Male Breast Cancer: Presenting as Synchronous, Large, Bilateral Masses

Abstract

IntRoduCtIonMale breast cancer is a rare neoplasm which accounts for 1.2 -2 % of all cancers in men and 1% of the total cases of breast cancer [1,2]. The incidence of bilateral breast cancer accounts for only 0.5 -1 % of male breast cancers and synchronous cancers are extremely rare [3,4]. Carcinoma of the male breast has many similarities with the breast cancer which occurs in women [5]. We are reporting this case for rarity of the disease, advanced presentation of the lesion and synchronous bilateral breast cancer.

Synchronous Male Breast Cancer and a Review of the Literature

“…No other risk factors for male breast cancer were present. These risk factors include radiation exposure, endocrine abnormalities, obesity or testicular disorders (cryptochidism, Mumps orchitis, orchiectomy) or Klinefelter's syndrome [2][3][4][5][6][7][8]. the 12-1 o'clock position, 1 cm from the nipple.…”

“…Male breast cancer is uncommon, occurring in less than 1% of all cases of breast cancer [1][2][3][4][5][6][7][8]. Synchronous bilateral breast cancer is rare and less common than metachronous bilateral breast cancer [1,[3][4][5][6][7][8][9]. In a cohort of 2524 male breast cancer patients diagnosed between 1988 and 2008, the incidence of synchronous male breast cancer was estimated to be 2.1%, while 2.3% were metachronus [9].…”

“…In a cohort of 123,757 female breast cancer patients diagnosed between 1970 and 2000, the incidence of synchronous female breast cancer was estimated to be 1.6%, while 3.8% were metachronous [10]. Most cases of male breast cancer are detected between the age of 60 to 70, and the mean age is 67 years [1,[3][4][5][6][7][8]. Due to lack of routine breast cancer screening, most male breast cancers are diagnosed at a later stage (Stage II in men versus Stage I in women) and therefore conferring a lower survival rate [11].…”

Bilateral, Synchronous Breast Carcinoma in Monozygotic Male Twins with Multi-system Developmental Anomalies: Proposition of a Congenital Etiology

“…Male breast cancer accounts for less than one percent of all breast cancer cases with ductal carcinoma in situ (DCIS) accounting for just 5% of male breast cancer cases (1)(2)(3)(4). Furthermore, bilateral male breast cancer accounts for less than 0.02% of all breast cancer cases (1).…”

“…Male breast cancer accounts for approximately 1% of all cancers in males (2). While there are only scant reports in the literature describing bilateral, synchronous male breast carcinoma (1-6), none have been reported in monozygotic twins.…”