Malignancies in Autoimmune Rheumatic Diseases – A Mini-Review

Szekanecz, Zoltán; Szekanecz, Éva; Bakó, G; Shoenfeld, Yehuda

doi:10.1159/000314634

Cited by 54 publications

(61 citation statements)

References 71 publications

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“…(21,22) For example, it has been postulated that sustained excessive salivary and lacrimal gland B-cell stimulation, and impaired B-cell apoptosis in patients with Sjögren's syndrome may lead to tumorigenesis and clonal expansion of B-cells that ultimately leads to the development of lymphomas. (21) The relationship between chronic inflammation and carcinogenesis in RP patients may be elucidated by studying inflammatory markers such as plasma cytokines, lipid peroxides, p53, BAX, cyclins and caspases.…”

Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis in Singapore: a case series and review of literature

Chuah¹,

Lui²

2017

smedj

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INTRODUCTIONRelapsing polychondritis (RP) is a rare immune-mediated condition, which is characterised by recurrent and progressive inflammation of cartilaginous structures and proteoglycan-rich structures.(1) RP particularly affects the cartilaginous areas of the ears and nose, and it is not uncommon for the eyes, joints and respiratory tract to be affected as well. RP can occur in isolation or in association with other diseases. The objective of the present study was to describe the clinical presentation, treatment and outcome of patients with RP who were seen at a large tertiarycare academic medical institution in Singapore. METHODSSingapore General Hospital is a 1,700-bed tertiary-care academic medical institution in Singapore. In this study, we retrospectively reviewed the medical records of all patients diagnosed with RP at the Department of Rheumatology and Immunology between January 2005 and December 2013. The medical records that were retrieved and reviewed included information on both inpatient and outpatient visits.The diagnosis of RP was made according to the modified McAdam criteria. The clinical presentation, laboratory results, treatment response and clinical outcome of the patients were recorded using a standardised data collection sheet; the collected data was then summarised. This study design received approval from the local institutional review board. RESULTSA total of ten patients with RP symptoms were seen at the Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, during the study period. Five of these patients fulfilled the modified McAdam criteria, while the remaining five patients fulfilled only part of the diagnostic criteria and were thus classified as probable cases of RP. The average age of onset of RP was 48 (range 22-72) years and the average duration of follow-up was 3.5 years (range 17 months-7 years). The patients were all of Chinese ethnicity and the female-to-male ratio was 7:3. The clinical presentation, laboratory results, and therapy and clinical outcomes of the ten patients are summarised in Table I.

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Section: Discussionmentioning

confidence: 99%

Relapsing polychondritis in Singapore: a case series and review of literature

Chuah¹,

Lui²

2017

smedj

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“…They may be an initial presentation, in such cases the diagnosis may be difficult and needs a high index of suspicion. However they can be used as a clue for the underlying malignancy [5].…”

Section: Discussionmentioning

confidence: 99%

Acute Lymphoblastic Leukemia in Systemic Lupus Erythematosus Disguise: A Case Report

Ragab¹

2017

J Musculoskelet Disord Treat

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“…The presence of autoantibodies against nuclear proteins and doublestranded deoxyribonucleic acid (ds-DNA) in the serum of people with paraneoplastic RD is used as evidence for this suggestion. [3] …”

Section: Pathogenesismentioning

confidence: 99%

“…Hyperuricemia can be prevented by adequate hydration and allopurinol treatment before chemotherapy. [3] …”

Section: Secondary Goutmentioning

confidence: 99%