“…Most MSM are likely to be infected through a receptive rather an insertive role, which would further dilute the effects of MC in this population. In a Cochrane review by Wiysonge et al, including 21 observational studies (6 cohort, 14 cross-sectional, 1 case-control; 71,693 participants) were analyzed to assess the impact of circumcision for preventing HIV infection in MSM males the risk for HIV acquisition was not associated with MC (OR 0.86, 95% CI 0.7-1.06) [76]. In a subgroup analysis of men reporting an insertive role, MC was found to be protective (3465 participants; OR 0.27, 95% CI 0.17-0.44).…”