Male factor subfertility: possible causes and the impact of nutritional factors

Wong, Wai Yee; Thomas, Chris M.G.; Merkus, J.M.W.M.; Zielhuis, Gerhard A.; Steegers‐Theunissen, R.P.M.

doi:10.1016/s0015-0282(99)00551-8

Cited by 187 publications

(130 citation statements)

References 82 publications

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“…4,5 Although exact possible causes are not yet understood clearly, interactions between genetic and environmental factors have been suggested to be implicated with deteriorated semen quality. 6,7 Damage to the genetic component of spermatozoa have a crucial role in a majority of cases where current investigations fail to detect the specific cause of male infertility. 8 It has been shown that some genetic polymorphisms are associated with impaired spermatogenesis in infertile men with idiopathic oligoasthenoteratozoospermia.…”

Section: Introductionmentioning

confidence: 99%

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

2010

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The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not been well elucidated. A casecontrol study was performed to investigate the association between functionally important polymorphisms in GST genes and idiopathic male infertility. The study group consisted of 166 men suffering from idiopathic oligoasthenoteratozoospermia (OAT) and an equal number of age-matched healthy fertile male controls. Genomic DNA extracted from the peripheral blood, was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Multivariate regression analysis showed an increase in risk to infertility in the patients with null genotype of GSTM1 (OR: 2.18; 95% CI: 1.64-3.32; P¼0.001) or GSTT1 (OR: 1.88; 95% CI:1.12-2.52; P¼0.04). Our data further showed that combination of deletion genotypes of GST (GSTM1 and GSTT1) pose an even higher risk of infertility. In addition, GSTP1 wild-type genotype in combination with GSTM1 null or GSTT1 null genotype increased probability for infertility (OR: 2.47, 95% CI: 1.46-4.17: and OR: 2.69, 95% CI: 1.39-5.32, respectively). Similarly a much higher risk for infertility was noted in the patients carrying a genotype combination of GSTM1 null, GSTT1 null and GSTP1 (Ile/Ile) (OR: 4.45; 95% CI: 1.59-12.24; P¼0.002). The variant genotypes of GSTP1 (Ile/Val and Val/Val) resulted in a significant decreased risk to infertility in the cases (OR: 0.44; 95% CI: 0.29-0.78, P¼0.004). These results support the hypothesis of increased risk of GSTM1 or GSTT1null genotypes for developing infertility, but the nondeletion GSTM1 and GSTT1genotypes emerged as protective factors.

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Section: Introductionmentioning

confidence: 99%

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

2010

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“…It has been also suggested that the reproductive disorders in CD patients are a consequence of nutritional deficiencies caused by malabsorption (Rostami et al 2001). Abnormal ovarian development, obstatical disorders such as spontaneous abortion and still birth (Bougle & Proust 1999), male subfertility (Wong et al 2000) have been associated with zinc, selenium, iron, and folate deficiencies, often diagnosed in CD patients. The only proven treatment for coeliac disease is strict and life-long adherence to a gluten-free diet.…”

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confidence: 99%

Effect of buckwheat flour on microelements and proteins contents in gluten-free bread

Krupa‐Kozak¹,

Wronkowska²,

Soral‐Śmietana³

2011

Czech J. Food Sci.

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Krupa-Kozak U., Wronkowska M., Soral-Śmietana M. (2011): Effect of buckwheat flour on microelements and proteins contents in gluten-free bread. Czech J. Food Sci., 29: 103-108.Coeliac disease is an autoimmune gluten-sensitive entheropathy. The only available treatment for it is the life-long adherence to a gluten-free diet although these products are often poor in proteins, minerals, and vitamins. The current study was designed to investigate the effect of buckwheat flour incorporation to a gluten-free experimental formulation on the size-related parameters, and microelements and proteins contents. Buckwheat flour affected positively the technological quality of bread, like bread specific volume index and loaf size. Increasing concentration of buckwheat flour (10-40%) in bread affected the proportional enrichment in proteins and microelements, especially in copper and manganese.

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“…Elevated production of ROS by morphologically abnormal spermatozoa and/or reduction of antioxidant capacity of seminal plasma are possible causes of DNA damage in these patients [Agarwal et al 2004;Moskovtsev et al 2007]. Antioxidants added as dietary supplements have been shown to remove free radicals and reduce the degree of oxidative damage by improving the cellular redox equilibrium [Wong et al 2000]. The benefits of antioxidant therapy in male infertility are inconclusive with both a positive effect [Greco et al 2005;Menezo et al 2007] and no significant effect reported [Silver et al 2005].…”

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confidence: 99%

Cause-Specific Treatment in Patients with High Sperm DNA Damage Resulted in Significant DNA Improvement

Moskovtsev

Lecker²,

Mullen

et al. 2009

Systems Biology in Reproductive Medicine

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Assessment of sperm DNA damage has been suggested as a negative predictor of fertility potential. Multiple pathological factors acting at both the intratesticular and post-testicular levels may contribute to sperm DNA damage. The relative contribution of each of these factors in an individual with high DNA damage (430%) is unclear. The management of patients with elevated DNA damage is also challenging. The purpose of our retrospective study was to evaluate the clinical course of patients with sperm DNA damage over 30% and to assess the effect of non-specific (oral antioxidant) and cause-specific treatments on the quality of their sperm DNA. Results of our retrospective study suggest that the evaluated group with high DNA damage was diagnostically heterogeneous and comprised patients with varicoceles, bacteriospermia and idiopathic infertility. A three month course of antioxidant therapy reduced sperm DNA damage in only 30/61 (49%) patients with significant improvement between the initial and post-treatment DNA Fragmentation Index (DFI) results (46.8% AE 14.1 vs. 36.7% AE 16.6, p < .001). The positive effect of antioxidants could be age-dependent, as patients older that 40 years of age showed no improvement after such treatment. The cause-specific treatments showed superior results compared to antioxidants alone. Improvement was observed in 7/9 (78%) of patients after surgical varicocele repair between the initial and post-treatment DFI results (44.7% AE 12.8 vs. 28.4% AE 9.5, p < .03). The majority of the patients 13/14 (93%) with bacteriospermia had improvement in sperm DFI results after antibiotic treatment (50.4% AE 19.1 vs. 38.6% AE 18.7, p < .001).

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Male factor subfertility: possible causes and the impact of nutritional factors

Cited by 187 publications

References 82 publications

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

The association of glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility

Effect of buckwheat flour on microelements and proteins contents in gluten-free bread

Cause-Specific Treatment in Patients with High Sperm DNA Damage Resulted in Significant DNA Improvement

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