Malakoplakia in the Gastrointestinal Tract of a Liver Transplant Recipient

Rull, R.; Grande, Laura; Jc, García-Valdecasas; Ja, Bombí; Alós, L.; Fuster, Josep; Am, Lacy; Cugat, Esteban; Fx, González; Rimola, A.

doi:10.1097/00007890-199505270-00026

Cited by 13 publications

(8 citation statements)

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“…The process is most commonly found in the urogenital tract, and is histiologically characterized by tumorlike masses consisting of aggregates of characteristic histiocytes, known as Von Hasemann histiocytes. 1 Within these histiocytes are the hallmark "targetlike" structures-basophilic, periodic acid-Schiff (PAS)-positive, diastase-resistant and von Kossa-positive calcospherules, known as Michaelis-Gutmann bodies-which are found both intra-and extracellularly. 2 The calcospherules are remnants of defective phagolysosomes in macrophages that are unable to completely degrade bacteria and eventually become mineralized by calcium phosphate crystals.…”

mentioning

confidence: 99%

Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Teeters

Betts

Ryan

et al. 2007

The Journal of Heart and Lung Transplantation

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mentioning

confidence: 99%

Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Teeters

Betts

Ryan

et al. 2007

The Journal of Heart and Lung Transplantation

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“…Only four cases were previously reported in kidney transplant recipients from 1994 to 2010. Other transplant-associated colonic malakoplakia included three cases with liver transplants and one with a cardiac transplant 8,11-13. All patients in the reported cases presented some symptoms, including diarrhea, abdominal pain, fever, and intestinal perforation.…”

Section: Discussionmentioning

confidence: 93%

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

et al. 2013

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Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.

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“…4 The most commonly found bacterium is Escherichia coli , but Klebsiella , Proteus , Pseudomonas , Mycobacterium avium , Mycobacterium tuberculosis , Shigella , Staphylococcus aureus and Enterococcus spp were also found. 23,24 Rhodococcus equi is the most commonly implicated microbe in HIV-infected patients. 25 In 75% of cases, the disease affects the genitourinary tract, but other systems have been implicated, including the skin.…”

Section: Discussionmentioning

confidence: 99%