Paraneoplastic Rheumatic Disorders

How to investigate new-onset polyarthritis

“…If the patient belongs to the elderly age group, the possibility of underlying malignancy must be ruled out by appropriate investigations. Paraneoplastic polyarthritis has no characteristic picture to provide a clue [14]. A high index of suspicion is required.…”

Rheumatologic Diseases as Paraneoplastic Syndromes - A Paradigmatic Case

“…They can result from bone and joint invasion by the tumor (metastasis to the musculoskeletal system) [2][3][4], synovial reaction to neoplastic cells nearby [3,4], hemorrhage into the joint [4], secondary gout [3,4], complications from cancer treatments [2], neoplasia secondary to rheumatic diseases [2], malignancies secondary to immunosuppressive [2], and finally paraneoplastic syndromes [2][3][4]. This paper will focus on the last one: rheumatic diseases as paraneoplastic syndrome, which consist on symptoms caused by the malignancy, not directly related to the tumor mass or the metastasis [2]. They occur in 10% at the time of diagnosis, but almost 50% on the course of the neoplasia [2,3].…”

“…This paper will focus on the last one: rheumatic diseases as paraneoplastic syndrome, which consist on symptoms caused by the malignancy, not directly related to the tumor mass or the metastasis [2]. They occur in 10% at the time of diagnosis, but almost 50% on the course of the neoplasia [2,3]. Most paraneoplastic syndromes are endocrine, but rheumatic, as well as others, are also observed [5].…”

“…hypothesized: 1) Both neoplasia and rheumatic disease have the same trigger [2], 2) Toxins produced by the tumor trigger inflammation and therefore the rheumatic disease [2], 3) Paraneoplastic rheumatic syndromes consist on hypersensitivity reactions, against the intracellular antigens eliminated by apoptotic cancer cells [6], 4) Rheumatic paraneoplastic diseases represent a successful tumor immunosurveillance [7].…”

Acute Lymphoblastic Leukemia in Systemic Lupus Erythematosus Disguise: A Case Report

“…The paraneoplastic RD usually precede the onset of the malignancy by months or years, and they improve once CASE REPORT treatment is initiated for the underlying malignancy [1].…”