Malformations, choristomas, and hamartomas of the gastrointestinal tract and pancreas

Johncilla, Melanie; Yantiss, Rhonda K.

doi:10.1053/j.semdp.2018.11.004

Cited by 7 publications

(10 citation statements)

References 94 publications

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“…The term choristoma is derived from the Greek root “choristos,” meaning separated and also means mass or tumor. The term is synonymous with heterotopia and ectopia, which are defined as the proliferation of normal cells in an abnormal location [ 1 ] and an ectopic, histologically normal mature tissue. [ 18 ] Hamartoma is defined as a lesion containing mature and well-differentiated ectoderm and mesoderm derivatives that appear in abnormal locations [ 2 , 19 ] ; usually, 1 component dominates.…”

Section: Discussionmentioning

confidence: 99%

“…Choristoma is a tumor-like structure composed of normal tissue located at an abnormal site. [ 1 ] While it can occur anywhere in the body, it is more frequently observed in the head and neck region, especially in the pituitary gland [ 2 ] and oral cavity. [ 3 ] Intraspinal choristomas are rare and, to the best of our knowledge, only 2 cases have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Intraspinal choristoma in the lumbar region: A case report

Yang¹,

Liang²,

Wang³

et al. 2022

Medicine

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Rationale: Intraspinal choristoma is a relatively uncommon intervertebral canal tumor. Prior to our reports, only 2 cases of intraspinal choristoma had been reported. Because this disease is not common and looks like a mass of fatty tissue on the magnetic resonance imaging (MRI), intraspinal choristoma can be easily misdiagnosed as teratomas or lipomas (like the case of this article presenting) without a pathology report. So if a lumber intraspinal lesion is discovered in a clinical examination, intraspinal choristoma should be considered as a differential diagnosis. We present a case of intraspinal choristoma that is unlike any other reported case. Patient concerns: A 35-year-old woman with left lower extremity hypoesthesia and burning-like pain in the lumbar region for 1 month visited the local hospital for plain lumbar spine MRI. The patient was diagnosed with a lumbar space-occupying lesion. A second plain lumbar spine MRI scan and a MRI scan with enhancement were performed in our hospital to confirm the presence of a congenital lipoma in the spinal canal. A postoperative biopsy of the lumbar spinal mass indicated that the mass was an intraspinal choristoma located in the spinal canal. Diagnosis: Intraspinal choristoma. Intervention: The lesion was surgically removed, and follow-up plain and enhanced MRI images of the patient’s lumbar spine were obtained. Outcomes: After surgery, the patient no longer experienced the burning pain in her lumbar region or the left lower extremity hypoesthesia when the patient was discharged. And there was no evidence of recurrence 2 years after the surgery. Lessons: The MRI presentation of intraspinal choristoma is similar to intraspinal lipoma. Therefore, a pathological assessment is critical to provide an accurate diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intraspinal choristoma in the lumbar region: A case report

Yang¹,

Liang²,

Wang³

et al. 2022

Medicine

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“…Los coristomas son un hallazgo común en el tracto gastrointestinal, y se encuentran de manera accidental durante exámenes de imágenes como tomografías e invasivos como endoscopia. 9 El tejido heterotópico puede ocurrir en cualquier ubicación del recorrido gastrointestinal, siendo los sitios más frecuentes estomago e intestino delgado. 1 El páncreas aberrante o heterotópico, es una masa aislada de tejido pancreático, separada completamente del órgano principal, donde se produce embriogénesis propia, pero se desconoce su modo de desarrollo.…”

Section: Discussionunclassified

“…Sabemos de la posibilidad de degeneración maligna que este tejido ectópico puede sufrir y es por ello que de forma preventiva se sugiere controlar al paciente periódicamente después del procedimiento quirúrgico, para detectar eventuales recidivas, aunque es raro y poco reportado. 8,9…”

Section: Discussionunclassified

Coristoma pancreático dentro de un divertículo duodenal: a propósito de un caso

Neyra-León¹,

Palomino²,

Monge³

et al. 2021

AMC

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El coristoma pancreático, o páncreas heterotópico, es una condición rara en gastroenterología. Esta entidad consiste en el hallazgo de tejido pancreático aberrante, en alguna zona del tracto gastrointestinal, sin continuidad vascular o anatómica con el páncreas normal, es poco reportado y presenta sintomatología variable.Presentamos el caso de un individuo de 46 años con dolor abdominal a quien se le encontró mediante exámenes invasivos un divertículo duodenal, el cual al examen histopatológico e inmunohistoquímico mostró un coristoma pancreático.

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“…Pancreatic heterotopia/ectopia (PE), defined as the presence of pancreatic tissue outside its physiological location and without vascular or other anatomical connections to the native pancreas, is a frequent condition, largely occurring within the gastrointestinal tract 64 . It is widely accepted that most ectopic pancreatic rests, with the exception of pancreatic metaplasia in chronic atrophic gastritis, represent congenital heterotopias, rather than metaplasias 64 .…”

Section: Pancreasmentioning

confidence: 99%

Congenital anomalies of the gastrointestinal tract: the liver, extrahepatic biliary tree and pancreas

et al. 2022

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Summary Congenital anomalies of the liver, biliary tree and pancreas are rare birth defects, some of which are characterized by a marked variation in geographical incidence. Morphogenesis of the hepatobiliary and pancreatic structures initiates from two tubular endodermal evaginations of the most distal portion of the foregut. The pancreas develops from a larger dorsal and a smaller ventral outpouching; emergence of the two buds will eventually lead to the fusion of the duct system. A small part of the remaining ventral diverticulum divides into a “pars cystica” and “pars hepatica”, giving rise to the cystic duct and gallbladder and the liver lobes, respectively. Disruption or malfunctioning of the complex mechanisms leading to the development of liver, gallbladder, biliary tree and pancreas can result in numerous, albeit fortunately relatively rare, congenital anomalies in these organs. The type and severity of anomalies often depend on the exact moment in which disruption or alteration of the embryological mechanisms takes place. Many theories have been brought forward to explain their embryological basis; however, no agreement has yet been reached for most of them. While in some cases pathological evaluation might be more centered on macroscopic evaluation, in other instances small biopsies will be the keystone to understanding organ function and treatment results in the context of congenital anomalies. Thus, knowledge of the existence and histopathological characteristics of some of the more common conditions is mandatory for every pathologist working in the field of gastrointestinal pathology.

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Malformations, choristomas, and hamartomas of the gastrointestinal tract and pancreas

Cited by 7 publications

References 94 publications

Intraspinal choristoma in the lumbar region: A case report

Intraspinal choristoma in the lumbar region: A case report

Coristoma pancreático dentro de un divertículo duodenal: a propósito de un caso

Congenital anomalies of the gastrointestinal tract: the liver, extrahepatic biliary tree and pancreas

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