Male Wistar rats are more susceptible to lasting social anxiety than Wild-type Groningen rats following social defeat stress during adolescence

Vidal, Jose; Buwalda, Bauke; Koolhaas, Jaap M.

doi:10.1016/j.beproc.2011.08.005

Cited by 43 publications

(24 citation statements)

References 31 publications

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“…Socially defeated rats demonstrate increased anxiety in adulthood [49]. In contrast, adolescent male rats exposed to social defeat exhibit reduced anxiety and more efficient risk assessment in the elevated plus-maze test as adults [50].…”

Section: Discussionmentioning

confidence: 96%

Extended Effect of Chronic Social Defeat Stress in Childhood on Behaviors in Adulthood

et al. 2014

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Individuals exposed to social stress in childhood are more predisposed to developing psychoemotional disorders in adulthood. Here we use an animal model to determine the influence of hostile social environment in adolescence on behavior during adult life. One-month-old adolescent male mice were placed for 2 weeks in a common cage with an adult aggressive male. Animals were separated by a transparent perforated partition, but the adolescent male was exposed daily to short attacks from the adult male. After exposure to social stress, some of the adolescent mice were placed for 3 weeks in comfortable conditions. Following this rest period, stressed young males and adult males were studied in a range of behavioral tests to evaluate the levels of anxiety, depressiveness, and communicativeness with an unfamiliar partner. In addition, adult mice exposed to social stress in adolescence were engaged in agonistic interactions. We found that 2 weeks of social stress result in a decrease of communicativeness in the home cage and diminished social interactions on the novel territory. Stressed adolescents demonstrated a high level of anxiety in the elevated plus-maze test and helplessness in the Porsolt test. Furthermore, the number of dividing (BrdU-positive) cells in the subgranular zone of the dentate gyrus was significantly lower in stressed adolescents. After 3 weeks of rest, most behavioral characteristics in different tests, as well as the number of BrdU-positive cells in the hippocampus, did not differ from those of the respective control mice. However, the level of anxiety remained high in adult males exposed to chronic social stress in childhood. Furthermore, these males were more aggressive in the agonistic interactions. Thus, hostile social environment in adolescence disturbs psychoemotional state and social behaviors of animals in adult life.

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Section: Discussionmentioning

confidence: 96%

Extended Effect of Chronic Social Defeat Stress in Childhood on Behaviors in Adulthood

et al. 2014

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“…In general, the experience of repeated stressors such as chronic variable stress (Ilin and Richter-Levin, 2009; Jacobson-Pick and Richter-Levin, 2010; Jacobson-Pick and Richter-Levin, 2012; Wilkin et al, 2012), elevated platform stress (Avital et al, 2006; Avital and Richter-Levin, 2005), social instability (Green et al, 2012; Mathews et al, 2008; McCormick et al, 2008; Schmidt et al, 2010a; Schmidt et al, 2010b; Schmidt et al, 2007; Sterlemann et al, 2008), social defeat procedures (Bourke and Neigh, 2011; Vidal et al, 2007; Vidal et al, 2011a; Vidal et al, 2011b; Weathington et al, 2012), and predator odors (Bazak et al, 2009; Cohen et al, 2007; Tsoory et al, 2007; Wright et al, 2008; Wright et al, 2012a; Wright et al, 2012b) increases anxiety-like behaviors in male and female rats and mice in adulthood (Table 2; for further review see McCormick and Green, 2012). The increases in anxiety-like behaviors are typically indicated by decreases in the time spent in the open arm of the elevated plus maze (McCormick and Green, 2012; McCormick et al, 2008; Schmidt et al, 2007; Sterlemann et al, 2008; Tsoory et al, 2007; Uys et al, 2006a).…”

Section: Adrenal Steroidsmentioning

confidence: 99%

“…Social instability stress in the early pubertal period also increases open field anxiety and decreases social interaction in adult male rats, while maintaining exploratory behavior (Green et al, 2012). Social instability and social defeat also lead to a decrease in social interactions in adulthood (Green et al, 2012; Vidal et al, 2007; Vidal et al, 2011a; Vidal et al, 2011b). While a few studies report lack of effect of stressors during pubertal development on locomotor or exploratory behavior, these stressors began on P30 and continued until well into adulthood (Peleg-Raibstein and Feldon, 2011; Toth et al, 2008a; Toth et al, 2008b), perhaps missing an earlier vulnerable period.…”

Section: Adrenal Steroidsmentioning

confidence: 99%

Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes

Holder

Blaustein

2014

Frontiers in Neuroendocrinology

199

143

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Puberty and adolescence are major life transitions during which an individual’s physiology and behavior changes from that of a juvenile to that of an adult. Here we review studies documenting the effects of stressors during pubertal and adolescent development on the adult brain and behavior. The experience of complex or compound stressors during puberty/adolescence generally increases stress reactivity, increases anxiety and depression, and decreases cognitive performance in adulthood. These behavioral changes correlate with decreased hippocampal volumes and alterations in neural plasticity. Moreover, stressful experiences during puberty disrupt behavioral responses to gonadal hormones both in sexual performance and on cognition and emotionality. These behavioral changes correlate with altered estrogen receptor densities in some estrogen-concentrating brain areas, suggesting a remodeling of the brain’s response to hormones. A hypothesis is presented that activation of the immune system results in chronic neuroinflammation that may mediate the alterations of hormone-modulated behaviors in adulthood.

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“…These ratios are also a function of the severity and duration of the defeat episodes. In a related study, Vidal et al (2011) found that better coping strategies might make Sprague Dawley rats more resilient to social defeat stress than Wistar rats as measured in fear-and anxiety-based domains 31 . Strain-dependent responses to other physical stressors such as restraint or CMS have been shown, underscoring the role of complex genetics in regulating risk and resilience to chronic stress [32][33][34] .…”

Section: Definition Of Resilience In Animalsmentioning

confidence: 99%

The Neurobiology of Resilience

Feder¹,

Horn²,

Haglund³

et al. 2017

Oxford Medicine Online

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Humans exhibit a remarkable degree of resilience in the face of extreme stress, with most resisting the development of neuropsychiatric disorders. Over the past 5 years, there has been increasing interest in the active, adaptive coping mechanisms of resilience; however, in humans, the majority of published work focuses on correlative neuroendocrine markers that are associated with a resilient phenotype. In this review, we highlight a growing literature in rodents that is starting to complement the human work by identifying the active behavioral, neural, molecular, and hormonal basis of resilience. The therapeutic implications of these findings are important and can pave the way for an innovative new approach to drug development for a range of stress-related syndromes.

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Male Wistar rats are more susceptible to lasting social anxiety than Wild-type Groningen rats following social defeat stress during adolescence

Cited by 43 publications

References 31 publications

Extended Effect of Chronic Social Defeat Stress in Childhood on Behaviors in Adulthood

Extended Effect of Chronic Social Defeat Stress in Childhood on Behaviors in Adulthood

Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes

The Neurobiology of Resilience

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