff,

Orschulok,

Lambie

et al. 2023

J Cutan Pathol

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Glomus tumors are well‐known but relatively rare vascular neoplasms, with their malignant counterparts still being rarer. There are very few reports of cutaneous malignant glomus tumors, and the current limited evidence suggests that they follow a more indolent course than deep‐seated malignant glomus tumors. Herein, we are reporting a case of cutaneous malignant glomus tumor. A 94‐year‐old male presented with a right‐sided ulcerated scalp lesion, which, on biopsy, showed a diffusely infiltrative epithelioid malignancy with considerable pleomorphism and a notable perivascular growth pattern. The tumor cells were positive for smooth muscle actin (SMA) and h‐caldesmon, and negative for cytokeratin MNF116, CK5, p40, S100, SOX10, HMB45, Melan‐A, ERG, CD31, CD45, CD3, CD20, ALK, desmin, CD68, CD34, and HHV8. A diagnosis of cutaneous malignant glomus tumor was made, and the patient underwent a wider excision. Cutaneous malignant glomus tumors are extremely rare and should be considered when examining unusual cutaneous mesenchymal tumors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A case of cutaneous malignant glomus tumor

Senff,

Orschulok,

Lambie

et al. 2023

J Cutan Pathol

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“…The rarer malignant variant accounts for <1% of all soft-tissue tumors [ 2 ]. They are described to have predominant low-grade malignancy, but reports of aggressive glomangiosarcoma behavior thus leading to fatal metastases in up to 38% of cases are reported in the literature [ 3 ]. We present a case of a female patient with a palpable large and painful mass in the abdominal wall.…”

Section: Introductionmentioning

confidence: 99%

Low-grade malignancy glomus tumor of the abdominal wall: a case report and literature review

Trajkovski,

Trajkovska,

Kostadinova-Kunovska

et al. 2023

Journal of Surgical Case Reports

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Glomus tumors are painful neoplasms arising from the glomus body (responsible for body temperature and blood pressure regulation) in the skin. Although mostly present in the interdigital areas, glomus tumors can arise elsewhere. The vast majority of them are benign. Rarely, malignant variants are reported and are associated with the potential for local infiltration and metastatic dissemination. The abdominal wall location of glomus tumors is extremely rare regardless of whether they present as benign or malignant. We present a case of a 58-year-old female patient with a low-grade malignancy infiltrative glomus tumor of the abdominal wall.

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“…A similar principle applies to Van Gieson staining technique [5]. Our extensive slide collection has enabled us to publish numerous articles in the past 3 years [6][7][8][9][10][11][12][13]. Based on these inspirations, we have planned to compare and evaluate muscle involvement and degeneration in advanced oral submucous fibrosis using three different stains namely, H&E, Van Gieson, and Masson's Trichrome to employ them for better histological grading of the disease.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of muscle involvement & degeneration in advanced oral submucous fibrosis using three different stains – a retrospective cross-sectional study

Umashankar

Sherlin

Jayaraj

et al. 2021

BDS

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Background: Oral submucous fibrosis (OSMF) is graded according to various histological factors which include the epithelial changes and the connective tissue changes. These features could be identified in routine Hematoxylin and Eosin (H and E) staining in shades of pink. However, the use of special stains provides a contrast to various connective tissue components thereby aiding in better visualization of these connective tissue changes in advanced OSMF cases. Objective: To compare and evaluate muscle involvement and degeneration in advanced oral submucous fibrosis using three different stains namely, H&E, Van Gieson, and Masson’s Trichrome. Material and Methods: 10 Formalin-fixed paraffin-embedded tissue sections of advanced OSMFwere stained using 3 different stains namely Hematoxylin and Eosin (H&E), Van-Gieson, and Masson trichrome. The results obtained were tabulated and statistically analyzed using Kruskal Wallis ANOVA. Results: The hyalinization and fibrosis involving the skeletal muscle were better visualized in Masson’s Trichrome but were not statistically significant. The muscle degeneration in deeper areas was better visualized in Masson’s trichrome when compared to the H&E and Van Gieson. Conclusion: Hematoxylin and eosin stains all the connective tissue components in various shades of pink, use of special stains bestows contrast between different components of connective tissue, thus improvising grading of OSMF. Masson’s trichrome stain can be used as a single adjunct to hematoxylin and eosin stain as changes in the superficial and deeper connective tissue could be ascertained. Keywords Fibrosis; Masson’s trichrome stain; Muscle degeneration; Oral submucous fibrosis grading.

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Malignant Glomus tumour of the head and neck–A review

Cited by 5 publications

References 25 publications

A case of cutaneous malignant glomus tumor

A case of cutaneous malignant glomus tumor

Low-grade malignancy glomus tumor of the abdominal wall: a case report and literature review

Evaluation of muscle involvement & degeneration in advanced oral submucous fibrosis using three different stains – a retrospective cross-sectional study

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