Male contraception: Past, present and future

Herdiman, J; Nakash, A.; Beedham, Trevor

doi:10.1080/01443610600955602

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…8,[36][37][38][39][40][41][42][43] The purpose of this review was to summarize the published data regarding hormone-based male contraceptive treatment options.…”

Section: Hormonal Treatmentmentioning

confidence: 99%

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

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Traditionally, male contraception has consisted of either barrier methods, such as condoms, or vasectomy. However, in recent years, we have made great strides in the basic science and clinical medicine to better understand the feedback mechanisms and physiology of the male reproductive system. These advances have enabled the development of several nonsurgical, hormonal, reversible, well-tolerated alternatives for male contraception. Men are more likely now than ever to participate in the choice of contraceptive techniques. This review will discuss the current status and recent developments in nonsurgical hormonal male contraception, a field that has been historically limited by social, financial and physiological challenges.

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“…8,[36][37][38][39][40][41][42][43] The purpose of this review was to summarize the published data regarding hormone-based male contraceptive treatment options.…”

Section: Hormonal Treatmentmentioning

confidence: 99%

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

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“…Although efforts to develop effective plant-derived male contraceptive agents have been undertaken, the progress in this area has been minimal. For instance, daily use of Tripterygium wilfordii extract elicited antifertility properties in animals and men by distorting sperm development and lowering sperm count but its use was associated with adverse side effects (Qian 1987;Herdiman et al 2006;D'Cruz et al 2010;Jing et al 2017). Furthermore, gossypol obtained from cotton seed oil provoked antifertility effects in human and animal models through reduction in sperm quality and increase in sperm mortality, degeneration of the testis and disruption of spermatogenesis and steroidogenesis (Coutinho 2002;Santana et al 2015;Lim et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Dietary fluted pumpkin seeds induce reversible oligospermia and androgen insufficiency in adult rats

Njoku

Uwakwe

Mgbudom-Okah

et al. 2019

Systems Biology in Reproductive Medicine

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Some components of the human diets are believed to be promising male contraceptive agents. The present study examined the antispermatogenic efficacy, reversibility and toxicity of fluted pumpkin seed-supplemented diet (DFPS) in adult male Wistar rats. Adult rats were given DFPS at 2.5, 5 and 10% for 60 days followed by 60 days post-treatment period. The control animals received normal standard rat diet not supplemented with fluted pumpkin seeds. The sperm quality variables, testosterone and follicle-stimulating hormone (FSH), oxidative status of the testis, steroidogenic enzymes and gamma-glutamyl transferase (γ-GT) activities and the histology of the testis were determined to evaluate the anti-fertility activity of fluted pumpkin seeds. Treatment of animals with DFPS at 5% and 10% resulted in decreased serum and intratesticular testosterone and FSH concentrations. This effect was associated with decreased activity of 17β-hydroxysteroid dehydrogenase (17β-HSD), increased testicular oxidative stress and poor sperm quality in the 10% diet group. After 60 days DFPS post-treatment, intra-testicular 17β-HSD and γ-GT activities, FSH and testosterone levels recovered to control values. Furthermore, poor sperm motility, count, morphology and viability as well as severe loss of spermatogonia and other matured epithelial germ cells and Sertoli cells observed especially in the 10% DFPS-treated animals reverted to nearly control values 60 days after withdrawal of treatment. Dietary fluted pumpkin seeds may selectively act on the epithelial germ cells, possibly mediated via Sertoli cells, leading to oligospermia, oxidative damage and androgen insufficiency. The reversibility of these effects to near normal levels after withdrawal of treatment justifies further consideration of DFPS as it may be an effective and readily reversible agent that meets the required criteria of a male contraceptive agent.

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