Makerspace microfabrication of a stainless steel 3D microneedle electrode array (3D MEA) on a glass substrate for simultaneous optical and electrical probing of electrogenic cells

Morales-Carvajal, Paola M.; Kundu, Atreyee; Didier, Charles M.; Hart, Cacie; Sommerhage, Frank; Rajaraman, Swaminathan

doi:10.1039/d0ra06070d

Cited by 8 publications

(6 citation statements)

References 35 publications

(44 reference statements)

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“…(4) The microfabrication technology and materials of MEAs are being optimized to achieve a lower cost and faster preparation. In addition, the use of SU-8 to replace traditional SiO 2 and Si 3 N 4 insulation layers [64] and 3D printing technology to easily make MEAs (Figure 3D) [65] are pioneering attempts in this field.…”

Section: Development Direction Of In Vitro Measmentioning

confidence: 99%

Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and Microelectrode Arrays

Liu

Yang

et al. 2023

Micromachines

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Recent years have witnessed a spurt of progress in the application of the encoding and decoding of neural activities to drug screening, diseases diagnosis, and brain–computer interactions. To overcome the constraints of the complexity of the brain and the ethical considerations of in vivo research, neural chip platforms integrating microfluidic devices and microelectrode arrays have been raised, which can not only customize growth paths for neurons in vitro but also monitor and modulate the specialized neural networks grown on chips. Therefore, this article reviews the developmental history of chip platforms integrating microfluidic devices and microelectrode arrays. First, we review the design and application of advanced microelectrode arrays and microfluidic devices. After, we introduce the fabrication process of neural chip platforms. Finally, we highlight the recent progress on this type of chip platform as a research tool in the field of brain science and neuroscience, focusing on neuropharmacology, neurological diseases, and simplified brain models. This is a detailed and comprehensive review of neural chip platforms. This work aims to fulfill the following three goals: (1) summarize the latest design patterns and fabrication schemes of such platforms, providing a reference for the development of other new platforms; (2) generalize several important applications of chip platforms in the field of neurology, which will attract the attention of scientists in the field; and (3) propose the developmental direction of neural chip platforms integrating microfluidic devices and microelectrode arrays.

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Section: Development Direction Of In Vitro Measmentioning

confidence: 99%

Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and Microelectrode Arrays

Liu

Yang

et al. 2023

Micromachines

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“…In recent years, different types of MN-based biosensors including electrochemical, optical, magnetic, and paper-based have been studied in the literature [ 140 , 141 , 142 , 143 , 144 , 145 ]. Besides some exceptions, electrochemistry is the preferred approach in MN-based biosensor design owing to many notable properties, including inherent miniaturization, highly scalable fabrication, rapid, inexpensive, low-power consumption requirements, and easier deployment to MNs [ 36 , 146 , 147 , 148 , 149 , 150 ]. Various surface chemistry procedures and transduction modes can be combined and deployed into MN-based biosensors according to the selection of targeted biomolecule.…”

Section: Applications Of Mns In the Detection Of CD Biomarkersmentioning

confidence: 99%

Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases

et al. 2021

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Chronic diseases (CDs) are noncommunicable illnesses with long-term symptoms accounting for ~70% of all deaths worldwide. For the diagnosis and prognosis of CDs, accurate biomarker detection is essential. Currently, the detection of CD-associated biomarkers is employed through complex platforms with certain limitations in their applicability and performance. There is hence unmet need to present innovative strategies that are applicable to the point-of-care (PoC) settings, and also, provide the precise detection of biomarkers. On the other hand, especially at PoC settings, microneedle (MN) technology, which comprises micron-size needles arranged on a miniature patch, has risen as a revolutionary approach in biosensing strategies, opening novel horizons to improve the existing PoC devices. Various MN-based platforms have been manufactured for distinctive purposes employing several techniques and materials. The development of MN-based biosensors for real-time monitoring of CD-associated biomarkers has garnered huge attention in recent years. Herein, we summarize basic concepts of MNs, including microfabrication techniques, design parameters, and their mechanism of action as a biosensing platform for CD diagnosis. Moreover, recent advances in the use of MNs for CD diagnosis are introduced and finally relevant clinical trials carried out using MNs as biosensing devices are highlighted. This review aims to address the potential use of MNs in CD diagnosis.

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“…More detailing, main drawbacks in unlocking clinical implementation of MNs rely on the availability of low‐cost and rapid manufacturing methods. [ 14 ] As a general strategy, MNs can be fabricated using metals (e.g., stainless steel and titanium), [ 15 ] metalloids (e.g., silicon), [ 16 ] biodegradable polymers (polylactic acid and polyglycolic acid), [ 17 ] and non‐biodegradable polymers (e.g., polyvinyl acetate or polyetherimide). [ 18 ] Additive manufacturing techniques such as 3D printing and two‐photon polymerization processes are transformative methods in solid MN fabrication.…”

Section: Introductionmentioning

confidence: 99%

Xenon Difluoride Dry Etching for the Microfabrication of Solid Microneedles as a Potential Strategy in Transdermal Drug Delivery

Eş

Kafadenk

Gormus

et al. 2023

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Makerspace microfabrication of a stainless steel 3D microneedle electrode array (3D MEA) on a glass substrate for simultaneous optical and electrical probing of electrogenic cells

Abstract: Microfabrication and assembly of 3D MEA based on a glass-stainless steel platform is shown utilizing non-traditional “Makerspace Microfabrication” techniques featuring cost-effective, rapid fabrication and an assorted biocompatible material palette.

Cited by 8 publications

References 35 publications

Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and Microelectrode Arrays

Recent Progress and Perspectives on Neural Chip Platforms Integrating PDMS-Based Microfluidic Devices and Microelectrode Arrays

Recent Advances in Microneedle-Based Sensors for Sampling, Diagnosis and Monitoring of Chronic Diseases

Xenon Difluoride Dry Etching for the Microfabrication of Solid Microneedles as a Potential Strategy in Transdermal Drug Delivery

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