Brenner tumor in pregnancy: Clinical approach and pathological findings

Abstract

The Brenner tumor is an uncommon ovarian tumor in pregnancy with only three previous cases in the English published reports. A 35-year-old woman delivered abdominally because of distress symptoms and a Brenner tumor was resected incidentally. Histological examination revealed a tumor composed of epithelial nests and areas of stromal luteinization. The patient was treated conservatively. Brenner tumor should be considered in the differential diagnosis of adnexal masses during pregnancy. These tumors are mainly benign and show typical luteinization associated with the hormonal milieu in pregnancy.

A Rare Case of Bilateral Malignant Brenner Tumors of the Ovaries Associated with Peritoneal Effusion

“…Walthard cell nest is formed by metaplastic transitional epithelium and trapped in the tissues adjacent to the fallopian tubes, where most Brenner tumors are located. From the perspective of embryology, most scholars believe that the ovarian MBT is derived from the surface epithelium, which is generated by the the epithelium [12][13] .…”

“…The extreme rarity of the malignant Brenner tumors can be explained by the following proofs [4,[12][13] . adjacent to the endometriosis cyst were considered endometrioid tumor [14][15] .…”

“…Kondi-Pafiti et al [14] studied 30 cases of ovarian Brenner tumors immunohistochemically and found that all cases expressed CK7,but did not express CK20,while WT-1 was focally positive in five cases. A casereported that p63 was positive in benign and borderline ovarian Brenner tumors, whereas p16 and p53 were negative in both types of tumors [13] .Malignant Brenner tumors need to be differentiated from metastatic transitional cell carcinoma, which is diagnosed based on the history of a tumor in the urinary system and the immunohistochemical markers.…”

Tumor De Brenner Bilateral Benigno

“…Es una neoplasia poco frecuente (constituye el 1,5-2,5% del total de neoplasias ováricas) generalmente unilateral (existiendo mayor tendencia a presentarse en el lado izquierdo) y el bilateral es muy raro, constituyendo entre el 3,7 y el 8% de todos los casos publicados (3). Afectan con mayor frecuencia a mujeres en la quinta década de la vida y suelen ser asintomáticos, aunque en ocasiones debutan con síntomas endocrinos (4).…”

“…El tumor de Brenner es sólido y se puede asociar a quistes (mucosos, serosos o endometroides) constituyendo tumores epiteliales mixtos. La gran mayoría de los tumores de Brenner son benignos, ya que los tumores de Brenner de tipo borderline, maligno y el carcinoma de células transicionales son excepcionales (4).…”