Major depression, antidepressant use, and male and female fertility

Evans-Hoeker, Emily; Eisenberg, Esther; Diamond, Michael P.; Legro, Richard S.; Alvero, Ruben; Coutifaris, Christos; Casson, Peter R.; Christman, Gregory M.; Hansen, Karl R.; Zhang, Heping; Santoro, Nanette; Steiner, Anne Z.; Bartlebaugh, C.; Dodson, William C.; Estes, Stephanie J.; Gnatuk, Carol L.; Ladda, Roger L.; Ober, J.; Brzyski, Robert G.; Easton, C.; Hernández, Ana Teresa Echevarría; Leija, M.; Pierce, David W.; Robinson, Rick; Ager, Joel W.; Awonuga, Awoniyi O.; Cedó, Lídia; Cline, Allison; Collins, Kristina J.; Krawetz, S.; Puscheck, Elizabeth E.; Singh, Monika; Yoscovits, M.; Lecks, K.; Martino, Lucia De; Marunich, R.; Comfort, Alison B.; Crow, M.; Hohmann, Andrea G.; Mallette, Shirley; Smith, Yolanda R.; Randolph, John F.; Fisseha, Senait; Ohl, Dana A.; Ringbloom, M.; Tang, Julian; Bates, William M.; Mason, S E; Craig, LaTasha B.; Zornes, Christina; Rodriguez, Michael; Hunt, Travis; DiMaria, N.; Usadi, Rebecca; Lucidi, Scott; Rhea, M.; Baker, Vicki M.; Turner, Katherine; Brennan, Michael B.; DelBasso, D.; Huang, Hao; Jin, Y.; Li, Y.; Kuang, Hongying; Makuch, Robert W.; Patrizio, Pasquale; Sakai, Lynn Y.; Scahill, Lawrence David; Song, Chunhua; Taylor, Heather B.; Thomas, Tinku; Tsang, Steven Woon–Choy; Yan, Qingshang; Zhang, M.; Haisenleder, Daniel J.; Trussell, J. C.; Laylor, B.; Martinez, L.; Solnica, Amy; Wojtczuk, A.; Seungdamrong, Aimee; Rosen, M.P.; Lamar, Charisee A.; DePaolo, Louis V.; Guzick, David S.; Herring, Amy Mary Rose; Redmond, J. Bruce; Thomas, Melanie; Turek, Paul J.; Wactawski‐Wende, Jean; Rebar, Robert W.; Cato, Patrick; Dukić, Vanja; Lewis, Vivian; Schlegel, Peter N.; Witter, Frank R.

doi:10.1016/j.fertnstert.2018.01.029

Cited by 56 publications

(49 citation statements)

References 33 publications

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“…Another limitation of this study was the inability to distinguish whether the depressive and anxious symptoms experienced by the majority of study participants was due to postponing fertility treatment, due to pre-existing distress, or to distress caused by the pandemic itself. These levels of depression of anxiety and depression were higher than what has been previously published using the same measures in infertility patient populations suggesting that the delays to fertility treatment may have affected symptomatology [ 22 , 23 ]. Further, recent research finds infertility to frequently be more distressing that the COVID-19 pandemic [ 7 ] and to negatively affect fertility patient’s mental health [ 24 ].…”

Section: Discussionmentioning

confidence: 62%

Psychological distress and postponed fertility care during the COVID-19 pandemic

Lawson

McQueen

Swanson

et al. 2021

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 62%

Psychological distress and postponed fertility care during the COVID-19 pandemic

Lawson

McQueen

Swanson

et al. 2021

J Assist Reprod Genet

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“…In addition to decreased male fertility, psychiatric distress also diminishes sexual desire and causes erectile difficulties leading to sexual inactivity. The chances of conception in the female partners of psychologically stressed men were decreased as compared to the female partners of psychologically sound men [81]. Therefore, mental health becomes equally important as physical health to improve reproductive health in the current pandemic situations.…”

Section: Breastfeeding and Covid 19mentioning

confidence: 99%

SARS-CoV-2 and the reproductive system: known and the unknown..!!

Sharma

Kumari

Sharma

et al. 2021

Middle East Fertil Soc J

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Background COVID-19 is the most recent zoonotic outbreak of coronaviruses. Mostly, it invades the cells of the respiratory system by binding to the receptor angiotensin-converting enzyme 2 (ACE2) which is also present in other organs like the kidney, testis, ovaries, breast, heart, and intestine, rendering them prone to be infected. The reproductive potential is a must for the sustenance of any species and it is our prime duty to safeguard the reproductive system of the present generation from such a deadly virus. The previously reported coronaviruses like severe acute respiratory syndrome coronavirus (SARS-CoV) had a detrimental impact on reproductive organs. There is a dearth of sufficient research to provide substantial evidence for the harmful effects of this novel virus on the reproductive system. Hence, our review compiles the knowledge available until now to boost research in this regard and to take the necessary steps in time. Main body of abstract Here we tried to compile all the data available on the effect of SARS-CoV-2 on the reproductive system as well as vertical transmission of the virus. All related articles published from February to August 2020 were reviewed and thoroughly analyzed. SARS-CoV-2 has been found to affect the sperm concentration and motility, thus degrading the fertility of males. In females, it is suspected that this virus affects the oocyte quality and ovarian function, resulting in infertility or miscarriage. Traces of SARS-CoV-2 virus have also been found in the breast milk of the infected mothers and the semen of infected males. Vertical transmission of SARS-CoV-2 has also been reported in some cases. Conclusion Based on the literature review, SARS-CoV-2 seems to have the potential of affecting both male and female reproductive tracts. This review brings together the findings and observations made in the area of reproductive health during the current pandemic. The reproductive system of the young population is preordained for subsequent disorders, infertility, reduced sperm count, and motility. Therefore, the research and medical practices should focus on possible vulnerability being posed by SARS-CoV-2 to the gametes and future generations. We, hereby, recommend close monitoring of young and pregnant COVID-19 patients concerning reproductive health with utmost priority.

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“…In the male, physiological stress may lead to decreased sperm quality and enhanced sexual dysfunction [ 170 ]. This may be accompanied by inhibitory effects on the HPG axis, thereby affecting testosterone levels, which, in turn, may induce changes in Sertoli cells and the blood–testis barrier, leading to the arrest of spermatogenesis [ 171 ].…”

Section: Effects Of Sars-cov-2 and Other Viruses On Major Physiolomentioning

confidence: 99%

Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives

Roychoudhury

Das

Sengupta

et al. 2020

IJERPH

104

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The last four decades has witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein. The viral infections-mediated immunomodulation, and progressive inflammatory state may affect the functions of several other organs. Although no effective commercial vaccine is available for any of the viruses, those against SARS-CoV-2 are being developed at an unprecedented speed. Until now, only Pfizer/BioNTech’s vaccine has received temporary authorization from the UK Medicines and Healthcare products Regulatory Agency. Given the frequent emergence of viral pandemics in the 21st century, proper understanding of their characteristics and modes of action are essential to address the immediate and long-term health consequences.

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Major depression, antidepressant use, and male and female fertility

Abstract: NCT00719186 and NCT01044862.

Cited by 56 publications

References 33 publications

Psychological distress and postponed fertility care during the COVID-19 pandemic

Psychological distress and postponed fertility care during the COVID-19 pandemic

SARS-CoV-2 and the reproductive system: known and the unknown..!!

Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives

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