2013
DOI: 10.1128/jcm.01505-13
|View full text |Cite
|
Sign up to set email alerts
|

Male-Specific W4P/R Mutation in the Pre-S1 Region of Hepatitis B Virus, Increasing the Risk of Progression of Liver Diseases in Chronic Patients

Abstract: bThe issue of hepatitis B virus (HBV) mutations possibly leading to a gender disparity in the progression of liver diseases has not been explored. We aimed to elucidate the relationships of the novel pre-S1 mutations, W4P/R, with the progression of liver diseases and male predominance in a South Korean chronic cohort by use of a molecular epidemiologic study. We developed a fluorescence resonance energy transfer (FRET)-based real-time PCR (RT-PCR) assay for the detection of the W4P/R mutations and applied it t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

2
24
0

Year Published

2014
2014
2020
2020

Publication Types

Select...
6
1

Relationship

3
4

Authors

Journals

citations
Cited by 34 publications
(26 citation statements)
references
References 41 publications
2
24
0
Order By: Relevance
“…Finally, it should be mentioned, it was demonstrated previously that the point mutation W4P in the preS1 gene was restricted only in male patients ).…”
Section: Discussionmentioning
confidence: 83%
“…Finally, it should be mentioned, it was demonstrated previously that the point mutation W4P in the preS1 gene was restricted only in male patients ).…”
Section: Discussionmentioning
confidence: 83%
“…Finally, there is currently a shortage of experimental treatments on these issues, and empirical evidence for sex‐specific evolution of parasites is limited (but see Lee et al ., ). Experimental evolution approaches (see Masri et al ., , on a related topic) may provide opportunities to demonstrate these differences, as they allow to separate evolution of a parasite in one of the sexes or even to control the sex ratio of the host population.…”
Section: Discussionmentioning
confidence: 99%
“…It would be worthwhile to test these hypotheses in experimental populations, for instance by manipulating intrinsic survival through limiting reproduction, increasing resource availability or otherwise artificially manipulating the intrinsic mortality in one sex. Finally, there is currently a shortage of experimental treatments on these issues, and empirical evidence for sex-specific evolution of parasites is limited (but see Lee et al, 2013). Experimental evolution approaches (see Masri et al, 2013, on a related topic) may provide opportunities to demonstrate these differences, as they allow to separate evolution of a parasite in one of the sexes or even to control the sex ratio of the host population.…”
Section: Perspectivesmentioning
confidence: 99%
“…Moreover, an extraordinary prevalence of genotype C2 was reported in this area [3] . This genotype is more virulent than genotype B [4] , and it may contribute to the distribution of characteristic HBV mutation patterns that are related to the progression of liver diseases [5][6][7][8][9][10][11][12][13][14][15] . HBV surface open reading frames (ORFs) encode 3 types of proteins that share C terminals, large (L), middle (M), and small (S) surface antigen.…”
Section: Introductionmentioning
confidence: 99%