Malaysian herbal monograph development and challenges

Tan, Terence Yew Chin; Muhammad, Hussin; Yusof, Norsyaidatul Akmal Mohd; Teh, Bee Ping; Mohamed, Ami Fazlin Syed

doi:10.1016/j.hermed.2020.100380

Cited by 19 publications

(12 citation statements)

References 9 publications

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“…The use of dual authentication methods (DNA barcoding and HPLC) for bigger datasets of 257 samples from the Brazilian market revealed a high level of substitution (71%) [41]. The present study showed that chemical methods cannot distinguish species that have similar chemical markers, possibly misidentifying the sources of raw materials, consistent with the findings from other researchers [3,52]. In summary, the present work showed the establishment of molecular analysis and chemical fingerprinting methods for discriminating Labisia herbal medicinal products.…”

Section: Hplc Fingerprinting Of L Pumila Hmpssupporting

confidence: 88%

“…As the herbal industry continues to experience growth, quality control must be done. The monograph has been published as a referral standardized operating document for the sourcing of raw material, analytical testing techniques, and safety information [3]. Herbal medicinal products come in various forms, commonly in processed or modified forms (dried material, tablets, powders, capsules, or tablets), thereby presenting a challenge in accurately distinguishing genuine products from fake ones [4].…”

Section: Introductionmentioning

confidence: 99%

“…Even though no serious adverse effects of Labisia herbal medicinal products for consumption have been reported so far, development of authentication methods is crucial to ensure their safety and efficacy. Various Malaysian government bodies have worked together to develop comprehensive monographs containing specifications for profiling techniques for raw material sourcing until approval [3]. Additionally, the Forest Research Institute Malaysia (FRIM) laboratory provides testing services and acts as an advisor to HMP manufacturers [17].…”

Section: Introductionmentioning

confidence: 99%

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Integrated Approach for Species Identification and Quality Analysis for Labisia pumila Using DNA Barcoding and HPLC

Tarmizi

Wagiran

Salleh

et al. 2021

Plants

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Labisia pumila is a precious herb in Southeast Asia that is traditionally used as a health supplement and has been extensively commercialized due to its claimed therapeutic properties in boosting a healthy female reproductive system. Indigenous people used these plants by boiling the leaves; however, in recent years it has been marketed as powdered or capsuled products. Accordingly, accuracy in determination of the authenticity of these modern herbal products has faced great challenges. Lack of authenticity is a public health risk because incorrectly used herbal species can cause adverse effects. Hence, any measures that may aid product authentication would be beneficial. Given the widespread use of Labisia herbal products, the current study focuses on authenticity testing via an integral approach of DNA barcoding and qualitative analysis using HPLC. This study successfully generated DNA reference barcodes (ITS2 and rbcL) for L.pumila var. alata and pumila. The DNA barcode that was generated was then used to identify species of Labisia pumila in herbal medicinal products, while HPLC was utilized to determine their quality. The findings through the synergistic approach (DNA barcode and HPLC) implemented in this study indicate the importance of both methods in providing the strong evidence required for the identification of true species and to examine the authenticity of such herbal medicinal products.

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Section: Hplc Fingerprinting Of L Pumila Hmpssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Integrated Approach for Species Identification and Quality Analysis for Labisia pumila Using DNA Barcoding and HPLC

Tarmizi

Wagiran

Salleh

et al. 2021

Plants

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“…The Malaysian rainforest is not only acknowledged as the world's oldest rainforest but also ranked 12th in the world as well as 4th on the list of biodiversity hotspots in Asia after India, China, and Indonesia. Malaysia has an estimated 12,500 species of seed plants with about 1200 species of medicinal plants [1]. Malaysia is also endowed with more than 3000 species of medicinal plants among its over 15,000 flowering plants [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Herbal products, as a general health supplement, also offer self-empowerment, self-reassurance, and other psychological benefits during lactation, in addition to other general ailments such as colds, constipation, coughs, headaches, and depressive symptoms [5,8]. Admittedly, the lack of standardization and heterogeneity of regulatory standards for herbal products between, and within countries and regions have made it quite difficult to generalize about the quality, efficacy, and safety of herbal products [1,8]. Nevertheless, this study is aimed to review some of the most important high-value herbal products in Malaysia.…”

Section: Introductionmentioning

confidence: 99%

Ethnomedicinal Uses of Some Common Malaysian Medicinal Plants

Ahmed¹

2022

Natural Drugs From Plants

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Historically, natural products have always been a rich source of novel pharmacological leads, thus, making the ethnobotanical and ethnopharmacological knowledge an important and major asset of the medicinal plant-based drug discovery in providing hints for effective and safe chemotherapeutic compounds. Such knowledge, however, requires a thorough review and documentation of the ethnomedicinal and indigenous uses of local plants of every part of the world. Malaysia is a global hub for natural products which contributes to its GDP. Malaysia is also one of the 12 most diverse Megabiodiversity countries. Its rainforest is ranked 4th on the list of biodiversity hotspots in Asia after India, China, and Indonesia and is also acknowledged as the world’s oldest rainforest. Natural products are relevant to both Malaysian health care and agriculture which are parts of the national key economic areas (NKEA) under the Government’s Economic Transformation Plan as well as parts of the United Nations’ 17 Sustainable Development Goals (SDGs). Though the quality, efficacy, and safety of herbal products require global and international standardization, herbal products should be made accessible to low-income and rural communities across the globe. The proper documentation of the ethnopharmacological important plants in addition to their preservation and cultivation would enhance the sustainable use of the various indigenous plants. This work is unique in the sense that it is meant to review some of the most important high-value herbal products in Malaysia. Though it covers only a few representatives of Malaysian medicinal plants.

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