Major Depressive Disorder in Taiwan Defined by the Chinese Diagnostic Interview Schedule

Chang, I-Hao; Yeh, Eng‐Kung; Chang, Ching‐Jui; Yeh, Ling‐Ling

doi:10.1097/00005053-199608000-00007

Cited by 46 publications

(34 citation statements)

References 17 publications

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“…The lower prevalence of MDD in Asians might partly be accounted for by underreporting due to cultural reluctance to endorse symptoms, by depressive symptoms being expressed as somatic symptoms, by greater resilience, by availability of more social support in Asian societies or by higher tolerance of symptoms and disease. 53,62,63,130 It is remarkable that the studies carried out in the eldest age groups appeared to have the highest ORs for the association of the BDNF Val66Met polymorphism with MDD ( Figures 2a and b: Hwang et al 42 and Taylor et al…”

Section: Discussionmentioning

confidence: 99%

“…Lower lifetime prevalence of MDD has been observed in Chinese, Japanese and Korean populations. 62,63 Cross-national epidemiologic surveys indicated that the lifetime prevalence of MDD is 1.5% in Taiwanese and 2.9% in Koreans, 53 compared to a mean of 15-17% in Western populations. 50,52,64 Although a number of the studies mentioned above have suggested the Met allele to be the risk allele for depression, the higher frequency of the Met allele in Asians in the presence of lower MDD prevalence rates might suggest that the Met allele protects against MDD.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

et al. 2008

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Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that has antidepressant-like effects in animals and may be implicated in the etiology of mood-related phenotypes. However, genetic association studies of the BDNF Val66Met polymorphism (single nucleotide polymorphism rs6265) in major depressive disorder (MDD) have produced inconsistent results. We conducted a meta-analysis of studies comparing the frequency of the BDNF Val66Met-coding variant in depressed cases (MDD) and nondepressed controls. A total of 14 studies involving 2812 cases with DSM-III or -IV defined MDD and 10 843 nondepressed controls met the inclusion criteria. Analyses were stratified either by gender or ethnicity (Asian and Caucasian) because MDD is more prevalent in women and in Caucasians and because BDNF allele frequencies differ by ethnicity. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were provided for allelic analyses (Met versus Val), as well as for genotypic analyses (Met/Met and Val/Met versus Val/Val). In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression. However, the gender stratified analyses revealed significant effects in both the allelic and genotypic analyses in men (OR MET , 95% CI; 1.27 (1.10-1.47); OR MET/MET , 95% CI; 1.67 (1.19-2.36)). Stratification according to ethnicity did not show significant effects of the Val66Met polymorphism on MDD. Our results suggest that the BDNF Val66Met polymorphism is of greater importance in the development of MDD in men than in women. Future research into gender issues will be of interest.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

et al. 2008

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“…Conversely, studies of East Asian samples indicated that the Val allele is associated with better cognitive function (Cheon et al 2008;Yeh et al 2009;Wang et al 2013). Considering the converse association findings of cognitive function mentioned above with COMT Val158Met in Caucasians and East Asians (Palmatier et al 1999) and the difference in the lifetime prevalence rate of MDD in Western vs. East Asian countries (Kessler et al 1994;Hwu et al 1996;Parker et al 2007), it is plausible to assume that the variant potentially involves MDD pathogenesis with ethnic differences, which may contribute to the inconsistency of previous findings.…”

Section: Introductionmentioning

confidence: 95%

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity

Wang

Yuan

et al. 2016

J Neuroimmune Pharmacol

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The COMT (catechol-O-methyltransferase) Val158Met polymorphism (rs4680) is a potential susceptibility variant for major depressive disorder (MDD). Although many genetic studies have examined the association between MDD and this polymorphism, the results were inconclusive. In the present study, we conducted a series of meta-analyses of samples consisting of 2905 MDD cases and 2403 controls with the goal of determining whether this variant indeed has any effect on MDD. We revealed a significant association in the comparison of Val/Val + Val/Met vs. Met/Met (OR =1.180; 95 % CI = 1.019, 1.367; P = 0.027), Val/Met vs. Val/Val (OR =1.18; 95 % CI = 1.038, 1.361; P = 0.013), and Val/Met vs. Met/Met (OR =1.229; 95 % CI = 1.053, 1.435; P = 0.009). Further meta-analyses of samples with European ancestry demonstrated a significant association of this SNP with MDD susceptibility in Val/Val + Val/Met vs. Met/Met (OR =1.231, 95 % CI = 1.046, 1.449; P = 0.013) and Val/Met vs. Met/Met (OR =1.284, 95 % CI = 1.050, 1.484; P = 0.012). For the samples with East Asian ancestry, we found a significant association in both allelic (Val vs. Met: OR =0.835; 95 % CI = 0.714, 0.975; P = 0.023) and genotypic (Met/Met + Val/Met vs. Val/Val: OR =1.431, 95 % CI = 1.143, 1.791; P = 0.002; Val/Met vs. Val/Val: OR =1.482, 95 % CI = 1.171, 1.871; P = 0.001) analyses. No evidence of heterogeneity among studies or publication bias was observed. Together, our results indicate that the COMT Val158Met polymorphism is a vulnerability factor for MDD with distinct effects in different ethnic populations.

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“…Depressive disorder is another well-known chronic, recurrent and disabling mental disease with high direct and indirect costs to society in both western and eastern cultures (Hwu et al, 1996;Cassano and Fava, 2002;Lu. et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-anxiety efficacy of Sudarshan Kriya Yoga in general anxiety disorder: A multicomponent, yoga based, breath intervention program for patients suffering from generalized anxiety disorder with or without comorbidities

Doria

Vuono²,

Sanlorenzo

et al. 2015

Journal of Affective Disorders

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Major Depressive Disorder in Taiwan Defined by the Chinese Diagnostic Interview Schedule

Cited by 46 publications

References 17 publications

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity

Anti-anxiety efficacy of Sudarshan Kriya Yoga in general anxiety disorder: A multicomponent, yoga based, breath intervention program for patients suffering from generalized anxiety disorder with or without comorbidities

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