Male breast cancer: a report of 127 cases at a Moroccan institution

Abstract

BackgroundMale breast cancer (MBC) is a rare disease representing less than 1% of all malignancies in men and only 1% of all incident breast cancers. Our study details clinico-pathological features, treatments and prognostic factors in a large Moroccan cohort.FindingsOne hundred and twenty-seven patients were collected from 1985 to 2007 at the National Institute of Oncology in Rabat, Morocco.Median age was 62 years and median time for consultation 28 months. The main clinical complaint was a mass beneath the areola in 93, 5% of the cases. Most patients have an advanced disease. Ninety-one percent of tumors were ductal carcinomas.Management consisted especially of radical mastectomy; followed by adjuvant radiotherapy and hormonal therapy with or without chemotherapy. The median of follow-up was 30 months. The evolution has been characterized by local recurrence; in twenty two cases (17% of all patients). Metastasis occurred in 41 cases (32% of all patients). The site of metastasis was the bone in twenty cases; lung in twelve cases; liver in seven case; liver and skin in one case and pleura and skin in one case.ConclusionMale breast cancer has many similarities to breast cancer in women, but there are distinct features that should be appreciated. Future research for better understanding of this disease at national or international level are needed to improve the management and prognosis of male patients.

Clinicopathologic Characteristics of Male Breast Cancer: A Report of 21 Cases in Radiotherapy Center of Hamedan, Iran

“…we could not define any occupational specify in this study unless the history of breast cancer in 4 patients family history (Cutuli et al, 2010;Bourthafour and Belbarake, 2011).…”

“…Given its low incidence, few studies have assessed risk and prognosis The literature about male breast cancer consists of retrospective studies and there are no randomized prospective data so the therapy is based on standards admitted from female breast cancer. Data obtained from retrospective analysis demonstrate that male breast cancer is not exactly the same disease as female breast cancer and notable differences have emerged (Bourthafour et al, 2011). Men tend to be diagnosed at an older age and higher estrogen receptor (ER) and progesterone receptor (PR) expression is notable in men.…”

Breast Cancer in Morocco: A Literature Review

“…Worldwide men breast cancer is uncommon and represents less than 1% of all cancers registered (Cutuli et al, 2010 (Bourhafour et al, 2011). Clinical and treatment characteristics of male breast cancer seems to have many similarities with women breast cancer but still have more aggressive behavior .As suggested by El Youbi et al (2013) no study to date has concerned the assessment of the psycho-social impact of this disease on the Moroccan patient and his family.…”

The Management and Outcomes of Male Breast Cancer

“…Databases show that up to 93% of MBC cases are of advanced disease, and that distant metastases are observed in approximately 30% of these patients at the time of diagnosis (19,46). In the current study, the most frequent involvements were bone (n=12, 70.6%), lung (n=6, 35.3%), cranial field (n=3, 17.6%), brain (n=2, 11.8%), liver (n=2, 11.8%), pleura (n=1, 5.9%), and mesentery (n=1, 5.9%).…”

“…MBC usually presents as a painless subareolar lump that is usually identified by palpation (17)(18)(19)(20). Pain is associated with the lump in only 5% of cases (21).…”