Malignant Glioma Developed on a Patient Under Deep Brain Stimulation: Pitfalls in Management

The Role of Safe MRI in Diagnosing an Unusual Case of High‐Grade Glioma Adjacent to Globus Pallidus Interna DBS Electrode

“…However, the rare incidence of brain neoplasms in chronic DBS patients makes an association difficult to ascertain, and further observational studies as dystonia DBS patients continue to age is needed. Hence, although the few reports of tumors spatially associated with DBS electrodes have been mostly high‐grade gliomas, association between the two remains unknown 7,8 . This case serves as one of the few documented observations to date.…”

“…Hence, although the few reports of tumors spatially associated with DBS electrodes have been mostly high-grade gliomas, association between the two remains unknown. 7,8 This case serves as one of the few documented observations to date. In summary, this case provides an important experience for other centers in safely using MRI in DBS patients without complications, and demonstrates a rare presentation of high-grade glioma in a chronic DBS patient.…”

“…This is one of the few reported cases of high-grade glioma spatially associated with a DBS electrode. 7 One case of piloastrocytoma 7 and two cases of high-grade glioma 7,8 have been reported immediately adjacent to DBS leads. Since most patients with DBS for Parkinson's disease pass away within two decades of implantation, genetic dystonia patients with DBS from young age have longer stimulation exposure, which raises the possibility of an increased risk of adverse effects to chronic stimulation.…”

LncRNA MIR4435‐2HG functions as a ceRNA against miR‐125a‐5p and promotes neuroglioma development by upregulating TAZ

“…This study used GraphPad Prism 7.0 (GraphPad Software, Inc., San Diego, CA, USA) for statistical analysis. 30 F I G U R E 2 MIR4435-2HG was positively correlated with TAZ, and miR-125a-5p was negatively correlated with TAZ. (A,B) We used luciferase reporter assays to analyze the interactions between MIR4435-2HG and miR-125a-5p, miR-125a-5p, and TAZ.…”

“…This study used GraphPad Prism 7.0 (GraphPad Software, Inc., San Diego, CA, USA) for statistical analysis. 30 …”