Malaria parasitemia and its association with lipid and hematological parameters among malaria-infected patients attending at Metema Hospital, Northwest Ethiopia

Sirak, Solomon; Fola, Abebe A.; Worku, Ligabaw

doi:10.2147/plmi.s118946

Cited by 23 publications

(31 citation statements)

References 31 publications

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“…Median values for Hemoglobin and Platelet count were significantly lower for the malaria group compared with the controls (18). As well as data obtained from study in Thailand-Myanmar border, it concerned about platelet count which found low among infected children by 31.8 times (19), indicating agreement with our finding as platelet count was low than healthy subjects count with significant difference and also the same finding data in Ethiopian study targeted Plasmodium falciparum infected subjects (20).…”

Section: Discussionsupporting

confidence: 91%

Determination of Hematological Parameters and D-Dimer Among Sudanese Children Infected With Plasmodium Falciparum in Khartoum State – Sudan.

Abdallah

Elnager²,

Wdidi³

et al. 2019

IJMBS

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Background: Falciparum malaria is one of the causes of morbidity and mortality in third world , the pathogenesis of the infection results from the sequestration of infected hematological change in vital organs. Aim: this study aim to measuring hematological changes and D- dimer among children affected with P falciparum. Methods: The total study group100 children, 60 as case study infected with Plasmodium Falciparum and 40 as control group healthy children. Hematological parameter measuring by hematological analyzer and D dimer measured by fluorescence Immunoassay used I. Chroma instrument. Results: Statistical analysis results of sixty children infected with malaria falciparum participated in the study the mean±SD had a significantly lower Hb (8.14gm/dl ± 2.2) and haematocrit (24.4% ± 6.6) than control children (p <0.001), Thrombocytopenia was found in 59.3% of enrolled patients. Platelet count (98.53% ± 48.9) , D. dimer (7397.58 ng/ml ± 5867.07) (p <0.001). D. dimer showed correlation with parasite density, Platelet count and Haematocrit correlated (r = 0.4, p <0.0001); (p <0.001). Conclusion: Malaria infection by plasmodium falciparum had major effects on hematological parameters such as thrombocytopenia , anemia and hyper coagulation have been significantly associated with severity of malaria falciparum. Keywords: Plasmodiu, Falciparum, D-dimer, Hematological parameters

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Section: Discussionsupporting

confidence: 91%

Determination of Hematological Parameters and D-Dimer Among Sudanese Children Infected With Plasmodium Falciparum in Khartoum State – Sudan.

Abdallah

Elnager²,

Wdidi³

et al. 2019

IJMBS

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“…Hgb and Hct showed statistically significant decrement in malaria patients in concordance with study conducted in Metema, Ethiopia (22). But MCHC were statistically significant increment in contrast to study conducted in Thailand-Myanmar border (34) and Metema, Ethiopia (22).…”

Section: Comparisons Of Hematological Parameters Among Cases and Contsupporting

confidence: 77%

“…Thrombocytopenia is also a typical characteristic of malaria, especially with PV malaria (19). Other hematological changes include neutropenia, eosinophilia, neutrophilia and monocytosis were commonly observed in studies conducted in different parts of the world (20), Africa (21) and Ethiopia (22). So, determination of the hematological changes enables the clinician to establish an effective and early therapeutic intervention in order to prevent the occurrence of major complications in those malaria patients.…”

Section: Pathophysiology Of Malaria On Hematological Parameters Changmentioning

confidence: 99%

“…Comparative cross sectional study design was used in this study. Sample size was calculated by using a double population proportion formula for comparison of two populations mean obtained from previously conducted study in Metema, Ethiopia by the year 2016 (29). Accordingly, a total of 238 (119 malaria positive and 119 screened blood donor) participants were included in the study.…”

Section: Study Population Design Sample Size Determination and Sampmentioning

confidence: 99%

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Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Asmerom

Yalew

Getaneh

2019

Preprint

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Background: Hematological changes are the most common complications encountered in malaria and they play a major role in malaria pathology. Hematological changes like red blood cells, platelets and leukocytes have been observed in patients with malaria. Therefore, this study aimed to compare hematological parameters of malaria infected adult patients in Alamata Hospital, Northeast Ethiopia from February 01- April 30, 2019. Methods: Comparative cross sectional study was used to compare the hematological parameters on a total of 238 study participants, consisting of 119 malaria infected patients and 119 malaria negative controls at Raya Alamata Hospital. Malaria diagnosis was done based on thick and thin blood films microscopy. Hematological parameters were determined by using an automated, DiRUi BCC/3000B hematology analyzer. Malaria parasite density was determined by counting the asexual parasites against 200 WBCs, and then calculated by using the standard formula. Data for the different hematological parameters were expressed as mean (±SD). Independent t-test was used for comparison the hematological parameters between the two groups. Binary logistic regression model was constructed for categorical dependent variables to see associations between predictors and outcomes. Results: In current study parameters like red blood cells count, hemoglobin, mean corpuscular volume, platelets count, and eosinophil counts were significantly lowered in malaria-infected patients than the controls. The prevalence of anemia and thrombocytopenia in malaria patients was 39.5% and 56.3%, respectively. Being female and malaria parasitaemia were found significantly associated with thrombocytopenia. The odds of developing thrombocytopenia with high malaria parasitaemia were 8.4 times more likely develop thrombocytopenia.Conclusion: Anemia and thrombocytopenia were the two common hematological abnormalities seen in malaria patients. The platelet count during malaria infection was inversely correlated with the parasitaemia. Malaria patients should be checked for the presence of hematological abnormalities such as anemia and have to be managed for those abnormalities. Keywords: Malaria, Malaria parasitaemia, Hematological parameters, Ethiopia

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“…22,24,25 A systematic review and meta-analysis in agreement with our study reported that TC, HDL and LDL concentrations were lower in P. falciparum malaria patients as compared to healthy controls (p ˂0.05). 26 The decline was more pronounced and statistically significant during malaria compared to other febrile diseases but TG and VLDL levels showed no significant difference compared to healthy controls (p ˃0.05).…”

Section: Exclusion Criteriamentioning

confidence: 83%

Study of serum lipid profile in Plasmodium falciparum malaria

2018

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Background: Malaria is a major public health problem in India with wide-ranging haematological and biochemical alterations. Plasmodium falciparum (P. falciparum) is one of four distinct species of the malaria parasite that afflict humans and pose a threat to public health. Under normal physiological conditions, liver ensures homeostasis of lipid and lipoprotein metabolism. Therefore, the aim of this study was to assess malaria infection and its association with lipid parameters changes. Hepatocellular damage often associated with severe and acute P. falciparum infections impairs these processes, leading to alteration in plasma lipid profile and lipoprotein patterns. An observation on the nature of dyslipidaemia in confirmed cases of P. falciparum malaria patients with reference to correlation if any that exists between malaria and lipid profile in these patients was performed.Methods: A case-control study was carried out on clinically and laboratory confirmed P. falciparum malaria positive patients attending the outpatient and inpatient department of RIMS Ranchi for a period of six months i.e. from January 2018 to June 2018, 100 participants were enrolled for the present study. 50 participants were P. falciparum malaria confirmed cases and 50 participants were without any clinical or laboratory evidence of malaria served as the control.Results: It revealed that the total cholesterol, HDL and LDL were significantly decreased -(P ≤0.05) while triglyceride and VLDL were not significantly changed in P. falciparum malaria patients (P ≥0.05).Conclusions: It can be concluded that alteration in lipid profile can be an index of severe malaria infection that may leads to poor prognosis, but specificity of malaria infection with lipid changes is questionable and need further studies.

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Malaria parasitemia and its association with lipid and hematological parameters among malaria-infected patients attending at Metema Hospital, Northwest Ethiopia

Cited by 23 publications

References 31 publications

Determination of Hematological Parameters and D-Dimer Among Sudanese Children Infected With Plasmodium Falciparum in Khartoum State – Sudan.

Determination of Hematological Parameters and D-Dimer Among Sudanese Children Infected With Plasmodium Falciparum in Khartoum State – Sudan.

Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Study of serum lipid profile in Plasmodium falciparum malaria

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