Malathion and fenvalerate induce micronuclei in mouse bone marrow cells

Abstract

Health effects of pesticides are a major public health concern. In this study, the genotoxic effects of two commonly-used pesticides, malathion, and fenvalerate, were investigated in mice in vivo. Induction of micronuclei in bone marrow cells was used as the test parameter following exposure to 2.5, 5 or 10 mg/kg malathion by intraperitoneal (i.p.) or per oral (p.o.) exposure. Exposure by both routes was found to cause a significant increase in micronucleated polychromatic erythrocytes (PCEs) in a dose-dependent manner (r = 0.9769; P < 0.05). The highest dose (10 mg/kg) induced significant (P < 0.05) cytotoxicity. In contrast, fenvalerate caused an increase in micronucleated PCEs only at higher doses (10 and 20 mg/kg) via i.p. injection, and was not associated with cytotoxicity. A significant dose-response correlation was not observed in the dose ranges tested for fenvalerate (r = 0.8704; P > 0.05). The results suggest that technical grade malathion is a genotoxic agent. In contrast, technical grade fenvalerate appears to be a potent genotoxic agent, but this observation should be confirmed with further investigation(s).

Altered canonical hedgehog-gli signalling axis in pesticide-induced bone marrow aplasia mouse model

“…Previous studies have affi rmed the genotoxic and/or cytotoxic effects of Type II pyrethroids such as cyfl uthrin, cypermethrin etc. (4)(5)(6)(7)(8)(9). The carcinogenic potential of pyrethroids was also reported on the murine model (9).…”

Carcinogenicidade e mutagenicidade do malathion e seus dois análogos: uma revisão sistemática

“…Swiss albino mice strains exposed to malathion evidenced bone marrow cell metaphases with various types of chromosomal alterations, and the pesticide-induced significantly higher frequency of alterations (p<0.001) in the three acute doses tested (2.5, 5 and 10mg/ kg) than in control, besides increased frequencies of sister chromatid exchanges and sperm head anomalies 59 . Giri et al 54 reported the dose-dependent increased frequency of micronucleated polychromatic erythrocytes in bone marrow cells of mice of the same species after in vivo exposure to malathion at 95% purity.…”