Malakoplakia of the Larynx

Malakoplakia of Larynx: A Case Report and Literature Review of Localized Malakoplakia of Larynx

“…The neoplasms in all cases with a single tumor, including our case, were found in the supraglottic region. In the two cases with multiple tumors, in addition to the supraglottic region, lesions were also found in the trachea 16 and vocal cords 17 respectively. The malakoplakia is usually associated with gram-negative bacilli infection 18 , and is common in immunocompromised patients.…”

“…Among them, the malakoplakia of three cases occurred in the vallecula, [12][13][14] one case in the epiglottis, 15 three cases in the false vocal cord (including this case). 16,17 This case report is combined with a literature review (Table 1).…”

Malakoplakia of the Neck

“…One other case of malakoplakia occurring within the cervical soft tissues has been reported, 1 while there have been several cases in which malakoplakia has developed in extracervical areas of the head and neck (middle ear, n=2; nasopharynx, n = 1; tonsil, n = 3; tongue, n=2; larynx, n=4; and trachea, n=1). [2][3][4][5] In all cases, the clinical presentations were characteristic of an underlying malignancy, in particular epidermoid carcinoma or lymphoma. As malakoplakia can mimic a neoplastic process, it may also be associated with other chronic inflammatory conditions, such as Whipple disease, Ché diak-Steinbrinck-Higashi syndrome, tuberculosis, sarcoidosis, and immunodeficiency.…”

Malacoplakia of the Vallecula Masquerading as a Malignancy

“…Th e histologic hallmark of the disease is the presence of large granular macrophages (von Hansemann cells) that contain laminated, calcifi ed structures (Michaelis-Gutmann bodies). 2,3 However, microscopic features may be variable, and typical von Hansemann cells and Michaelis-Gutmann bodies are not always conspicuous. Smith postulated that the lesions of malacoplakia evolve through three histologic phases: (1) an early prediagnostic phase, which is characterized by the presence of an infi ltrate of plasma cells, von Hansemann macrophages, and eosinophils and an absence of Michaelis-Gutmann bodies; (2) a classic phase, which is characterized by the presence of sheets of large macrophages that contain Michaelis-Gutmann bodies along with lymphocytes and plasma cells; and (3) a fi brosing phase, which is characterized by islands of macrophages with Michaelis-Gutmann bodies set in a fi brous stroma.…”