Malignant chondroid syringoma of the pinna

Aggarwal, Niharika; Deen, Suhail; Majhi, Urmila; Ramshankar, Vijayalakshmi

doi:10.4103/0972-3919.164057

Cited by 11 publications

(20 citation statements)

References 8 publications

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“…4 However, because of the possibility of benign cutaneous mixed tumor evolving into a malignant tumor, it is often managed surgically, with complete excision of the tumor with negative margins. 1 Adjuvant radiotherapy, with or without chemotherapy, has shown limited contributions. In a case of malignant cutaneous mixed tumor with pulmonary metastases, the patient showed a favorable response to high-dose-rate endobronchial brachytherapy.…”

Section: Discussionmentioning

confidence: 99%

“…1,3,4,6,7 While benign cutaneous mixed tumor occurs predominantly in males, malignant cutaneous mixed tumor has a female preference (3:2). 1 The mean age of patients at the time of diagnosis is 48 years, and can range from 13 to 84 years. 1 Prognosis of malignant cutaneous mixed tumor is variable, with the reported survival ranging from 9 weeks postoperatively to 12 years.…”

Section: Report Of a Casementioning

confidence: 99%

“…1 The mean age of patients at the time of diagnosis is 48 years, and can range from 13 to 84 years. 1 Prognosis of malignant cutaneous mixed tumor is variable, with the reported survival ranging from 9 weeks postoperatively to 12 years. 6 Because of its clinically ambiguous presentation, cutaneous mixed tumors may be confused with various other skin lesions.…”

Section: Report Of a Casementioning

confidence: 99%

“…Cutaneous mixed tumor (also known as "chondroid syringoma", although this is an older term which has fallen out of favor), is a benign appendageal tumor of the eccrine or apocrine glands consisting of both epithelial and mesenchymal elements. 1,2 The incidence of cutaneous mixed tumor is rare, composing <0.01% of all primary skin tumors. 3 The malignant counterpart is even more rare, and these malignant adnexal neoplasms typically lack distinctive clinical features.…”

mentioning

confidence: 99%

“…While benign cutaneous mixed tumor is often found in the head and neck region, malignant mixed tumor is more often found on the trunk and extremities, with few reported cases on the head and neck. 1,3,4 High rates of local recurrence and metastases have been reported with these tumors.…”

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Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis

Nguyen

2017

J Cutan Pathol

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Benign cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of the benign mixed tumor (pleomorphic adenoma) of salivary glands, consisting of both epithelial and mesenchymal elements. The incidence of cutaneous mixed tumor is rare, composing <0.01% of all primary skin tumors. Herein, we report a case of malignant mixed tumor which recurred in the right thumb 20 years after the reported initial diagnosis of a benign mixed tumor at this site. Histologically, the lesion consisted of highly atypical and infiltrative cells in cords and ductal structures, with an adjacent focus of residual benign mixed tumor present. Perineural invasion of multiple dermal and subcutaneous nerves was also seen. Immunohistochemical staining was strongly and diffusely positive for CK5/6 and p63, with patchy positive S100 and CK7 staining. Wide excision was performed, with no evidence of recurrence or metastasis 5 years later.

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Section: Discussionmentioning

confidence: 99%

Section: Report Of a Casementioning

confidence: 99%

Section: Report Of a Casementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Local recurrence of cutaneous mixed tumor (chondroid syringoma) as malignant mixed tumor of the thumb 20 years after initial diagnosis

Nguyen

2017

J Cutan Pathol

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Malignant chondroid syringoma: A systematic review

Zufall

Mark

Gru

2022

Skin Health and Disease

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Malignant Chondroid Syringomas (MCS) are very rare malignant tumours arising from cutaneous sweat glands, with only 51 reported cases in the literature. These tumours can metastasize and cause death if not treated adequately. While there are histological criteria to diagnose MCS tumours, there are no established criterion to determine which tumours are more or less likely to metastasize. A systematic review was performed to establish if any features of the primary MCS tumour are associated with risk of metastasis or patient mortality, as well as the efficacy of common treatment options. The literature search was performed using the Ovid Medline and Web of Science databases from inception through March 2020. This yielded 47 case reports corresponding to 51 unique patients. Statistical analysis of the collected data revealed none of the commonly accepted malignant histopathologic findings (including nuclear atypia and/or pleomorphism, mitotic figures, an infiltrative growth pattern, presence of satellite nodules, necrosis, and vascular and/or perineural invasion) of the primary tumour to be significantly more associated with metastatic risk or death. However, gross characteristics of the tumour, including size (greater than 5 cm) and truncal location of the primary lesion, were found to be associated with a higher risk of metastasis. The most effective treatment modality was wide local excision. Overall, primary MCS tumours, especially those greater than 5 cm or located on the trunk, should be treated with a wide local excision and followed closely to confirm no lesion recurrence or distant metastasis.

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