Malaria Therapy and Prophylaxis with Cotrifazid, a Multiple Complex Combination Consisting of Rifampicin + Isoniazid + Sulfamethoxazole + Trimethoprim

Abstract

This report contains the first therapeutic results with the multiple combination rifampicin + isoniazid + sulfamethoxazole + trimethoprim in the treatment of malaria. Clinical symptoms declined rapidly and parasites were cleared from the erythrocytes. Tolerance was excellent. This fixed combination is outstandingly practicable, with few problems with compliance.

Treatment of Malaria tropica with a Fixed Combination of Rifampicin, Co-Trimoxazole and Isoniazid: A Clinical Study

“…The reasons for use of CF in the treatment of malaria tropica was based exclusively on empiric data reported in 1995/1996 [5,6]. These investigators reported previously for CF positive therapeutic results in tuberculosis, leprosy and chronic Salmonella sp.…”

“…These investigators reported previously for CF positive therapeutic results in tuberculosis, leprosy and chronic Salmonella sp. carriers [6]; they postulated a 'synergism' between CF components [19] and stressed the need for a fixed combination, particularly for low-income countries [5,6].…”

“…The fixed combination of rifampicin, cotrimoxazole and isoniazid (CF, Cotrifazid TM ) was reported [5,6] to be effective in the treatment of malaria tropica, even in cases of apparent drug resistance of the P. falciparum to conventional antimalarials. It is the aim of this study to scrutinize these findings from Malawi under the conditions of a hyperendemic Kenyan region.…”

Cotrifazid – An Agent against Malaria

“…The clinical picture improves quickly [7], In a few days, the erythrocytes become com pletely negative (free of parasites; tables 2-4).…”

“…In the context of this wide-ranging research program utilizing the experience with other disease (leprosy, tuberculosis, leishmaniasis, salmonellosis), Cotrifazid in the following combination (table l) [6] was used in Malawi [7] in nonpretreated Plasmodium falciparum cases (malaria tropica) and in cases pretreated in vain with Fansidar, quinine or chloroquine.…”