Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two‐sample mendelian randomization analyses

Ren, Qian; Luo, Fangxiu; Song, Ge; Chen, Peizhan

doi:10.1002/cam4.5043

Cited by 15 publications

(13 citation statements)

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“…Depressive and anxiety disorders may share genetic diathesis [ 34 ]. A common genetic background has also been demonstrated between depression and some types of cancer [ 35 , 36 ]. A possible mediator of this common genetic background could be underlying personality traits (such as neuroticism and extraversion) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Cancer mortality in Common Mental Disorders: A 10-year retrospective cohort study

Chierzi¹,

Stivanello²,

Musti³

et al. 2022

Soc Psychiatry Psychiatr Epidemiol

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Purpose Individuals with Common Mental Disorders (CMDs) may have a higher cancer mortality. The purpose of this study was to examine cancer-related mortality among patients with CMDs and verify which cancer types are predominantly involved. Methods We used the Regional Mental Health Registry of the Emilia-Romagna region, in Northern Italy to identify patients aged ≥ 18 years who received an ICD 9-CM diagnosis of CMDs (i.e., depressive and neurotic disorders) over a 10 year period (2008–2017). Information on cause of death was retrieved from the Regional Cause of Death Registry. Comparisons were made with data from the regional population without CMDs. Results Among 101,487 patients suffering from CMDs (55.7% depression; 44.3% neurotic disorders), 3,087 (37.8%) died from neoplasms. The total standardized mortality ratio (SMR) was 1.82 (95% CI 1.78–1.86) while the SMR for all neoplasms was 2.08 (95% CI 2.01–2.16). Individuals of both genders, with both depressive and neurotic disorders had a higher risk of death from almost all cancers compared with the regional population. Conclusion Patients with CMDs have considerably higher cancer mortality risk than the general population. Higher mortality was observed for a broad range of cancers associated with different aetiologies. It is imperative to promote cancer awareness, prevention and treatment for people with CMDs.

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Section: Discussionmentioning

confidence: 99%

Cancer mortality in Common Mental Disorders: A 10-year retrospective cohort study

Chierzi¹,

Stivanello²,

Musti³

et al. 2022

Soc Psychiatry Psychiatr Epidemiol

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“…According to previous researches, MR analyses may result in false positives if genetic correlations occur among exposures (35,36). Consequently, two methods, multivariable IVW and multivariable MR-Egger, were employed to carry out multivariable MR analyses on 1 https://gwas.mrcieu.ac.uk/ major depressive disorder and schizophrenia.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Among the potential elements that may additionally influence risks of breast diseases, mental factors are receiving growing attention (3). Previous researches have linked some mental ailments to an multiplied hazard of breast cancer (4,5). Several observational studies confirmed that major depressive disorder would possibly increase the incidence of breast cancer (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

“…Mendelian inheritance holds that each parent randomly imparts one allele for each gene to its offspring ( 19 ). The MR analysis can overcome the risk of bias triggered by using unidentified confounding factors, reverse causality, and dimension errors ( 4 , 20 ). Therefore, The MR may serve as an alternative to randomized controlled trials ( 21 , 22 ).…”

Section: Introductionmentioning

confidence: 99%

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An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases: Mendelian randomization analyses

et al. 2023

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BackgroundPrevious observational studies have showed that certain psychiatric disorders may be linked to breast cancer risk, there is, however, little understanding of relationships between mental disorders and a variety of breast diseases. This study aims to investigate if mental disorders influence the risks of overall breast cancer, the two subtypes of breast cancer (ER+ and ER-), breast benign tumors and breast inflammatory diseases.MethodsDuring our research, genome-wide association study (GWAS) data for seven psychiatric disorders (schizophrenia, major depressive disorder, bipolar disorder, post-traumatic stress disorder, panic disorder, obsessive-compulsive disorder and anorexia nervosa) from the Psychiatric Genomics Consortium (PGC) and the UK Biobank were selected, and single-nucleotide polymorphisms (SNPs) significantly linked to these mental disorders were identified as instrumental variables. GWAS data for breast diseases came from the Breast Cancer Association Consortium (BCAC) as well as the FinnGen consortium. We performed two-sample Mendelian randomization (MR) analyses and multivariable MR analyses to assess these SNPs’ effects on various breast diseases. Both heterogeneity and pleiotropy were evaluated by sensitivity analyses.ResultsWhen the GWAS data of psychiatric disorders were derived from the PGC, our research found that schizophrenia significantly increased the risks of overall breast cancer (two-sample MR: OR 1.05, 95%CI [1.03-1.07], p = 3.84 × 10−6; multivariable MR: OR 1.06, 95%CI [1.04-1.09], p = 2.34 × 10−6), ER+ (OR 1.05, 95%CI [1.02-1.07], p = 5.94 × 10−5) and ER- (two-sample MR: OR 1.04, 95%CI [1.01-1.07], p = 0.006; multivariable MR: OR 1.06, 95%CI [1.02-1.10], p = 0.001) breast cancer. Nevertheless, major depressive disorder only showed significant positive association with overall breast cancer (OR 1.12, 95%CI [1.04-1.20], p = 0.003) according to the two-sample MR analysis, but not in the multivariable MR analysis. In regards to the remainder of the mental illnesses and breast diseases, there were no significant correlations. While as for the data from the UK Biobank, schizophrenia did not significantly increase the risk of breast cancer.ConclusionsThe correlation between schizophrenia and breast cancer found in this study may be false positive results caused by underlying horizontal pleiotropy, rather than a true cause-and-effect relationship. More prospective studies are still needed to be carried out to determine the definitive links between mental illnesses and breast diseases.

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“…Mental disorders constitute a major contributor to disease and economic burden globally, with depressive disorders accounting for the largest proportion of disability-adjusted life-years from mental disorders in 2019. 1 As a long-term psychological condition, a growing body of studies has demonstrated that depressive symptoms are associated with the risk of various physical conditions, such as diabetes, 2 dementia, 3 cancer 4 and cardiovascular disease (CVD), 5 as well as mortality. 6 For instance, a pooled analysis of 563 255 participants found that baseline depressive symptoms, as measured by the Center for Epidemiological Studies-Depression Scale or the Patient Health Questionnaire-2 (PHQ-2), were associated with a higher risk of CVD incidence.…”

Section: Introductionmentioning

confidence: 99%

Trajectories of depressive symptoms and risk of cardiovascular disease, cancer and mortality: a prospective cohort study

Min,

Cao,

Chen

et al. 2024

Gen Psych

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BackgroundDepressive symptoms are established risk factors for various health outcomes. However, previous studies assessed depressive symptoms at a single time point, neglecting individual variations over time.AimsTo identify depressive symptoms trajectories through repeated measures and examine their associations with cardiovascular disease (CVD), cancer and mortality.MethodsThis study included 20 634 UK Biobank participants free of CVD and cancer at baseline with two or more assessments of depressive symptoms during 2006–2016. Group-based trajectory modelling identified depressive symptoms trajectories. Incident CVD, cancer and mortality were followed up until 2021 through linked registries.ResultsSix depressive symptoms trajectories were identified: no symptoms (n=6407), mild-stable (n=11 539), moderate-stable (n=2183), severe-decreasing (n=206), moderate-increasing (n=177) and severe-stable (n=122). During a median follow-up of 5.5 years, 1471 CVD cases, 1275 cancer cases and 503 deaths were documented. Compared with the no symptoms trajectory, the mild-stable, moderate-stable and severe-stable trajectories exhibited higher CVD risk, with hazard ratios (HRs) (95% CIs) of 1.19 (1.06 to 1.34), 1.32 (1.08 to 1.34) and 2.99 (1.85 to 4.84), respectively. Moderate-increasing and severe-stable trajectories were associated with higher mortality risks, with HRs (95% CIs) of 2.27 (1.04 to 4.93) and 3.26 (1.55 to 6.88), respectively. However, the severe-decreasing trajectory was not associated with higher risks of adverse outcomes. We did not find significant associations between any trajectory and cancer.ConclusionsTrajectories related to stable and increasing depressive symptoms, but not the trajectory associated with severe depressive symptoms at the initial assessment but decreasing at the follow-up, were associated with higher risks of CVD and mortality. Alleviating severe depressive symptoms at the initial onset may mitigate CVD and mortality risks.

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Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two‐sample mendelian randomization analyses

Cited by 15 publications

References 62 publications

Cancer mortality in Common Mental Disorders: A 10-year retrospective cohort study

Cancer mortality in Common Mental Disorders: A 10-year retrospective cohort study

An exploration of the correlations between seven psychiatric disorders and the risks of breast cancer, breast benign tumors and breast inflammatory diseases: Mendelian randomization analyses

Trajectories of depressive symptoms and risk of cardiovascular disease, cancer and mortality: a prospective cohort study

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