Xenon Difluoride Dry Etching for the Microfabrication of Solid Microneedles as a Potential Strategy in Transdermal Drug Delivery

Eş, Ismail; Kafadenk, Abdullah; Gormus, M. Burak; İnci, Fatih

doi:10.1002/smll.202206510

Cited by 8 publications

(1 citation statement)

References 58 publications

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“…Transdermal insulin delivery is a novel approach that circumvents the liver's first-pass effect to improve insulin bioavailability and enhance patient compliance. 3,4 Microneedle (MN) patches including solid, 5 hollow, 6 and soluble 7,8 MN types, are potential tools for transdermal drug delivery for effective delivery of insulin via the skin stratum corneum and epidermis for sustained release. Among them, soluble MNs have attracted significant interest due to their safe dissolution within skin tissues, facilitating insulin release and averting significant infection transmission.…”

Section: Introductionmentioning

confidence: 99%

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Ma,

Wang,

et al. 2024

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Ma,

Wang,

et al. 2024

Biomater. Sci.

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Soft and Flexible Bioelectronic Micro‐Systems for Electronically Controlled Drug Delivery

Mariello,

Eş,

Proctor

2023

Adv Healthcare Materials

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The concept of targeted and controlled drug delivery, which directs treatment to precise anatomical sites, offers benefits such as fewer side effects, reduced toxicity, optimized dosages, and quicker responses. However, challenges remain to engineer dependable systems and materials that can modulate host tissue interactions and overcome biological barriers. To stay aligned with advancements in healthcare and precision medicine, novel approaches and materials are imperative to improve effectiveness, biocompatibility, and tissue compliance. Electronically controlled drug delivery (ECDD) has recently emerged as a promising approach to calibrated drug delivery with spatial and temporal precision. This article covers recent breakthroughs in soft, flexible and adaptable bioelectronic micro‐systems designed for ECDD. It overviews the most widely reported operational modes, materials engineering strategies, electronic interfaces, and characterization techniques associated with ECDD systems. Further, it delves into the pivotal applications of ECDD in wearable, ingestible, and implantable medical devices. Finally, the discourse extends to future prospects and challenges for ECDD.This article is protected by copyright. All rights reserved

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Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

Haidari,

Bright,

et al. 2024

Small Science

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Microneedles (MNs) have emerged as a promising transdermal antimicrobial delivery system, providing precise and localized drug delivery while complemented with noninvasiveness and patient compliance. Currently, the topical application of antimicrobials restricts the delivery of drugs to the critical areas of the wound bed, largely due to barriers posed by the necrotic tissue, scab formation, and bacterial biofilms, which severely diminish the bioavailability of the therapeutics. MNs have enabled efficient and targeted delivery to overcome many chronic wound challenges. Over the past decade, significant progress has been made to develop MNs with unique properties tailored for the delivery of vaccines, anticancer, and antimicrobials. As ongoing research continues to refine MN design, material properties, and drug formulations, the potential for revolutionizing antimicrobial drug delivery for efficacy, patient experience, and therapeutic outcomes remains at the forefront of scientific research. In this review, insights are provided into the latest progress, current developments, and the diverse applications of MNs for antimicrobial drug delivery. Herein, the translational potential of MNs is highlighted and a perspective on the current challenges associated with clinical translation is provided. Furthermore, this review aids in identifying research gaps while empowering and contributing to the future implementation of cutting‐edge delivery systems to effectively tackle antimicrobial resistance.

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Xenon Difluoride Dry Etching for the Microfabrication of Solid Microneedles as a Potential Strategy in Transdermal Drug Delivery

Abstract: findings, augmenting the current literature of MNs. Overall, the optimized process provides a wide range of solid MN types that would be utilized for either epidermis or dermis targeting to current transdermal drug delivery studies.

Cited by 8 publications

References 58 publications

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Soft and Flexible Bioelectronic Micro‐Systems for Electronically Controlled Drug Delivery

Development of Microneedles for Antimicrobial Drug Delivery: A Comprehensive Review on Applications in Wound Infection Management

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