Major Histocompatibility Complex Class 1 Chain-Related Antigen A Antibodies: Sensitizing Events and Impact on Renal Graft Outcomes

Lemy, Anne; Andrien, Marc; Wissing, Karl Martin; Ryhahi, Khadija; Vandersarren, Aurélie; Racapé, Judith; Heylen, Christine; Ghisdal, Lidia; Broeders, Emine Nilufer; Vereerstraeten, Pierre; Toungouz, Michel; Abramowicz, Daniel

doi:10.1097/tp.0b013e3181e228f7

Cited by 48 publications

(49 citation statements)

References 20 publications

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“…It has been suggested that pregnancy can induce MICA antibodies [20]. By contrast, the role of blood transfusions in the induction of MICA antibodies is unclear [23,29]. However, the effect of MICA mismatching in organ transplantation has not been fully addressed, largely because of a paucity of information on donor and recipient MICA types.…”

Section: Introductionmentioning

confidence: 88%

Major histocompatibility complex class I–related chain A allele mismatching, antibodies, and rejection in renal transplantation

et al. 2011

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Section: Introductionmentioning

confidence: 88%

Major histocompatibility complex class I–related chain A allele mismatching, antibodies, and rejection in renal transplantation

et al. 2011

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“…Identification of serum IgG MICA Abs was performed using Luminex beads bound to single recombinant MICA antigens (Gen-Probe Transplant Diagnostics), as described previously (14). HLA class I and II antibody screening was performed according to the manufacturer's instructions using Luminex beads coated with HLA class I and HLA class II antigens (Gen-Probe Transplant Diagnostics), providing either a positive or negative result.…”

Section: Anti-mica and Anti-hla Antibody Detectionmentioning

confidence: 99%

“…In solid organ recipients (8)(9)(10)(11) and dialysis patients (12), the overall rate of seroconversion to the seasonal flu vaccine is in the range of 30% to 50%. The use of adjuvanted vaccine has raised concerns for immunocompromised patients, because of possible induction of allo-immune responses, such as anti-human histocompatibility leukocyte antigen (HLA) antibodies (Abs) or MHC class I-related chain A (MICA) Abs (13)(14)(15)(16). Indeed, the AS03 adjuvant present in some vaccines promotes immunogenicity by modulating the expression of local cytokines and by increasing the antigen loading in monocytes (17).…”

Section: Introductionmentioning

confidence: 99%

Influenza A/H1N1 Vaccine in Patients Treated by Kidney Transplant or Dialysis

Broeders

Hombrouck²,

Lemy³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives In 2009, the pandemic influenza A/H1N1 accounted for worldwide recommendations about vaccination. There are few data concerning the immunogenicity or the security of the adjuvanted-A/H1N1 vaccine in transplanted and hemodialyzed patients.Design, setting, participants, & measurements Sera from 21 controls, 53 hemodialyzed (HD) patients, and 111 renal transplant recipients (RT) were sampled before (T0) and 1 month after (T1) a single dose of Pandemrix® vaccine (GSK Biologicals, AS03-adjuvanted). We measured the neutralizing antibodies against A/H1N1/2009, the geometric mean (GM) titers, the GM titer ratios (T1/T0) with 95% confidence intervals, and the seroconversion rate (responders: Ն4-fold increase in titer). The HLA and MICA immunization was determined by Luminex technology. ResultsThe GM titer ratio was 38 (19 to 78), 9 (5 to 16), and 5 (3 to 6) for controls, HD patients, and RT patients, respectively (P Ͻ 0.001). The proportion of responders was 90%, 57%, and 44%, respectively (P Ͻ 0.001). In RT patients, the prevalence of histocompatibility leukocyte antigen (HLA) class I, histocompatibility leukocyte antigen class II, and MHC class I-related chain A immunization, was, respectively, 15%, 14%, and 14% before and 14%, 14%, and 11% after vaccination (P ϭ 1, 1, and 0.39). ConclusionsThe influenza A/H1N1-adjuvanted vaccine is of limited efficacy but is safe in renal disease populations. The humoral response is lower in transplanted versus hemodialyzed patients. Further studies are needed to improve the efficacy of vaccination in those populations.

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“…8 Zou and associates 2 reported that antibodies against MICA alleles were detected in 217 of 1910 patients (11.4%) before transplant. The presence of MICA antibodies has been associated with renal allograft rejection.…”

Section: Discussionmentioning

confidence: 99%

Detection of Antibodies Against Major Histocompatibility Complex Class I-Related Chain A in Long-term Renal Graft Recipients

Luo²,

Qiu³

et al. 2012

Exp Clin Transplant

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Objectives: To determine the prevalence, allele specificity, and intensity of anti-MICA antibodies in long-term renal graft recipients and to investigate their association with impaired renal function. Materials and Methods: Sixty-eight long-term (> 10 y) renal graft recipients were divided into 2 groups: (1) patients with impaired renal function (serum creatinine ≥ 2 mg/dL, n=6); (2) patients with normal renal function (serum creatinine < 176.8 µmol/L, n=62). Anti-MICA antibodies were tested using Luminex single antigen beads assays and the frequency, specificity, and intensity of these antibodies were compared between 2 patient groups. Results: MICA antibodies were detected in 33% of impaired renal function patients and 15% of normal renal function patients (P > .05). Anti-MICA*027 antibodies were found in 11.76% of patients, whereas antibody to MICA*012 was found in 2.94% of patients. Interestingly, among all antibody specificities, MICA*001,*004, *007, *009, *012, and *018 were found more frequently in impaired renal function patients than in normal renal function patients. The peak mean fluorescence intensity levels of MICA antibodies in impaired renal function patients were significantly higher than those in normal renal function patients (P < .05). Conclusions: Our data suggest that increased prevalence and intensity of anti-MICA antibodies are associated with impaired renal graft function in long-term renal graft recipients and some MICA antibodies might be more important than others in mediating graft rejection.

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Major Histocompatibility Complex Class 1 Chain-Related Antigen A Antibodies: Sensitizing Events and Impact on Renal Graft Outcomes

Abstract: In summary, (1) sensitizing events for MICA Abs are the same as for human leukocyte antigen Abs; (2) MICA Abs did not adversely affect renal graft outcomes in our cohort.

Cited by 48 publications

References 20 publications

Major histocompatibility complex class I–related chain A allele mismatching, antibodies, and rejection in renal transplantation

Major histocompatibility complex class I–related chain A allele mismatching, antibodies, and rejection in renal transplantation

Influenza A/H1N1 Vaccine in Patients Treated by Kidney Transplant or Dialysis

Detection of Antibodies Against Major Histocompatibility Complex Class I-Related Chain A in Long-term Renal Graft Recipients

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