Major histocompatibility complex and strong human leukocyte antigen–DRB1 and gender association with Vogt–Koyanagi–Harada syndrome in Mexican Mestizos

Aláez, C.; Flores-A, Hilario; Concha-del-Río, Luz Elena; Munguia, Andrea; Rodríguez, Araceli; García, David; Arellanes, Lourdes; Gorodezky, Clara

doi:10.1016/j.humimm.2011.09.002

Cited by 17 publications

(17 citation statements)

References 44 publications

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“…After reviewing the full text, 11 studies were excluded because they had overlapping information in cases and/or controls with another publications1415161718192021222324, and 4 were excluded because they investigated other variants but not HLA-DR4/ HLA-DRB1*04 25262728, two were excluded because there was no control2930. Eventually, 21 studies6910313233343536373839404142434445464748 were retained that contributed data to association of VKH and HLA-DR4/ HLA-DRB1*04 . There were 19 articles in English, 2 in Chinese.…”

Section: Resultsmentioning

confidence: 99%

Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis

Shi

Zhang

et al. 2014

Sci Rep

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Human leukocyte antigen (HLA)-DR4/HLA-DRB1*04 has been reported to be a risk factor for Vogt-Koyanagi-Harada disease (VKH) with various strength of association. Its sub-alleles were also found to be associated with VKH. However the results were inconsistent. In this study, we systematically searched the related literature, pooled the odds ratios (ORs) and 95% confidence interval (CI) of association of HLA-DR4/HLA-DRB1*04 or its sub-alleles with VKH from individual studies, and explored the potential source of heterogeneity. A total of 1853 VKH patients and 4164 controls from 21 articles were included in this meta-analysis. The pooled OR of association of HLA-DR4/HLA-DRB1*04 and VKH was 8.42 (95% CI: 5.69–12.45). There were significant heterogeneity (I2 = 71%). Subgroup analysis indicated that ethnicity was the source of heterogeneity (all I2 = 0, ORs ranged from 2.09–13.69 in subgroups). The sub-alleles, HLA-DRB1*0404 (OR = 2.57), 0405 (OR = 10.31) and 0410 (OR = 6.52) increased the risk of VKH; 0401 (OR = 0.21) protected VKH; while other sub-alleles were not associated with VKH. Our meta-analysis confirmed the association between VKH and HLA-DR4/DRB1*04, found the strength of association is different in different ethnic groups, and identified HLA-DRB1*0404, 0405 and 0410 as risk sub-alleles while 0401 as protective sub-allele.

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Section: Resultsmentioning

confidence: 99%

Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis

Shi

Zhang

et al. 2014

Sci Rep

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“…99 A sex stratification analysis among Mexican Mestizo healthy individuals and VKH patients showed that DRB1*04:05 and DRB1*04:04 were significantly increased in VKH patients and that these alleles were associated with female sex only. 100 No significant sex difference in VKH prevalence was reported in Asian populations. 101,102 …”

Section: Non-infectous Uveitidesmentioning

confidence: 99%

Gender Disparities in Ocular Inflammatory Disorders*

Sen

Davis

Uçar

et al. 2014

Current Eye Research

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Ocular inflammatory disorders disproportionately affect women, and the majority of affected women are of childbearing age. The role of sex or reproductive hormones has been proposed in many other inflammatory or autoimmune disorders, and findings from non-ocular autoimmune diseases suggest a complex interaction between sex hormones, genetic factors and the immune system. However, despite the age and sex bias, factors that influence this disparity are complicated and unclear. This review aims to evaluate the gender disparities in prevalence, incidence and severity of the most common infectious and non-infectious ocular inflammatory disorders.

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“…52 The reason for the poorer male visual outcomes is unclear, though female sex hormones and HLA-DR genes have been associated with the female predisposition to the disease. 50, 53-55 …”

Section: Female Predominant Uveitides With Systemic Involvementmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

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Uveitides can be due to non-infectious and infectious etiologies. It has been observed that there is a gender difference with a greater preponderance of non-infectious uveitis in women than in men. This review will describe both non-infectious and infectious uveitides and describes some of the current autoimmune mechanisms thought to be underlying the gender difference. It will specifically look at non-infectious uveitides with systemic involvement including juvenile idiopathic arthritis, spondyloarthopathies, sarcoidosis, Behçet’s disease, and Vogt-Koyanagi-Harada disease and at uveitides without systemic involvement including sympathetic ophthalmia, birdshot chorioretinitis, and the white dot syndromes. Infectious uveitides like acute retinal necrosis, progressive outer retinal necrosis, and cytomegalovirus mediated uveitis will be mentioned. Different uveitides with female- or male- predominance are presented and discussed.

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Major histocompatibility complex and strong human leukocyte antigen–DRB1 and gender association with Vogt–Koyanagi–Harada syndrome in Mexican Mestizos

Cited by 17 publications

References 44 publications

Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis

Association of HLA-DR4/HLA-DRB1*04 with Vogt-Koyanagi-Harada disease: A Systematic Review and Meta-analysis

Gender Disparities in Ocular Inflammatory Disorders*

The Role of Sex in Uveitis and Ocular Inflammation

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