Detection of Antibodies Against Major Histocompatibility Complex Class I-Related Chain A in Long-term Renal Graft Recipients

Li, Zuowei; Luo, Ming; Qiu, Jianxin; Liu, Yong; Fan, Yu; Jahr, Fay M.; Cai, Junchao; Terasaki, Paul I.

doi:10.6002/ect.2011.0103

Cited by 10 publications

(7 citation statements)

References 12 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Li et al. did not find any significant differences in MICA antibodies between patients with impaired kidney function and normal renal function over 10 yr. Further analysis showed that the level of MICA antibodies in long‐term renal graft cases were remarkably lower than in patients with normal renal function, suggesting that MICA antibodies are involved in graft rejection.…”

Section: Mica In Renal Transplantationmentioning

confidence: 92%

Role of MICA antibodies in solid organ transplantation

Luo

et al. 2013

Clinical Transplantation

View full text Add to dashboard Cite

As a potential transplant antigen, major histocompatibility complex class I chain-related gene A (MICA) antigen, has attracted increased attention because of its possible role in solid organ transplantation. There are two MICA forms, and MICA antibodies and soluble MICA (sMICA) have been found in the serum of transplant recipients. We searched MEDLINE, EMBASE, and the Cochrane Library for original reports of clinical studies involving the effect of MICA on outcomes of renal, heart, lung, and liver transplantation. In addition to the human leukocyte antigen antigens, which elicit a strong immune response, the polymorphic MICA antigens induce production of MICA antibodies and sMICA. A number of clinical studies have shown that MICA antibodies correlate with an increased incidence of rejection and a decreased allograft survival rate following renal or heart transplantation. Although it is clearly associated with chronic rejection of lung allografts, no such correlation was found for liver transplantation. Moreover, sMICA showed a negative association with acute rejection (AR) and may be a good predictor of heart transplant outcomes. These data suggest MICA expression patterns and regulatory function may be tissue specific and that different transplants have different organ-specific outcomes.

show abstract

Section: Mica In Renal Transplantationmentioning

confidence: 92%

Role of MICA antibodies in solid organ transplantation

Luo

et al. 2013

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…According to Zou Y. et al MICA antigens are significantly associated with and might play a role in rejection, in the absence of previous sensitization against HLA, like in recipients of first transplants, patients who received grafts from well-HLA-matched donors and recipients not previously sensitized against HLA. The role of anti-HLA and anti-MICA antibodies in graft failure was confirmed in several studies [66][67][68]. However, Lemy A. at al.…”

Section: The Role Of Anti-mica Antibodies In Kidney Transplantationmentioning

confidence: 97%

MICA Polymorphism, Association with Diseases and the Role of Anti-MICA Antibodies in Organ and Stem Cell Transplantation

Kirijas

Спироски

2013

Maced J Med Sci

View full text Add to dashboard Cite

Major histocompatibility complex class 1 chain-related genes (MIC) are part of the non-classical MHC genes located on the short arm of chromosome 6. MICA comprises of approximately 11 kb DNA and encodes polypeptide of 383 amino acids. The expression of MICA is limited to the surface of the epithelial cells, fibroblasts, keratinocytes and monocytes, but not on the surface of CD4+, CD8+ and CD19+ lymphocytes. It manifests its role by binding with the NK cell receptor NKG2D. There are 84 different alleles for MICA due to discovered polymorphisms in the exons 2 to 5. The aim of this review is to present the data known so far about the association of MICA with different diseases and the role of anti-MICA antibodies in organ and stem cell transplantation. The frequency of different MICA alleles and their association with different HLA-B alleles, as well as the association of MICA with different inflammatory diseases, infection diseases and tumors was determined. Post-and pre-transplant anti-MICA antibodies are associated with antibody-mediated rejection in kidney and heart transplantation. Patients with hematopoietic stem cell transplantation, which have MICA mismatch, have higher frequency of graft versus host disease episodes. In spite of lack of conclusive data about the role of anti-MICA antibodies in organ and stem cell transplantation, there is still clinical relevance for investigation of the polymorphisms of the MICA gene and anti-MICA antibodies.

show abstract

“…In renal , lung , heart and liver transplantation, recent reports identified posttransplantation MICA antibody development as a risk factor for allograft rejection. In HSCT these alloantibodies are described as an independent risk factor for development of acute and chronic GVHD (graft vs host disease) .…”

Section: Introductionmentioning

confidence: 99%

Methodological and clinical aspects of alloimmunization after granulocyte transfusion in patients undergoing allogeneic stem cell transplantation

et al. 2014

View full text Add to dashboard Cite

In allogeneic hematopoietic stem cell transplantation (HSCT), granulocyte transfusions (GT) may be required in immunocompromised, neutropenic patients. In this context, alloimmunization against alloantigens may occur and affect HSCT outcome. Anti-human leukocyte antigen (HLA) and -MHC class I chain related antigens A (MICA) antibody response after the administration of GT in 29 patients undergoing allogeneic HSCT (n = 27) encompassing 109 sera was investigated by multianalyte microbead assay before and up to 6 month after HSCT. Anti-HLA class I and II antibodies emerged de novo in 11 (38%) and 4 (14%) patients, respectively. Similarly, preformed antibodies were observed in four cases (14%) for anti-HLA class I and also four patients for anti-HLA class II antibodies. Anti-MICA antibodies were observed in eight granulocyte recipients of which three patients developed anti-MICA antibodies after GT, whereas preformed antibodies were seen in five patients. The conversion to positivity for any of the investigated antibodies did not significantly affect overall survival or the incidence of GVHD. GT-associated alloantibody conversion observed did not significantly correlate with outcome. Thus, surveillance of anti-HLA antibodies in the course of GT in the context of HSCT may not be required routinely. The role of MICA antibodies in HSCT and GT, however, requires further study.

show abstract

Detection of Antibodies Against Major Histocompatibility Complex Class I-Related Chain A in Long-term Renal Graft Recipients

Cited by 10 publications

References 12 publications

Role of MICA antibodies in solid organ transplantation

Role of MICA antibodies in solid organ transplantation

MICA Polymorphism, Association with Diseases and the Role of Anti-MICA Antibodies in Organ and Stem Cell Transplantation

Methodological and clinical aspects of alloimmunization after granulocyte transfusion in patients undergoing allogeneic stem cell transplantation

Contact Info

Product

Resources

About