Malic acid: A convenient precursor for the synthesis of peptide secondary structure mimetics

Imaging mass spectrometry in transmission geometry

“…Compound 26 was then oxidized to the aldehyde 27 . The C26–C35 side chain required for the construction of the complete lasonolide A skeleton was obtained as the phosphonium salt 30 from the known acetonide 28 14 and alcohol 29 15 by acid‐mediated esterification, followed by silylation and nucleophilic substitution with PPh 3 . The Wittig olefination of 27 and 30 was most effective in the presence of KHMDS, and the protected lasonolide A 31 was desilylated uneventfully to produce the natural (+)‐lasonolide A ( 1 ), all physical and spectroscopic data of which were identical to those reported in the literature 1.…”

Synthesis and Chemistry of α‐Hydrazino Acids

“…Their reactions occur in mild conditions (0 C) with sulfonates prepared from a-hydroxy esters and with inversion of configuration (Scheme 2.4) [22,67,96,97]. Their reactions occur in mild conditions (0 C) with sulfonates prepared from a-hydroxy esters and with inversion of configuration (Scheme 2.4) [22,67,96,97].…”

(S)-(2,2-Dimethyl-5-oxo-1,3-dioxolan-4-yl)acetic acid

“…The crystal structures of at least one simple dioxolanone derivative of (À)-malic acid is also known (Pang et al, 1997). For related literature, see: Green et al (1995); Kim et al (1997); Mulzer et al (2000); Ohfune et al (1981); Oida et al (1989); Shioiri et al (1995Shioiri et al ( , 1997; Stocksdale et al (2005).…”

“…Acta Cryst. C41, 956-959. and unnatural synthetic targets (Green et al, 1995;Kim et al, 1997;Mulzer et al, 2000). The reported syntheses of many phytosiderophores and their analogs have utilized the title compound (I) (Ohfune et al, 1981;Shioiri et al, 1995;Shioiri et al, 1997).…”