The Role of Safe MRI in Diagnosing an Unusual Case of High‐Grade Glioma Adjacent to Globus Pallidus Interna DBS Electrode

Glioblastoma, IDH‐Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization, and Review of the Literature

“…We read with interest the work by Balachandar et al 1 regarding the presentation of a high-grade glioma in the setting of deep brain stimulator (DBS) placement. Several reports of primary brain tumors of astrocytic lineage after chronic deep brain stimulation (DBS) have been published in recent years, raising concern for a causal relationship (Table S1).…”

Reply to: Glioblastoma, IDH‐Wildtype, CNS WHO Grade 4, Associated with Deep Brain Stimulation in a Patient with Essential Tremor: Report of a Case with Molecular Characterization and Review of the Literature

“…In our case, we highlight HGG in longer‐term exposure of more than 20‐years of DBS in a DYT‐1 dystonia patient implanted at a younger age. 4 Furthermore, the tumor centered in the cerebral peduncle, which is an uncommon location for spontaneous HGG. Although any associations remain theoretical, DBS is known to increase the expression of trophic factors and drive neurogenesis.…”