Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Teeters, John C.; Betts, Robert F.; Ryan, Charlotte; Huether, J.; Elias, K; Hartmann, Diane M.; Massey, Todd; Chen, L.

doi:10.1016/j.healun.2007.01.004

Cited by 13 publications

(20 citation statements)

References 8 publications

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“…Only four cases were previously reported in kidney transplant recipients from 1994 to 2010. Other transplant-associated colonic malakoplakia included three cases with liver transplants and one with a cardiac transplant 8,11-13. All patients in the reported cases presented some symptoms, including diarrhea, abdominal pain, fever, and intestinal perforation.…”

Section: Discussionmentioning

confidence: 94%

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

et al. 2013

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Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.

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Section: Discussionmentioning

confidence: 94%

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

et al. 2013

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“…15-17 Almost all transplanted patient cases refer to kidney recipients, as the one in this article, but two were reported in heart transplant recipients. 18,19 There are few reports in which prevalence among women is higher (2:1). 20,21 The age peak occurs between the sixth and seventh decades, being even rarer in children.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous malakoplakia: case report and review

Afonso

Ando

Padilha

et al. 2013

An. Bras. Dermatol.

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“…Malakoplakia is a chronic granulomatous reaction characterized by the accumulation of distinctive macrophages (von Hansemann's cells) containing pathognomonic intracytoplasmic calcific structures (Michaelis–Gutmann bodies) . The etiology of the disease is presumed to be infection, coupled with an inadequate host response, resulting in incomplete degradation of the bacteria and an unusual inflammatory response . Malakoplakia is a rare entity, most commonly found associated with systemic diseases such as systemic lupus erythematosus, tuberculosis, diabetes mellitus, sarcoidosis, and neoplasm, but may also be associated with steroid treatment and other immune‐suppressed states .…”

Section: Discussionmentioning

confidence: 99%

“…Since 1902, approximately 450 cases have been reported in the literature, with >75% involving the genitourinary tract and <10% involving the gastrointestinal tract . Malakoplakia appears to result from a functional deficiency of macrophages, resulting in an inability to destroy ingested bacteria . Most patients with this condition are immunosuppressed or have a chronic illness .…”

Section: Introductionmentioning

confidence: 99%

Endoscopic mucosal resection of a rectal malakoplakia in a healthy adult

Sato

Tsukamoto

Mizuno³

et al. 2013

Digestive Endoscopy

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Malakoplakia in the gastrointestinal tract is rare in healthy young people without underlying disease. Sufficient tissue is required for accurate diagnosis. We describe a malakoplakia that developed in a healthy young woman and was treated by endoscopic mucosal resection (EMR). A 40-year-old woman with a history of taking oral contraceptives until one year earlier was referred to our hospital with anal bleeding and constipation. A colonoscopy carried out at our another hospital 18 months earlier disclosed no abnormal findings. Colonoscopy at presentation revealed a yellowish-white tumor, 5 mm in diameter, in the rectum. The lesion was slightly protruded and had a smooth flat surface, without erosion or ulceration. EMR was carried out for a definitive diagnosis. Histopathological examination showed that the tumor contained granular histiocytes, positive for CD68 and negative forcytokeratin (AE1/AE3). Several histiocytes contained intracytoplasmic round bodies (Michaelis-Gutmann bodies), which reacted positively with periodic acid-Schiff and calcium (Von Kossa) stains. Intracytoplasmic Escherichia coli (von Hansemann bodies) were identified by Giemsa staining. Based on these results, the tumor in the rectum was diagnosed as a malakoplakia. Following EMR, the patient did not receive further treatment for malakoplakia because she had no symptoms associated with malakoplakia. She has been well for more than 9 months, with no symptoms of disease. Awareness of colorectal malakoplakia is important in patients taking steroids, including oral contraceptives.

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Rectal and Cutaneous Malakoplakia in an Orthotopic Cardiac Transplant Recipient

Cited by 13 publications

References 8 publications

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination

Cutaneous malakoplakia: case report and review

Endoscopic mucosal resection of a rectal malakoplakia in a healthy adult

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