&lt;p&gt;Major Pollen Allergen Components and CCD Detection in Bermuda Grass Sensitized Patients in Guangzhou, China&lt;/p&gt;

Liao, Chenxi; Liang, Cuiying; Hu, Haisheng; Luo, Wenting; Wu, Ge; Huang, Zhifeng; Wu, Liting; Sun, Baoqing

doi:10.2147/jaa.s277704

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…Allergen components from different species may have the same functions. 30 The sensitization of highly cross-reactive allergens (such as profilin, calcium-binding protein or cross-reactive carbohydrate determinants) in distant relatives may be the reason for the common sensitization of different allergens. Martin Canis pointed out that trees and grasses are structurally similar allergens that can be classified as taxonomic allergens, and patients with a representative allergy (such as birch and timothy) may also respond to other sources of this class (such as hazelnut and rye).…”

Section: Discussionmentioning

confidence: 99%

A Multicenter Study Assessing Risk Factors and Aeroallergens Sensitization Characteristics in Children with Self-Reported Allergic Rhinitis in China

Wu¹,

Luo²,

Hu³

et al. 2021

JAA

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Background: Up to now, epidemiological studies on allergy rhinitis (AR) have primarily focused on determining the risk of disease in Chinese adults, with the majority of them designed by single centers, while cross-sectional and epidemiological data describing allergic sensitization in children with self-reported AR are scarce. Objective: This study was estimating of the latest information about the sensitization patterns and risk factors of clinical AR to develop effective strategies for the prevention and treatment of AR. Methods: We conducted a cross-sectional survey between January 2020 and June 2021 involving children from seven cities in China who reported AR. A total of 762 children participated in this survey. To evaluate the risk factors and specific sensitization patterns of clinical AR through questionnaires and specific immunoglobulin E to 11 aeroallergens. Results: Of the 762 patients, 593 (77.8%) had at least one positive IgE level. Aged 7-14 years (OR 1.503, (95% CI 1.058-2.136), P = 0.023); With allergic conjunctivitis (OR 1.843, (95% CI 1.297-2.620), P = 0.001) and living in the Eastern (OR 1.802, (95% CI 1.263-2.573), P = 0.001) all elevated the risk of clinical AR associated with aeroallergens. The sensitization rates of D. pteronyssinus and D. farinae were higher than those of other allergens in the 0-6 and 7-14 years old age groups. The most common aeroallergens among self-reported children with AR in the eastern were D. farinae (74.9%) and D. pteronyssinus (74.3%), while in the western were mugwort (60.0%) and marguerite (56.6%). Majority of sIgE-positive subjects were sensitized to three or more of the tested pollen allergens in the Western (52.1%), compared with 5.7% in the Eastern. Conclusion:There was an apparent geographic variation in childhood allergies in China. Age factors also had strong impacts on the allergen sensitization rate of children, but these impacts differed across regions.

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Section: Discussionmentioning

confidence: 99%

A Multicenter Study Assessing Risk Factors and Aeroallergens Sensitization Characteristics in Children with Self-Reported Allergic Rhinitis in China

Wu¹,

Luo²,

Hu³

et al. 2021

JAA

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“…The molecular analyses summarized in Table 3 provided further interesting insights. For example, in certain parts of southern China grass pollen sensitization seemed to be due to cross-reactive carbohydrates because most grass pollen sensitized patients mainly reacted with nPhl p 4 and nCyn d 1 whereas only few showed IgE reactivity to the clinically relevant grass pollen allergens such as Phl p 1, Phl p 5, Phl p 6, Phl p 12 (52,54). Additional studies have been performed in the western and northern parts of China, but results are not yet available.…”

Section: Information Regarding Molecular Sensitization Profiles In China Through First Studies Performed With Molecular Diagnosticsmentioning

confidence: 99%

The Molecular Allergen Recognition Profile in China as Basis for Allergen-Specific Immunotherapy

et al. 2021

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Approximately 30% of the world population suffers from immunoglobulin-E (IgE)-mediated allergy. IgE-mediated allergy affects the respiratory tract, the skin and the gastrointestinal tract and may lead to life-threatening acute systemic manifestations such as anaphylactic shock. The symptoms of allergy are mediated by IgE-recognition of causative allergen molecules from different allergen sources. Today, molecular allergy diagnosis allows determining the disease-causing allergens to develop allergen-specific concepts for prevention and treatment of allergy. Allergen-specific preventive and therapeutic strategies include allergen avoidance, vaccination, and tolerance induction. The implementation of these preventive and therapeutic strategies requires a detailed knowledge of the relevant allergen molecules affecting a given population. China is the world´s most populous country with around 1.4 billion inhabitants and an estimated number of more than 400 million allergic patients. Research in allergy in China has dramatically increased in the last decade. We summarize in this review article what is known about the dominating allergen sources and allergen molecules in China and what further investigations could be performed to draw a molecular map of IgE sensitization for China as a basis for the implementation of systematic and rational allergen-specific preventive and therapeutic strategies to combat allergic diseases in this country.

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“…It was shown that crossreactive carbohydrate determinants (CCDs) have a low influence on Phl p 12 sensitization. 28 In contrast, genuine allergy to timothy grass (positive results to Phl p 1, Phl p 5, and/or Phl p 6) was negatively correlated with weed or tree pollen sensitization.…”

Section: Dovepressmentioning

confidence: 92%

“…It has been demonstrated that Phl p 12 sIgE detection is positively correlated with Art v 4, a profilin allergen in mugwort pollen. 28 Thus, the high rate of sensitization to Phl p 12 was considered to result from cross-reactivity with weed/tree pollen (especially mugwort) allergy. It was shown that crossreactive carbohydrate determinants (CCDs) have a low influence on Phl p 12 sensitization.…”

Section: Dovepressmentioning

confidence: 99%

Sensitization Profiles of Timothy Grass Pollen in Northern China

Xu¹,

Guan²,

Sha³

et al. 2021

JAA

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Purpose: Grass pollen is an important cause of IgE-mediated allergy in countries worldwide, especially within Europe. However, there has been no research on grass pollen allergy in northern China. We aimed to determine the status of grass pollen allergy and the sensitization patterns to Phleum pratense (P. pratense) in northern China. Patients and Methods: Pollen data were collected for three geographic areas (Beijing, Shenmu, Shizuishan) in northern China. The study enrolled 101 patients (62 men; age range, 1-64 years; median age, 10 years) who had allergic rhinoconjunctivitis and/or asthma during the grass pollen season and positive skin prick test results positive to P. pratense. Serum-specific IgE (sIgE) against Phl p 1, Phl p 2, Phl p 5, Phl p 6, Phl p 7, Phl p 12 was measured by ImmunoCAP. Results: The pollen season of P. pratense was from June to September in Beijing, May to September in Shenmu and July to August in Shizuishan. P. pratense pollen accounted for 2-3% of the annual pollen index of total pollen counts. Among 101 patients with positive skin prick test results to P. pratense, 72% had detectable sIgE to P. pratense. Phl p 12 was the most frequently recognized component (45%), followed by Phl p 1 (22%), Phl p 5 (14%), Phl p 6 (8%) and Phl p 7 (3%). No patients had sIgE to Phl p 2. Ten sensitization patterns to the six components were observed. High rate of sIgE to Phl p 12 was positively correlated with co-sensitization to weed or tree pollen. Conclusion: Considering the pollen concentration, P. pratense was a minor pollen allergen in northern China and its pollen season overlapped with that of weed pollen. IgE sensitization to P. pratense was likely to be induced by cross-reactivity between grass pollen allergy and weed/tree pollen allergy.

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<p>Major Pollen Allergen Components and CCD Detection in Bermuda Grass Sensitized Patients in Guangzhou, China</p>

Cited by 16 publications

References 19 publications

A Multicenter Study Assessing Risk Factors and Aeroallergens Sensitization Characteristics in Children with Self-Reported Allergic Rhinitis in China

A Multicenter Study Assessing Risk Factors and Aeroallergens Sensitization Characteristics in Children with Self-Reported Allergic Rhinitis in China

The Molecular Allergen Recognition Profile in China as Basis for Allergen-Specific Immunotherapy

Sensitization Profiles of Timothy Grass Pollen in Northern China

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