Malignant brenner tumor: A histologic, morphometrical, immunohistochemical, and ultrastructural study

Abstract

The histologic, morphometric, immunohistochemical, and ultrastructural study of a malignant Brenner tumor in a postmenopausal women presenting with vaginal bleeding is described. A comparison with transitional cell carcinomas is made, and the use of morphometry in grading the urothelial-like epithelium in malignant Brenner tumors is suggested. High preoperative urinary estrogen, low serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels and histologically confirmed atypical endometrial hyperplasia suggested a hyperestrogenism. The reduction in urinary estrogen and the increase in serum LH and FSH after tumor removal and the presence of aromatase activity detected in tumor microsomes confirmed that the tumor was synthesizing estrogen. Estrogen receptors were undetectable both by biochemical and histochemical analysis in the tumor.

Malignant Brenner Tumour – A Rare Entity

“…Benign Brenner tumour admixed with serous or mucinous carcinoma should not be diagnosed as Malignant Brenner tumour. Endometrial hyperplasia has been reported to coexist in 4-14% of women who have Brenner tumours [7] . Fox etalpresented cases of MBT with abnormal vaginal bleeding [8] .…”

Brenner tumor in pregnancy: Clinical approach and pathological findings

“…2 Malignant Brenner tumors are differentiated from transitional cell carcinomas of the ovary by the occurrence of an identifiable benign Brenner tumor next to the area of histologically malignant epithelium in the former. 1 Brenner tumors are mainly asymptomatic, and may have incidental findings, particularly if small. Clinical symptoms of a pelvic mass, such as pain or a palpable mass may be seen in tumors with larger dimensions.…”

“…Routine gynecological follow up is adequate. 1,3 The clinical and histological differentiation is important, because proliferative Brenner tumors have quite a favorable prognosis and may be treated in the same manner as the benign, whereas malignant Brenner tumors have a more guarded prognosis and require further intervention. In our case and the previous illustrated series, all cases were of a benign variety of Brenner tumor and conservative treatment and follow up was sufficient.…”

“…Tumors of borderline malignancy are less common and only about 1% of Brenner tumors are of malignant potential. 1 The nature and histogenesis of Brenner tumors has provoked controversy, but most authors agree that the epithelium resembles transitional epithelium. It has been hypothesized that the origin of these tumors is the coelomic epithelium that pass through a process of transitional metaplasia.…”

A Case of Bilateral Malignant Ovarian Brenner Tumor

“…Malign Brenner tümörleri solid veya mural nodüller içeren kistler şeklinde olabilir ve genelde ayırt edici özellikleri yoktur (7). Brenner Tümörlerinin %4-14'de endometrial hiperplazinin eşlik ettiği gösterilmiştir (8). Olgumuzda hastada endometrial patoloji saptanmamıştır.…”