Malignant fibrous histiocytoma in thoracic surgical practice

A single-institutional, multidisciplinary approach to primary sarcomas involving the chest wall requiring full-thickness resections

“…P rimary sarcomas that involve the chest wall are rare. 1,2 These tumors originate either in the bone or cartilage of the thoracic skeleton or in the surrounding soft tissues with direct invasion into the interspace or bone. Osias Aimar, in 1778, is believed to have performed the first resection of a chest wall tumor.…”

A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection

“…The most common histopathological diagnosis is chondrosarcoma [ 2 ]. Although MFH is the most common soft tissue sarcoma, it is rarely located on the thoracic wall and particularly on the sternum[ 4 , 5 ]. In a retrospective study of 64 years, nearly half of the 54 patients with primary sternum tumor were diagnosed with chondrosarcoma, while only one of these patients (1.8%) was diagnosed with MFH [ 2 ].…”

“…In establishing histopathological diagnosis, percutaneous fine needle biopsy is preferred because it is easily applied and has low risk of complications. However, variable morphological characteristics of MFH may render diagnosis challenging [ 5 ]. Nonaka et al have presented a similar patient in whom the preoperative diagnosis could not be established through percutaneous needle biopsy and due to the destruction in the sternum, complete surgical resection was preferred in the diagnosis and treatment of the patient [ 8 ].…”

Primary Malignant Fibrous Histiocytoma of the Lung

“…All the patients were operated on, and the appropriate anatomical resections with total lymphadenectomy were performed based on the perioperative diagnosis of malignancy. The role of chemotherapy and radiotherapy in MFH remains unclear and radical resection is a definite treatment for MFH [2,10,11,15,17]. Some patients receive radiotherapy or chemotherapy at some stage of their treatment; however, no consistent data are available on the effectiveness of these modalities [3,15,18].…”