Malignant bone tumors in Kuwait

Katchy, K.C.; Ziad, Fouzia; Alexander, Susan; Gad, Hossam; Mota'al, M. Abdel

doi:10.1007/s00264-005-0014-6

Cited by 20 publications

(17 citation statements)

References 12 publications

(11 reference statements)

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“…In addition, unlike the presented study, which found osteosarcoma to be the most common tumour observed, the most common tumour detected was Ewing sarcoma. 20 In India, the annual incidence of Ewing sarcoma was 1.6 per 1,000,000 in males and 1.0 per 1,000,000 in females. 21 …”

Section: Discussionmentioning

confidence: 99%

Primary bone sarcomas in KSA: A Saudi tumor registry review

Aljuhani

Alanazi

Alghafees

2021

Journal of Taibah University Medical Sciences

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Objectives The geographical incidence of tumours is usually influenced by the environment, race, and culture. This study aimed to report the incidence and differences in tumour type, site of origin, and mortality across gender, regions, age, and the different characteristics of tumour types. Methods This retrospective cohort study included all patients diagnosed with primary bone sarcomas from January 1, 2013, to December 31, 2017. Frequencies and percentages were generated for categorical variables. Means and standard deviations were calculated for quantitative variables. A chi-squared test was used to detect differences among categorical variables. Student-t, ANOVA, and Tukey tests were used to detect differences among quantitative variables. Lastly, we calculated the incidence of each tumour type. Results Of 451 patients, 248 (55%) had osteosarcomas; 160 (35.5%) had Ewing's sarcoma, and 43 (9.5%) had chondrosarcoma. The incidence was 1.56 cases per 1,000,000 per year for osteosarcoma, 0.95 cases per 1,000,000 per year for Ewing's sarcoma, and 0.27 cases per million per year for chondrosarcoma. The three-year survival rate was 82.30%. Significant differences in tumour type, origin site, and three-year survival across age and gender were detected. Similarly, significant differences were also noted in origin site, grade, basis of diagnosis, and lateralisation across tumour types. Conclusions In our study, the observed bone sarcoma incidence rates were lower than the ones reported worldwide. Understanding the pattern of tumour behaviour in the region will help develop a risk and response-based treatment plan for early decision-making.

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Section: Discussionmentioning

confidence: 99%

Primary bone sarcomas in KSA: A Saudi tumor registry review

Aljuhani

Alanazi

Alghafees

2021

Journal of Taibah University Medical Sciences

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“…Reports from other parts of the world show that the primary bone tumors are relatively uncommon lesions constituting less than 1% of all cancers [1,2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Accurate diagnosis, proper staging and appropriate treatment are thus necessary to ensure maximum patient survival and maintain optimal function of the affected body parts. Primary bone tumors are relatively uncommon lesions constituting less than 1% of all cancers worldwide [1], [2], [3]. Some of these primary bone tumors display marked intra and international variations in incidence, size and age distribution [3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Primary bone tumours in Kashmir valley a retrospective histopathological study

Wani

Ashai²,

Banday³

et al. 2014

IJBAS

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The present study was carried out in the postgraduate department of Pathology at Government Medical College, Srinagar, India, to study the histopathological pattern of primary bone tumors in Kashmir valley over a period of 15 years. During this study, 373 histologically proven primary bone tumors were analyzed. Out of these, 298 were benign (79.89%) and 75 were malignant (20.10%). Peak incidence was in the second and third decade of life with male predominance. Among the malignant tumors, the highest incidence was that of Osteosarcoma (52%), followed by Ewing's sarcoma (24%) and Chondrosarcoma (14%). Osteochondroma (49%) was the most frequent tumor in the benign category. The most commonly affected bones were femur, tibia and humerus in that order. Comparison with similar studies from other parts of the globe indicate that the relative frequency of primary bone tumors appears to be low but shows a rising trend in the last 10 years in this part of the world.

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“…Peripheral primitive neuroectodermal tumors (pPNET) are malignant small round-cell tumors that occur predominantly in bones and soft tissue of children and young adults [ 1 ], only in rare cases in other organs and in older patients [ 2 ]. pPNET belong to the Ewing's sarcoma family of tumors and share the same immunohistochemical profiles and molecular genotypes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report

et al. 2009

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IntroductionPeripheral primitive neuroectodermal tumors of the urinary bladder are rare and tend to occur in an older age group than do their counterparts in bones and soft tissue.Case presentationWe report a case of peripheral primitive neuroectodermal tumor of the urinary bladder in a 67-year-old woman of Arab origin. She had undergone transurethral resection followed by chemotherapy because of pulmonary metastasized muscle-invasive squamous cell carcinoma of the bladder in 2005. One year later, she first presented with a history of repeated hematuria in our institution. Performing cystoscopy any tumor could be detected. Control cystoscopy two months later showed a tumor mass of 3 cm in diameter at another location than described for the first tumor. After perforating by transurethral resection partial bladder resection had to be done. Tissue specimen after pathological analysis revealed a peripheral primitive neuroectodermal tumor with tumor cells reactive to cluster of differentiation 99, neuron-specific enolase and S100 protein and stained negative for other markers such as cytokeratins, epithelial membrane antigen, desmin, smooth muscle actin, chromogranin and leucocyte common antigen. Staging computerized tomography was especially free from any hint on organ metastasis, but the patient died due to a cardiac problem only a few months later.ConclusionsTo the best of our knowledge, we report the eighth case of bladder peripheral primitive neuroectodermal tumors in literature and the first concerning an Arab patient. It is also the first presentation of a peripheral primitive neuroectodermal tumor patient with a history of squamous cell carcinoma of the bladder. As in other cases, expression of single-chain-type 1 glycoprotein and neural markers was positive and the disease was at an advanced stage at the time of diagnosis.

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Malignant bone tumors in Kuwait

Cited by 20 publications

References 12 publications

Primary bone sarcomas in KSA: A Saudi tumor registry review

Primary bone sarcomas in KSA: A Saudi tumor registry review

Primary bone tumours in Kashmir valley a retrospective histopathological study

Peripheral primitive neuroectodermal tumor of the urinary bladder in an Arab woman with history of squamous cell carcinoma: a case report

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