Malignancy of the Larynx in a Child

Abstract

Squamous cell carcinoma ofthe larynx in children is rare. The management of laryngeal malignancy is more difficult in children than adults for several reasons: the aggressive nature ofa tumor that is often diagnosed late in children; the delicacy of pediatric anatomic stru ctures; intraoperative blo od loss ; long-term post-treatment complications; and psychological factors pa rticular to children. A trach eostomized 13-year-old boy came to us with a 4-month history ofhoarsen ess, breathing diffi culty, and swelling in the neck. A detailed examination rev ealed that a transglottic tumor had infiltrated the thyroid and cricoid cartilage, the upper two tra cheal rings, and the thyroid gland. Such an infiltration has not been previously repo rted. The lesion proved to be a well-differentiated squamous cell carcinoma. We performed a widefield total laryngectomy, whi ch was f ollowed by radiotherapy. Unfortunately, the child survived only 3 years postoperatively.

Castleman’s disease mimicking lymph node metastases in a young woman with laryngeal cancer

“…Laryngeal carcinoma in patients aged below 40 years accounts for less than 3% of all laryngeal cancer cases [7–9]. The rarity of the disease among adolescents hampers the diagnosis and may lead to delay in treatment, as was the case in our patient.…”

Pediatric laryngeal carcinoma in a heterozygous carrier of Fanconi anemia

“…Surgical management with partial or total laryngectomy (and effect on psychosocial development and laryngeal function) must be weighed against the risk of secondary malignancies with radiation therapy. In balance, presentation at a more advanced stage corresponds with a poorer overall outcome …”

Laryngeal Squamous Cell Carcinoma in a 13 Year-Old Child Associated with Human Papillomaviruses 16 and 18: A Case Report and Review of the Literature

“…The management of laryngeal malignancy in children is more difficult than in adults because the tumors tend to behave more aggressively, likely due to their delayed diagnosis [13]. Additionally, pediatric anatomic structures are delicate, and there may be long-term complications following treatment, including psychosocial factors specific to adolescents [13].…”

“…Additionally, pediatric anatomic structures are delicate, and there may be long-term complications following treatment, including psychosocial factors specific to adolescents [13]. Treatment protocols have not been well-established due to the scarcity of cases, but it is typically based upon the stage of the tumor, laryngeal cartilage involvement, and metastases [13]. SCC in children tends to respond to treatment in a way similar to that of SCC in adults [10, 11].…”