Exfoliative Cytology in Chronic Ulcerative Colitis

Galambos, John T.; Massey, Barbary W.; Klayman, Melvin I.; Kirsner, Joseph B.

doi:10.1159/000200580

Cited by 3 publications

(4 citation statements)

References 1 publication

(1 reference statement)

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“…In the third trial diagnostic series unsatisfactory material was obtained from only one case of proven carcinoma. This improvement reflects the much greater care which was taken with the preparation of the patient in this third series, and is in accord with the reports of others (Galambos and Klayman, 1955; Raskin and others, 1958). …”

Section: The Methods O F Collectingsupporting

confidence: 90%

The diagnosis of carcinoma of the large bowel by exfoliative cytology

Oakland

1961

Journal of British Surgery

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Section: The Methods O F Collectingsupporting

confidence: 90%

The diagnosis of carcinoma of the large bowel by exfoliative cytology

Oakland

1961

Journal of British Surgery

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“…Therefore, care should be taken whenever cytological examination is performed in adnoma. In contrast, such very atypical cells as reported previously by Galambos et al (1956) and Boddington and Truelove (1956) appeared infrequently in ulcerative colitis in this series, while a great many of neutrophils together with multinucleated giant cells or plasma cells were characteristic of the active stage of ulcerative colitis (Watanabe et al 1977). Bemvenuti et al (1974) reported that 4 cases of cancer associated with ulcerative colitis were correctly diagnosed cytologically.…”

Section: Resultscontrasting

confidence: 56%

Cytological Diagnosis of Cancer of the Colon and Rectum

Watanabe

1978

Tohoku J. Exp. Med.

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of Cancer of the Colon and Rectum Tohoku J. exp. Med., 1978, 124(2), 169-176-Results of cytological examination in 120 cases of colon and rectum cancer during the 11-year period ending in 1968 prior to the practical use of fibercolonoscope were first studied.At that time, quite favorable results were obtained in cancer of the lower colon and the rectum, but the results were not so satisfactory in cancer of the right side of the colon. After 1969 when the fibercolonoscope was introduced into the clinical practice, the range of cytological diagnosis under direct vision was at once expanded to the entire colon. Consequently, diagnosis by the cytological method in 140 cases of cancer of the colon and rectum experienced in 6-year period between 1969 and 1974 revealed favorable results.The results of the cytological diagnosis in cancer of the right side of the colon, previously not always favorable, improved markedly after the introduction of the cytological method under direct vision through fibercolonoscope.When early cancer of the colon and rectum is defined as in early gastric cancer, 40 lesions in 36 patients were detected during the past 19 years. The rate of positive result in cases of early cancer obtained by various diagnostic methods was 83% by the cytological method, 78% by biopsy and 91% by polypectomy.In cases in which both biopsy and cytological method were used, one or both frequently gave positive results. These results would indicate the possibility of correct diagnosis in many cases through the combined use of the cytological method and biopsy, without polypectomy. cytological diagnosis; cancer of the colon and rectum Diagnosis of cancer of the colon and rectum is usually made by x-ray examina tion, proctosigmoidoscopy, biopsy and exfoliative cytology. In recent years, a newly developed fibercolonoscope has opened the possibility of direct observation as well as the possibility of cytological study under direct vision through an endoscope in lesions beyond the reach of proctosigmoidoscope.Since 1958 we have made the cytological studies at the Third Department of Internal Medicine, Tohoku University Hospital, for the purpose of detection of cancer of the colon and rectum in its early stage, using various cell sampling methods such as rectal swabbings, modified colon brush method, colonic lavage, and recently, biopsy-smear method under direct vision through the fibercolonoscope (Yamagata et al. 1961;Watanabe 1972). The purpose of this paper is to summarize our experiences and conclusions from these investigations during a 19-year period.

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“…These agents result in significant reparative changes greater than those easily recognizable as benign repair. The malignancy risk of cases assigned to the “atypical” category depends in part on the method for specimen procurement 2–15 . For specimens obtained by fine‐needle aspiration, malignancy risk of the “atypical” category is variable in published reports 2 .…”

Section: Discussionmentioning

confidence: 99%

“…Historically, the term “atypical” has been used to imply that changes are present precluding a definitive diagnosis of benign but are associated with a low level of concern that a malignancy is present. The term “atypia” has been widely utilized in the analysis of gastrointestinal brushings and in this context has generally been associated with reactive changes associated with inflammation or repair 5–7 . Some authors have used the term “atypical squamous metaplasia” to describe metaplastic squamous epithelium with cellular or nuclear features of the same type but to lesser degree than those seen in squamous cell carcinoma 8 .…”

Section: Historical and Theoretical Basis For The Term “Atypical”mentioning

confidence: 99%

Atypia in pulmonary cytology: Morphologic spectrum and causes

Layfield

Baloch

2021

Diagnostic Cytopathology

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Background The term “atypical” has had a long history of usage in cytology but has had variable definitions and usage. Most commonly the term was used to indicate a degree of cytomorphologic abnormality greater than that clearly due to reactive or reparative changes but not associated with a high concern on the part of the cytopathologist that a malignancy is present. The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology provided a foundation for using the category “Atypical” along with the category “Suspicious for Malignancy” to categorize the spectrum of morphologic changes ranging from those which are clearly benign to those that are clearly malignant. The two intermediate categories of “Atypical” and “Suspicious for Malignancy” have characteristic recommendations resulting in clinical utility for both categories. Conclusion The Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology represents a useful system with defined intermediate categories of Atypical and Suspicious for Malignancy.

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Exfoliative Cytology in Chronic Ulcerative Colitis

Cited by 3 publications

References 1 publication

The diagnosis of carcinoma of the large bowel by exfoliative cytology

The diagnosis of carcinoma of the large bowel by exfoliative cytology

Cytological Diagnosis of Cancer of the Colon and Rectum

Atypia in pulmonary cytology: Morphologic spectrum and causes

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