Malarial risk factor identification in southern Minahasa, North Celebes Manado-Indonesia

Pinontoan, Odi R.; Punuh, Maureen I.

doi:10.15562/bmj.v6i2.659

Cited by 2 publications

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“…Bed nets are considered to be a traditional means of prevention, and it has been proven that they are useful for avoiding mosquito bites. Thus, it is obvious that our research findings are consistent with other research findings in both Indonesia [13,14] and in African countries [15,16]. The local health authority in Banjarnegara distributes impregnated bed nets for free to all households to protect at-risk groups such as pregnant women and children under five years of age.…”

Section: Discussionsupporting

confidence: 90%

Malaria Risk Factors in Banjarnegara, Indonesia: A Matched Case-Control Study

Sulistyawati

Rokhmayanti

Fatmawati

2020

J UOEH

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Malaria is a matter of concern in public health worldwide. Identifying its risk factors is essential to determine control efforts. We studied the potential environmental and human behaviour risk factors in malaria by a matched case-control study conducted in the Banjarmangu I Public Health Centre area, Banjarnegara, from June to August 2018. A structured questionnaire and checklist were employed to collect data from 50 participants. Data were analysed by Chi-Square, Fisher exact and logistic regression. A positive association was found between malaria and not sleeping under bed mosquito netting (OR=2.087 [95% CI: 1.148-3.795]), not using wire netting in the house ventilation (OR = 3.907 [95% CI: 0.647-24.452]), and inadequate prevention practices during outdoor activities (OR = 2.020 [95% CI: 1.033-3.953]). These three factors were identified as independent risk factors for malaria.

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Section: Discussionsupporting

confidence: 90%

Malaria Risk Factors in Banjarnegara, Indonesia: A Matched Case-Control Study

Sulistyawati

Rokhmayanti

Fatmawati

2020

J UOEH

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“…Routine malaria reports reveal a roughly 30% increase in malaria cases in Indonesia, rising from 304,607 cases in 2021 to 400,253 cases in 2022. Of these, the highest number of cases occurred in Papua Province, accounting for 356,889 cases (90%) of the national total [3][4][5]. Despite reports of partial resistance to Artemisinin Combination Therapy (ACT) in Southeast Asia [6][7][8] and East Africa [9,10], artemisinin-based therapies have remained the foundation of malaria management for over two decades.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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Background: Malaria poses a substantial threat to healthcare systems across the globe. The escalating resistance of malaria parasites to the absence of affordable and accessible antimalarial medications has exacerbated the challenges associated with malaria treatment. This research aims to evaluate the antimalarial and antioxidant properties of Stichopus hermanni in combination with artemisinin, employing murine malaria models. Method: This study employed the 4-day suppression test procedure and conducted an experimental investigation with a post-test-only control group design. The study involved 35 male BALB/c mice, aged 7-10 weeks, each infected with Plasmodium berghei ANKA/PbA. The sample was divided into five groups: C1 (negative control), C2 (positive control), T1 (administered 15 mg/Kg BW/day of Stichopus hermanni ethanol extract and 0.04 mg/g BW/day of artemisinin), T2 (administered 17 mg/Kg BW/day of Stichopus hermanni ethanol extract and 0.04 mg/g BW/day of artemisinin), and T3 (administered 20 mg/Kg BW/day of Stichopus hermanni ethanol extract and 0.04 mg/g BW/day of artemisinin). The parameters measured included % parasitemia level, % growth inhibition, and malondialdehyde (MDA) levels. Results: The T3 group exhibited the lowest parasitemia level and the highest degree of growth inhibition compared to the other groups (p-value < 0.05). However, statistically, it did not differ significantly from C2 and T1. Meanwhile, the T3 group demonstrated the lowest MDA levels and the most significant antioxidant capacity compared to the other groups (pvalue < 0.05). Conclusion: Based on both descriptive and statistical analyses, the combination of Stichopus hermanni ethanol extract and artemisinin exhibits antimalarial and antioxidant activities.

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Malarial risk factor identification in southern Minahasa, North Celebes Manado-Indonesia

Cited by 2 publications

References 0 publications

Malaria Risk Factors in Banjarnegara, Indonesia: A Matched Case-Control Study

Malaria Risk Factors in Banjarnegara, Indonesia: A Matched Case-Control Study

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