Malignancy mimicking bisphosphonate-associated osteonecrosis of the jaw: a case series and literature review

Gander, Thomas; Obwegeser, Joachim A.; Zemann, Wolfgang; Grätz, K W; Jacobsen, Christine

doi:10.1016/j.oooo.2013.08.028

Cited by 30 publications

(15 citation statements)

References 23 publications

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“…In a 2001 case and literature review of 121 patients with BRONJ who were treated surgically, three patients were found to have underlying neoplasia mimicking BRONJ. 30 In this dog, biopsy of the right mandible 13 months before euthanasia did not identify histologic evidence of OS based upon an incisional biopsy. However, small biopsies do run the risk of missing underlying malignancy, and it is not possible to determine if this dog developed OS secondary to chronic osteomyelitis, or if metastatic OS and osteomyelitis developed concurrently.…”

Section: Discussionmentioning

confidence: 74%

“…The concurrent diagnosis of osteonecrosis associated with underlying osteomyelitis and tandem with OS were unexpected histologic findings, as people diagnosed with BRONJ, underlying malignancy has been identified in only a small number of cases. In a 2001 case and literature review of 121 patients with BRONJ who were treated surgically, three patients were found to have underlying neoplasia mimicking BRONJ . In this dog, biopsy of the right mandible 13 months before euthanasia did not identify histologic evidence of OS based upon an incisional biopsy.…”

Section: Discussionmentioning

confidence: 85%

See 1 more Smart Citation

Zoledronate‐Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

Lundberg

Roady

Somrak

et al. 2016

Veterinary Internal Medicne

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 85%

Zoledronate‐Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

Lundberg

Roady

Somrak

et al. 2016

Veterinary Internal Medicne

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“…In the bibliography consulted, we have only found the relationship between the use of BP and esophageal carcinoma [12]. Recently, authors like Gander report three cases of BRONJ with bone exposure underlying soft tissue of areas of malignization [13].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Epidermoid Carcinoma on Mandibular Osteonecrosis Due to Oral Bisphosphonates in the Treatment of Osteoporosis. Case Report and Review of Literature

JoseDarío¹,

M²,

Cariati³

et al. 2018

JRAD

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“…En effet, les antécédents médicaux de la patiente précisaient l'existence d'un cancer du sein traité en 1967 et un lymphome marginal en cours de surveillance. La littérature rapporte quelques cas de métastases maxillaires des tumeurs malignes pouvant mimer l'ostéonécrose associée aux bisphosphonates [17]. Seule l'étude anatomopathologique du séquestre osseux permet de confirmer le diagnostic d'ostéonécrose et d'écarter tout caractère de malignité.…”

Section: Discussionunclassified

Ostéonécrose des maxillaires : quand l’ancien traitement avec bisphosphonates est méconnu

Renoux

Folliguet

Nguyen

et al. 2014

Med Buccale Chir Buccale

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Résumé -Introduction :La personne âgée est atteinte de polypathologies et polymédiquée. Les prescriptions sont faites par plusieurs médecins qui s'ignorent réciproquement, ce qui augmente le risque d'effets adverses. Observation : Le cas d'une patiente de 91 ans vivant dans un établissement d'hébergement pour personnes âgées dépendantes est rapporté. Quatre mois après une perfusion de zolédronate suite à une chute avec tassement vertébral, elle a consulté pour une gêne maxillaire gauche, ce qui a permis de découvrir un foyer d'ostéonécrose spontanée maxillaire. Un deuxième foyer d'ostéonécrose, mandibulaire, a été diagnostiqué trois semaines plus tard. Considérant l'âge de la patiente et l'absence de troubles fonctionnels, seul un débridement chirurgical superficiel a été réalisé. Discussion : L'apparition d'ostéonécroses spontanées bimaxillaires quatre mois après une perfusion unique de zolédronate étant peu probable, la recherche approfondie des antécédents de la patiente a permis de retrouver une prise de trois bisphosphonates oraux pendant sept ans sans aucun examen et suivi bucco-dentaire. L'interrogatoire médical des patients âgés atteints de troubles cognitifs étant difficile, la recherche de tous les médecins prescripteurs est nécessaire. Conclusion : La prise en charge de l'ostéonécrose associée aux bisphosphonates étant complexe, le chirurgien-dentiste joue un rôle important dans la prévention de cette pathologie.Abstract -Osteonecrosis of the jaws: when past bisphosphonates therapy is unknown. Introduction: Older people have multiple morbidities and are polymedicated. The medicines are prescribed by several doctors who are unaware of each other, hence the increased risk of adverse effects. Observation: We report the case of an institutionalized 91-year-old female patient. Following a fall resulting in a vertebral compression fracture, she received an infusion of zoledronic acid. Four months after this treatment, she consulted for left maxillary discomfort. A voluminous bone sequestrum revealed a maxillary osteonecrosis area. Right mandibular osteonecrosis was diagnosed three weeks later. Considering the patient's age and the lack of functional impairment, surgical debridement was the only procedure performed. Discussion: The emergence of spontaneous maxillary osteonecrosis four months after a single infusion of bisphosphonate being implausible, we searched her medical records for the physicians who treated the patient before her institutionalization. We found three oral bisphosphonate medications during seven years. No oral examination was performed during this therapy. The diagnosis of jaw osteonecrosis should lead the oral surgeon to look for past bisphosphonate therapy among other possible etiologies of this pathology. Indeed, this treatment is often forgotten by patients suffering from cognitive impairment. Conclusion: As the management of bisphosphonate-related osteonecrosis of the jaws is difficult, the oral surgeon has an important role in the prevention of this pathology. Mots clés :bisphospho...

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Malignancy mimicking bisphosphonate-associated osteonecrosis of the jaw: a case series and literature review

Cited by 30 publications

References 23 publications

Zoledronate‐Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

Zoledronate‐Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

A Rare Case of Epidermoid Carcinoma on Mandibular Osteonecrosis Due to Oral Bisphosphonates in the Treatment of Osteoporosis. Case Report and Review of Literature

Ostéonécrose des maxillaires : quand l’ancien traitement avec bisphosphonates est méconnu

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