Malignant Degeneration in Chronic Ulcerative Colitis

Exfoliative Cytology in Chronic Ulcerative Colitis

“…T h e presence of malignant-looking cells in rectal smears obtained by the I-s method in the absence of frank carcinoma reduces the usefulness of the procedure for the diagnosis of early rectal carcinoma in patients with active ulcerative colitis. 4. Further studies to evaluate the significance of the large bland, large active, and malignantlooking cells removed by the I-s method are clearly indicated.…”

Chronic Ulcerative Colitis in Childhood: A Follow-up Study

“…The recorded incidence of carcinoma varies, in adults, depending on whether the material is derived from medical or surgical sources. Thus in medical series Sloan, Bargen and Gage (1950) reported 109 instances of 259 ARCHIVES OF DISEASE IN CHILDHOOD neoplasm in 2,000 cases, Kiefer, Eytinge and Johnson (1951), nine in 458, Weckesser and Chinn (1953), four in 118, Banks, Korelitz andZetzel (1957), nine in 245, andCullinan andMacDougall (1957) six in 346, whereas from surgical sources Kiefer et al (1951) recorded 10 in 226, Lyons and Garlock (1951) nine in 226, Hurt (1954) two in 18, Bacon, Yang, Carroll, Cates, Villalba and McGregor (1956) 12 in 84, and Thorlakson (1956) 12 in 182. The tendency for malignant change to occur increases, not unexpectedly, with the duration of the colitis, and in the series reported by Lyons and Garlock (1951) 36% of those who had had the disease longer than 12 years developed carcinomata.…”

“…The tendency for malignant change to occur increases, not unexpectedly, with the duration of the colitis, and in the series reported by Lyons and Garlock (1951) 36% of those who had had the disease longer than 12 years developed carcinomata. This susceptibility to carcinoma of the large bowel has been variously estimated as from five times (MacDougall, 1954) to 66 times (Kiefer et al, 1951) that of the normal population. The growths may have multifocal origins (Gelber, Hawthorne and Gelb, 1955) and usually progress rapidly.…”

Surgical Management of Chronic Ulcerative Colitis

“…Actually, in most cases of per¬ sistently active ulcerative colitis for this long a period, indications other than fear of carcinoma are quite clear. 10 Several reports of perforation of the colon during steroid therapy for ulcerative colitis have been published.…”