Major grass pollen allergens and components detected in a southern Chinese cohort of patients with allergic rhinitis and/or asthma

Luo, Wenting; Huang, Huayi; Zheng, Peiyan; Wei, Nili; Luo, Jiaying; Sun, Baoqing; Zeng, Guangqiao

doi:10.1016/j.molimm.2016.08.013

Cited by 33 publications

(28 citation statements)

References 26 publications

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“…In either province, male subjects had significantly higher overall prevalence of sensitization than females ( X 2 = 14.751, P < 0.001 X 2 = 9.323, P < 0.05). We stratified the study population by age to account for the subjects in different life stages as described in previous studies 13 , 17 : infancy (years 0–3): 291 in Guangdong and 186 in Yunnan), preschool age (years 4–6: 223 in Guangdong and 170 in Yunnan), older children (years 7–14: 224 in Guangdong and 293 in Yunnan), young adulthood (years 15–50: 549 in Guangdong and 629 in Yunnan) and late adulthood (years 51 and above: 60 in Guangdong and 153 in Yunnan). When stratified by age, allergen sensitization showed interesting differences among age groups in both Guangdong and Yunnan ( X 2 = 85.824, P < 0.001; X 2 = 10.401, P < 0.05).…”

Section: Resultsmentioning

confidence: 99%

A cross-sectional observational study on allergen-specific IgE positivity in a southeast coastal versus a southwest inland region of China

Zeng

Luo

et al. 2017

Sci Rep

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Few studies addressed trans-regional differences in allergen sensitization between areas within a similar latitudinal range but with distinct geomorphological features. We investigated specific IgE (sIgE) positivity to common allergens in populations from two southern China provinces. Using a uniformed protocol, serum samples were collected from 2778 subjects with suspected atopy in coastal Guangdong and inland Yunnan. The overall prevalence of sIgE positivity were 57.8% (95% CI: 56.0%, 59.6%) from Guangdong vs 60.9% (95% CI: 59.1%, 62.7%) from Yunnan. House dust mite (d1) was the most common allergen in both regions. Among d1-sensitized subjects, only 35.7% (208/583) in Guangdong and 22.9% (147/642) in Yunnan tested positive for d1 alone. Among those poly-sensitized d1-positive subjects, cockroach was the most common co-sensitizing aeroallergen. 41.9% of the d1-sensitized Guangdong subjects showed high-class sIgE reactivity (≥class 4), in contrast to a very low percentage of such reactivity in Yunnan. However, 36.3% of d1-sensitized subjects in Yunnan were concomitantly positive for tree pollen mix. Surprisingly, Yunnan subjects showed high prevalence of sIgE positivity for crabs and shrimps, either by overall or by age-group analysis, compared with their Guangdong counterparts (both P < 0.05). These findings may add to data about local allergies in China and worldwide.

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Section: Resultsmentioning

confidence: 99%

A cross-sectional observational study on allergen-specific IgE positivity in a southeast coastal versus a southwest inland region of China

Zeng

Luo

et al. 2017

Sci Rep

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“…13 Regarding CCD and plant allergens, Sinson et al has reported that the CCDpositive rate in patients sensitized to Timothy grass was 16.7% 14 and our previous study found that 41.4% of patients with positive sIgE results of Bermuda grass also showed CCD-sIgE positive. 5 In this study, most of the components used in the EuroBlot tests were recombinant molecules, which provided good markers for the diagnosis of sensitization to components. Because certain purified allergen components were glycosylated and it may cause false positive result due to CCD reactivity.…”

Section: Discussionmentioning

confidence: 93%

“…3,4 Our previous research found that more than 60% of Bermuda grass sensitized rhinitis/asthma patients were sensitized to Timothy grass, while another study showed that some Bermuda grass sensitized patients were also co-sensitized to Mugwort. 5 It is likely that these allergens might contain the same protein components inducing cross-reactive. Alternatively, it could be due to the cross-reactive carbohydrate determinants (CCD), a substance that led to positive detection results without causing any allergic symptoms, which was found in a large number of plant allergens.…”

Section: Introductionmentioning

confidence: 99%

<p>Major Pollen Allergen Components and CCD Detection in Bermuda Grass Sensitized Patients in Guangzhou, China</p>

Liao¹,

Liang²,

Hu³

et al. 2020

JAA

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“…In China, a vast East-Asian territory, regional specificity of grass pollen sensitization is further complicated by limited data currently available from the southern part of this country over the past decades 5 . Such a paucity in data has led to a difficulty in showing the overall grass pollen sensitization in this large country 6 .…”

Section: Introductionmentioning

confidence: 99%

“…This work describes a method used to test serum sIgE reactivity to Bermuda grass, Timothy grass, and Humulus scandens in patients from Greater Guangzhou (southern China's largest city and its outskirts) with allergic rhinitis and/or asthma using the CRD approach 5 . These findings on sensitization to these subtropical and temperate grass pollens in southern China add important evidence to that currently in the literature.…”

Section: Introductionmentioning

confidence: 99%

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Luo

Pan

Huang

et al. 2017

JoVE

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Sensitization to grass pollen imposes a global risk for allergic airway diseases. Although prevention relies on local investigation of the pollen allergens, data on this topic are limited in southern China. Any available data were obtained by self-report questionnaires, skin prick tests, and total or specific IgE tests using crude extracts. For many reasons, these methods are unreliable. Serum sIgE reactivity to Bermuda grass, Timothy grass, and Humulus scandens allergens in a cohort of patients from Greater Guangzhou (southern China's largest city and its outskirts) with allergic rhinitis and/or asthma were examined using a fully-automated immunoassay analyzer as a component-resolved diagnostics (CRD) tool. For the first time, a considerably high prevalence of Bermuda grass sIgE positivity was demonstrated in Chinese southerners with allergic rhinitis and/or asthma. In these patients, a subtle prevalence of sensitization to Timothy grass and Humulus scandens was also noted, which may arise from cross-reactivity, as the latter two are not common in the region. This was also supported by the detection of allergen components. Fully-automated immunoassay analyzers may offer satisfactory consistency between regions, laboratories, and institutions and over time. The automaticity of the instrument may enable a standardized detection that would not have been readily revealed before the advent of CRD. This is a study that uses a CRD approach to investigate sensitization to grass pollen allergens in southern China. It adds to current evidence in the literature. Future studies are needed to validate these findings. However, although CRD is a useful tool, the findings made with the fully-automated immunoassay analyzer should not substitute for other laboratory investigations, clinical evaluations, and physician expertise.

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Major grass pollen allergens and components detected in a southern Chinese cohort of patients with allergic rhinitis and/or asthma

Cited by 33 publications

References 26 publications

A cross-sectional observational study on allergen-specific IgE positivity in a southeast coastal versus a southwest inland region of China

A cross-sectional observational study on allergen-specific IgE positivity in a southeast coastal versus a southwest inland region of China

<p>Major Pollen Allergen Components and CCD Detection in Bermuda Grass Sensitized Patients in Guangzhou, China</p>

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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