Malignant fibrous histiocytoma of the larynx

Abstract

Malignant fibrous histiocytomas of the upper respiratory tract are rare, aggressive, mesenchymal neoplasms. There have been sporadic cases reported in the English language literature. This paper reports the case of a subglottic malignant fibrous histiocytoma in a 26-year-old female. A review of the important clinical-pathological features of this type of tumor is presented. The treatment of choice appears to be wide surgical resection of the tumor. Although the published experience is small, it appears that tumors of the subglottic space are characterized by a younger patient population and a better prognosis than those of the larynx.

Pleomorphic Sarcoma of Larynx

“…The clinical symptoms for laryngeal PS are dyspnea, hoarseness, stridor, dysphagia, hemoptysis, and diagnosis established after removal, 10,11 as in our case. On indirect laryngosocpy, one can find pedunculated or polypoidal mass, whereas ulceration is common finding for laryngeal carcinoma similar to our case.…”

Fibrous histiocytoma of the larynx

“…The site of presentation in males tends to be on the vocal folds while subglottis is the most common site in females. Of the four benign tumours reported so far in the literature, three were in females (Godoy et al, 1986). More rarely the patient can present with dyspnoea and dysphagia depending upon the site and size of the lesion.…”

“…Kaufman and Stout first used the term fibrous histiocytoma in 1961. Prior to this it was known by various names such as fibrous xanthoma, atypical fibrous histiocytoma, reticulohistiocytoma and giant cell tumours (Godoy et al, 1986). Blitzer et al (1977) in their review of all head and neck malignant fibrous histiocytomas reported as many as 21 different names for this lesion before a consensus was reached in 1969.…”

Benign fibrous histiocytoma of the larynx: presentation of a case and review of the literature

“…19 Volmer (1985) 38 20 Godoy et al (1986) 1975). Other authors state that the histiocyte originates from an undifferentiated mesenchymal stem cell (Ferlito, 1978;Ferlito et al, 1979).…”